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Journal of Lipid Research, Vol. 4, 75-80, January 1963
Copyright © 1963 by Lipid Research, Inc.

Diet and cholesterolemia: VII. Effects of methionine, ethionine, and p-fluorophenylalanine

John C. Seidel and A. E. Harper

Department of Biochemistry, University of Wisconsin, Madison 6, Wisconsin

The concentration of serum cholesterol in rats fed a diet containing cholesterol, cholic acid, and hydrogenated coconut oil was reduced when ethionine was included in the diet. This effect was not due to depressed intake of food or of cholesterol. The addition of equal amounts of ethionine and methionine to this diet maintained serum cholesterol at levels significantly below those of rats supplemented with ethionine alone. This addition of methionine also very largely prevented the depression of growth caused by ethionine. Administration of p-fluorophenylalanine lowered the concentration of cholesterol in the serum but ßbeta;-2-thienylalanine had little effect.

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