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Journal of Lipid Research, Vol. 4, 96-99, January 1963
Copyright © 1963 by Lipid Research, Inc.

Breakdown of phospholipids in mild alkaline hydrolysis

Hans Brockerhoff

Fisheries Research Board of Canada, Technological Station, P.O. Box 429, Halifax, Nova Scotia, Canada

Deacylation of phospholipids by mild alkaline hydrolysis is usually accompanied by some hydrolysis of phosphate ester bonds. This undesired side reaction is suppressed by polar solvents. Deacylation with lithium hydroxide in chloroform-methanol 2:8 will cause the breakdown of not more than 0.1% of egg lecithin.

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