HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mohrhauer, H. Articles by Holman, R. T. Search for Related Content PubMed Articles by Mohrhauer, H. Articles by Holman, R. T. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 4, 151-159, April 1963
Copyright © 1963 by Lipid Research, Inc.

The effect of dose level of essential fatty acids upon fatty acid composition of the rat liver

Hans Mohrhauer and Ralph T. Holman

University of Minnesota, The Hormel Institute, Austin, Minnesota

Rats were fed various levels of either ethyl linoleate, ethyl arachidonate, or ethyl linolenate. Weight gain, fat-deficiency status, and fatty acid composition of the liver lipids were determined.

Dietary linoleate, fed in excess of 1% of calories, maintained good growth and cured fat deficiency. Increasing amounts of dietary linoleate were stored in the liver lipids and converted into fatty acids of the linoleate family—20:4 and 22:4. The concentration of 20:3 was decreased. Dietary arachidonate cured fat deficiency three times more effectively than linoleate. Increasing amounts of dietary arachidonate were stored in liver lipids and converted to 22:56. The level of 20:3 was lowered three times more effectively than when linoleate was fed. No fatty acids of the linolenate family were synthesized from linoleate or arachidonate.

Dietary linolenate did not support weight gain as efficiently as did linoleate or arachidonate. Fat-deficiency symptoms could not be cured completely. Increasing amounts of dietary linolenate increased the levels of fatty acids of the linolenate family; linolenic acid was stored, and 20:5, 22:53, and 22:6 were synthesized from linolenate. The level of 20:3 was lowered in the same fashion as when linoleate or arachidonate was fed. The level of 20:4 was decreased with increasing amounts of dietary linolenate.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				W. S. Harris, D. Mozaffarian, E. Rimm, P. Kris-Etherton, L. L. Rudel, L. J. Appel, M. M. Engler, M. B. Engler, and F. Sacks Omega-6 Fatty Acids and Risk for Cardiovascular Disease: A Science Advisory From the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention Circulation, February 17, 2009; 119(6): 902 - 907. [Full Text] [PDF]

				M. Wada, C. J. DeLong, Y. H. Hong, C. J. Rieke, I. Song, R. S. Sidhu, C. Yuan, M. Warnock, A. H. Schmaier, C. Yokoyama, et al. Enzymes and Receptors of Prostaglandin Pathways with Arachidonic Acid-derived Versus Eicosapentaenoic Acid-derived Substrates and Products J. Biol. Chem., August 3, 2007; 282(31): 22254 - 22266. [Abstract] [Full Text] [PDF]

				R. Portolesi, B. C. Powell, and R. A. Gibson Competition between 24:5n-3 and ALA for {Delta}6 desaturase may limit the accumulation of DHA in HepG2 cell membranes J. Lipid Res., July 1, 2007; 48(7): 1592 - 1598. [Abstract] [Full Text] [PDF]

				E. Sarkadi-Nagy, V. Wijendran, G. Y. Diau, A. C. Chao, A. T. Hsieh, A. Turpeinen, P. Lawrence, P. W. Nathanielsz, and J. T. Brenna Formula feeding potentiates docosahexaenoic and arachidonic acid biosynthesis in term and preterm baboon neonates J. Lipid Res., January 1, 2004; 45(1): 71 - 80. [Abstract] [Full Text] [PDF]

				E. M. Dahly, M. J. Grahn, A. K. Draxler, and D. M. Ney Intestinal Adaptation Occurs Independently of Parenteral Long-Chain Triacylglycerol and with No Change in Intestinal Eicosanoids after Mid-Small Bowel Resection in Rats J. Nutr., January 1, 2004; 134(1): 112 - 119. [Abstract] [Full Text] [PDF]

				J. Y. Lee, A. Plakidas, W. H. Lee, A. Heikkinen, P. Chanmugam, G. Bray, and D. H. Hwang Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids J. Lipid Res., March 1, 2003; 44(3): 479 - 486. [Abstract] [Full Text] [PDF]

				W.E.M. Lands Biochemistry and physiology of eicosanoid precursors in cell membranes Eur. Heart J. Suppl., June 1, 2001; 3(suppl_D): D22 - D25. [Abstract] [PDF]

				M. D. Boudreau, K. H. Sohn, S. H. Rhee, S. W. Lee, J. D. Hunt, and D. H. Hwang Suppression of Tumor Cell Growth Both in Nude Mice and in Culture by n-3 Polyunsaturated Fatty Acids: Mediation through Cyclooxygenase-independent Pathways Cancer Res., February 1, 2001; 61(4): 1386 - 1391. [Abstract] [Full Text]

				S. M Innis Essential fatty acids in infant nutrition: lessons and limitations from animal studies in relation to studies on infant fatty acid requirements Am. J. Clinical Nutrition, January 1, 2000; 71(1): 238S - 244S. [Abstract] [Full Text] [PDF]

				R. T. Holman The Slow Discovery of the Importance of omega 3 Essential Fatty Acids in Human Health J. Nutr., February 1, 1998; 128(2): 427 - 427. [Abstract] [Full Text]

				V. Tanphaichitr and N. Tangchurat Essential Fatty Acid Status in Adult Patients Receiving Soybean-base Formula JPEN J Parenter Enteral Nutr, March 1, 1981; 5(2): 106 - 109. [Abstract] [PDF]

				S. Bergstrom Prostaglandins: Members of a New Hormonal System: These physiologically very potent compounds of ubiquitous occurrence are formed from essential fatty acids Science, July 28, 1967; 157(3787): 382 - 391. [PDF]