Journal of Lipid Research, Vol. 4, 200-203, April 1963
Copyright © 1963 by Lipid Research, Inc.
Release of free fatty acids by adipose tissue from rats treated with triiodothyronine or propylthiouracil
Daniel Deykin and Martha Vaughan
Section on Metabolism, National Heart Institute, National Institutes of Health Bethesda 14, Maryland
Adipose tissue from rats treated with propylthiouracil released less free fatty acids (FFA) into the medium and contained less FFA at the end of a 1-hr incubation period than did tissue from euthyroid animals. The elevation of the concentration of tissue FFA and enhancement of FFA release induced in normal tissues by addition of epinephrine to the medium was not observed in tissues from animals treated with propylthiouracil. Tissues from rats treated with triiodothyronine released more FFA into the medium and contained more FFA after 1 hr of incubation than did control tissues. The tissues from rats treated with triiodothyronine, however, also contained more FFA before incubation than did control tissues and, as with control fat pads, there was no net accumulation of FFA during the incubation period. From measurement of total accumulation of glycerol during the same time, it was concluded that the rate of lipolysis in tissues from rats treated with triiodothyronine was increased above the control level. The rate of esterification of fatty acid (glyceride synthesis) was apparently also elevated. The effect of epinephrine on the release of FFA and glycerol was greater in tissues from triiodothyronine-treated rats than in the control tissues.
Submitted on September 6, 1962
Accepted on November 20, 1962
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