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Journal of Lipid Research, Vol. 4, 337-340, July 1963
Copyright © 1963 by Lipid Research, Inc.

Metabolism of coprostanol-C¹⁴ and cholestanol-4-C¹⁴ in man

R. S. Rosenfeld , Barnett Zumoff , and Leon Hellman

Division of Steroid Biochemistry and Metabolism, Sloan-Kettering Institute for Cancer Research; and Division of Neoplastic Medicine, Montefiore Hospital, New York, N.Y.

Coprostanol-C¹⁴, biosynthetically prepared, was administered orally to two patients, and cholestanol-4-C¹⁴ was administered to one of them 10 months later. At the time when radio-activity in the circulation was at a maximum, 3.6 and 3.5% of the administered labeled coprostanol was present in the plasma; the corresponding value after administration of cholestanol-C¹⁴ was 4.7%. The dynamic behavior of absorbed radioactive cholestanol was identical with that of orally ingested cholesterol-4-C¹⁴, including the esterification process; on the other hand, virtually no coprostanol ester was present in the circulation. It is suggested that the conformation of the A/B rings or configuration at C-3 are related to the esterification mechanism of sterols. After 5 days, over 50% of both compounds had been excreted in the feces. The conversion of coprostanol-C¹⁴ to coprostanone-C¹⁴ has been demonstrated.

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