|
 |
|
|||||||
|
|||||||||
Correspondence to:
Robert W. Mahley
The plasma clearance of intestinally derived remnant lipoproteins by the liver is a process that likely involves three steps. Our model suggests that the initial rapid clearance by the liver begins with sequestration of the remnants within the space of Disse, where apolipoprotein E secreted by hepatocytes enhances remnant binding and uptake. Heparan sulfate proteoglycans (HSPG), which are also abundant in the space of Disse, mediate this enhanced binding. Next, the remnants undergo further processing in the space of Disse by hepatic and lipoprotein lipases, which may also serve as ligands mediating remnant uptake. The final step, endocytosis by hepatocytes, appears to be mediated, at least in part, by the low density lipoprotein (LDL) receptor and by the LDL receptor-related protein (LRP). Cell-surface HSPG play a critical role in remnant uptake, not only in the important initial sequestration or capture step in the space of Disse, but also as an essential or integral component of the HSPG-LRP pathway. In addition, HSPG appear to function alone as a receptor and display unique handling properties for specific isoforms of apolipoprotein E.—Mahley, R. W., and Z-S. Ji. Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E. J. Lipid Res. 1999. 40: 1–16.
Supplementary key words:
remnants, apolipoprotein E, hepatic lipase, heparan sulfate proteoglycans, lipoprotein lipase
Copyright © 1999 by Lipid Research, Inc.
review
Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E
Robert W. Mahleya,b and
Zhong-Sheng Jia
a Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141-9100
a Cardiovascular Research Institute, University of California, San Francisco, CA 94141-9100
b Departments of Medicine and Pathology, University of California, San Francisco, CA 94141-9100
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Scarpellini, R. Germack, H. Lortat-Jacob, T. Muramatsu, E. Billett, T. Johnson, and E. A. M. Verderio Heparan Sulfate Proteoglycans Are Receptors for the Cell-surface Trafficking and Biological Activity of Transglutaminase-2 J. Biol. Chem., July 3, 2009; 284(27): 18411 - 18423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. K. Young, C. Chatterjee, and D. L. Sparks HDL-ApoE Content Regulates the Displacement of Hepatic Lipase from Cell Surface Proteoglycans Am. J. Pathol., July 1, 2009; 175(1): 448 - 457. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Getz and C. A. Reardon Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall J. Lipid Res., April 1, 2009; 50(Supplement): S156 - S161. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Kolovou, D. Damaskos, K. Anagnostopoulou, and D. V. Cokkinos Apolipoprotein E Gene Polymorphism and Gender Ann. Clin. Lab. Sci., January 1, 2009; 39(2): 120 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Tiffin, I. Okpechi, C. Perez-Iratxeta, M. A. Andrade-Navarro, and R. Ramesar Prioritization of candidate disease genes for metabolic syndrome by computational analysis of its defining phenotypes Physiol Genomics, September 17, 2008; 35(1): 55 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Hu, C. C. van der Hoogt, S. M. S. Espirito Santo, R. Out, K. E. Kypreos, B. J. M. van Vlijmen, T. J. C. Van Berkel, J. A. Romijn, L. M. Havekes, K. W. van Dijk, et al. The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI J. Lipid Res., July 1, 2008; 49(7): 1553 - 1561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. D. Burt, B. K. Agan, V. C. Marconi, W. He, H. Kulkarni, J. E. Mold, M. Cavrois, Y. Huang, R. W. Mahley, M. J. Dolan, et al. Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE {varepsilon}4/{varepsilon}4 genotype accelerates HIV disease progression PNAS, June 24, 2008; 105(25): 8718 - 8723. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. J. Goldberg, Y. Hu, H.-L. Noh, J. Wei, L. A. Huggins, M. G. Rackmill, H. Hamai, B. N. Reid, W. S. Blaner, and L.-S. Huang Decreased Lipoprotein Clearance Is Responsible for Increased Cholesterol in LDL Receptor Knockout Mice With Streptozotocin-Induced Diabetes Diabetes, June 1, 2008; 57(6): 1674 - 1682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gerritsen, C. C. van der Hoogt, F. G. Schaap, P. J. Voshol, K. E. Kypreos, N. Maeda, A. K. Groen, L. M. Havekes, P. C. N. Rensen, and K. W. van Dijk ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency J. Lipid Res., May 1, 2008; 49(5): 1048 - 1055. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Densupsoontorn, Y. A. Carpentier, R. Racine, F. M. Murray, T. Seo, R. Ramakrishnan, and R. J. Deckelbaum CD36 and Proteoglycan-Mediated Pathways for (n-3) Fatty Acid Enriched Triglyceride-Rich Particle Blood Clearance in Mouse Models In Vivo and in Peritoneal Macrophages In Vitro J. Nutr., February 1, 2008; 138(2): 257 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Van Eck, M. Hoekstra, R. Out, I. S. T. Bos, J. K. Kruijt, R. B. Hildebrand, and T. J. C. Van Berkel Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo J. Lipid Res., January 1, 2008; 49(1): 136 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Hofmann, D. Perez-Tilve, T. M. Greer, B. A. Coburn, E. Grant, J. E. Basford, M. H. Tschop, and D. Y. Hui Defective Lipid Delivery Modulates Glucose Tolerance and Metabolic Response to Diet in Apolipoprotein E Deficient Mice Diabetes, January 1, 2008; 57(1): 5 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Vila, N. Roglans, M. Alegret, A. Camins, M. Pallas, R. M. Sanchez, M. Vazquez-Carrera, and J. C. Laguna Hypertriglyceridemia and Hepatic Steatosis in Senescence-Accelerated Mouse Associate to Changes in Lipid-Related Gene Expression J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2007; 62(11): 1219 - 1227. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kockx, D. L. Guo, T. Huby, P. Lesnik, J. Kay, T. Sabaretnam, E. Jary, M. Hill, K. Gaus, J. Chapman, et al. Secretion of Apolipoprotein E From Macrophages Occurs via a Protein Kinase A and Calcium-Dependent Pathway Along the Microtubule Network Circ. Res., September 14, 2007; 101(6): 607 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pocathikorn, R. R. Taylor, I. James, and C. D. S. Mamotte LDL-Receptor mRNA Expression in Men Is Downregulated within an Hour of an Acute Fat Load and Is Influenced by Genetic Polymorphism J. Nutr., September 1, 2007; 137(9): 2062 - 2067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Kirkpatrick and S. B. Selleck Heparan sulfate proteoglycans at a glance J. Cell Sci., June 1, 2007; 120(11): 1829 - 1832. [Full Text] [PDF]
|
|
|
|
|
|
T. Tanaka, J. Delgado-Lista, J. Lopez-Miranda, F. Perez-Jimenez, C. Marin, P. Perez-Martinez, P. Gomez, and J. M. Ordovas Scavenger Receptor Class B Type I (SCARB1) c.1119C>T Polymorphism Affects Postprandial Triglyceride Metabolism in Men J. Nutr., March 1, 2007; 137(3): 578 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Cuellar, H. Chuong, S. M. Hubbell, and M. E. Hinsdale Biosynthesis of Chondroitin and Heparan Sulfate in Chinese Hamster Ovary Cells Depends on Xylosyltransferase II J. Biol. Chem., February 23, 2007; 282(8): 5195 - 5200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Liu, M. R. Hojjati, C. M. Devlin, I. H. Hansen, and X.-C. Jiang Macrophage Phospholipid Transfer Protein Deficiency and ApoE Secretion: Impact on Mouse Plasma Cholesterol Levels and Atherosclerosis Arterioscler. Thromb. Vasc. Biol., January 1, 2007; 27(1): 190 - 196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Azhar, S. Medicherla, W.-J. Shen, Y. Fujioka, L. G. Fong, E. Reaven, and A. D. Cooper LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells J. Lipid Res., November 1, 2006; 47(11): 2538 - 2550. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Spillmann, A. Lookene, and G. Olivecrona Isolation and Characterization of Low Sulfated Heparan Sulfate Sequences with Affinity for Lipoprotein Lipase J. Biol. Chem., August 18, 2006; 281(33): 23405 - 23413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-C. Chien, B. L. Yen, F.-K. Lee, T.-H. Lai, Y.-C. Chen, S.-H. Chan, and H.-I Huang In Vitro Differentiation of Human Placenta-Derived Multipotent Cells into Hepatocyte-Like Cells Stem Cells, July 1, 2006; 24(7): 1759 - 1768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Westerterp, W. de Haan, J. F. P. Berbee, L. M. Havekes, and P. C. N. Rensen Endogenous apoC-I increases hyperlipidemia in apoE-knockout mice by stimulating VLDL production and inhibiting LPL J. Lipid Res., June 1, 2006; 47(6): 1203 - 1211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Page, A. Judson, K. Melford, and A. Bensadoun Interaction of Lipoprotein Lipase and Receptor-associated Protein J. Biol. Chem., May 19, 2006; 281(20): 13931 - 13938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Xu, A. Bernardo, D. Walker, T. Kanegawa, R. W. Mahley, and Y. Huang Profile and Regulation of Apolipoprotein E (ApoE) Expression in the CNS in Mice with Targeting of Green Fluorescent Protein Gene to the ApoE Locus. J. Neurosci., May 10, 2006; 26(19): 4985 - 4994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Heeren, U. Beisiegel, and T. Grewal Apolipoprotein E Recycling: Implications for Dyslipidemia and Atherosclerosis Arterioscler. Thromb. Vasc. Biol., March 1, 2006; 26(3): 442 - 448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z.-S. Ji, K. Mullendorff, I. H. Cheng, R. D. Miranda, Y. Huang, and R. W. Mahley Reactivity of Apolipoprotein E4 and Amyloid beta Peptide: LYSOSOMAL STABILITY AND NEURODEGENERATION J. Biol. Chem., February 3, 2006; 281(5): 2683 - 2692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. G. Jackson, V. Maitin, D. S. Leake, P. Yaqoob, and C. M. Williams Saturated fat-induced changes in Sf 60-400 particle composition reduces uptake of LDL by HepG2 cells J. Lipid Res., February 1, 2006; 47(2): 393 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Getz and C. A. Reardon Diet and Murine Atherosclerosis Arterioscler. Thromb. Vasc. Biol., February 1, 2006; 26(2): 242 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Llorente-Cortes, M. Otero-Vinas, S. Camino-Lopez, P. Costales, and L. Badimon Cholesteryl Esters of Aggregated LDL Are Internalized by Selective Uptake in Human Vascular Smooth Muscle Cells Arterioscler. Thromb. Vasc. Biol., January 1, 2006; 26(1): 117 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. Cain, J. S. Millar, A. S. Himebauch, U. J. F. Tietge, C. Maugeais, D. Usher, and D. J. Rader Lipoprotein [a] is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein [a] J. Lipid Res., December 1, 2005; 46(12): 2681 - 2691. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. S. Descamps, M. Bruniaux, P.-F. Guilmot, R. Tonglet, and F. R. Heller Lipoprotein metabolism of pregnant women is associated with both their genetic polymorphisms and those of their newborn children J. Lipid Res., November 1, 2005; 46(11): 2405 - 2414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sakurai, S.-y. Morita, K. Wakita, Y. Deharu, M. Nakano, and T. Handa Effects of cholesterol in chylomicron remnant models of lipid emulsions on apoE-mediated uptake and cytotoxicity of macrophages J. Lipid Res., October 1, 2005; 46(10): 2214 - 2220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Bach-Ngohou, K. Ouguerram, R. Frenais, P. Maugere, B. Ripolles-Piquer, Y. Zair, M. Krempf, and J. M. Bard Influence of Atorvastatin on Apolipoprotein E and AI Kinetics in Patients with Type 2 Diabetes J. Pharmacol. Exp. Ther., October 1, 2005; 315(1): 363 - 369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Camejo Differential Antiatherogenic Effects of PPAR{alpha} Versus PPAR{gamma} Agonists: Should We Be Surprised? Arterioscler. Thromb. Vasc. Biol., September 1, 2005; 25(9): 1763 - 1764. [Full Text] [PDF]
|
|
|
|
|
|
C. M. Devlin, S.-J. Lee, G. Kuriakose, C. Spencer, L. Becker, I. Grosskopf, C. Ko, L.-S. Huang, M. L. Koschinsky, A. D. Cooper, et al. An Apolipoprotein(a) Peptide Delays Chylomicron Remnant Clearance and Increases Plasma Remnant Lipoproteins and Atherosclerosis In Vivo Arterioscler. Thromb. Vasc. Biol., August 1, 2005; 25(8): 1704 - 1710. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Carpenter, Y. Lin, S. Stoll, R. L. Raffai, R. McCuskey, and R. Wang VEGF is crucial for the hepatic vascular development required for lipoprotein uptake Development, July 15, 2005; 132(14): 3293 - 3303. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lookene, J. A. Beckstead, S. Nilsson, G. Olivecrona, and R. O. Ryan Apolipoprotein A-V-heparin Interactions: IMPLICATIONS FOR PLASMA LIPOPROTEIN METABOLISM J. Biol. Chem., July 8, 2005; 280(27): 25383 - 25387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Hasty, M. R. Plummer, K. H. Weisgraber, M. F. Linton, S. Fazio, and L. L. Swift The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I J. Lipid Res., July 1, 2005; 46(7): 1433 - 1439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Gupta, C. R. White, S. Handattu, D. W. Garber, G. Datta, M. Chaddha, L. Dai, S. H. Gianturco, W. A. Bradley, and G.M. Anantharamaiah Apolipoprotein E Mimetic Peptide Dramatically Lowers Plasma Cholesterol and Restores Endothelial Function in Watanabe Heritable Hyperlipidemic Rabbits Circulation, June 14, 2005; 111(23): 3112 - 3118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Out, M. Hoekstra, S. C. A. de Jager, P. de Vos, D. R. van der Westhuyzen, N. R. Webb, M. Van Eck, E. A. L. Biessen, and T. J. C. Van Berkel Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice J. Lipid Res., June 1, 2005; 46(6): 1172 - 1181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F.P. Berbee, L. M. Havekes, and P. C.N. Rensen Apolipoproteins modulate the inflammatory response to lipopolysaccharide Innate Immunity, April 1, 2005; 11(2): 97 - 103. [Abstract] [PDF]
|
|
|
|
|
|
K. J. Williams, M.-L. Liu, Y. Zhu, X. Xu, W. R. Davidson, P. McCue, and K. Sharma Loss of Heparan N-Sulfotransferase in Diabetic Liver: Role of Angiotensin II Diabetes, April 1, 2005; 54(4): 1116 - 1122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Futamura, P. Dhanasekaran, T. Handa, M. C. Phillips, S. Lund-Katz, and H. Saito Two-step Mechanism of Binding of Apolipoprotein E to Heparin: IMPLICATIONS FOR THE KINETICS OF APOLIPOPROTEIN E-HEPARAN SULFATE PROTEOGLYCAN COMPLEX FORMATION ON CELL SURFACES J. Biol. Chem., February 18, 2005; 280(7): 5414 - 5422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Aoki, D. Sato, Y. Li, T. Takino, H. Miyamori, and H. Sato Cleavage of Apolipoprotein E by Membrane-Type Matrix Metalloproteinase-1 Abrogates Suppression of Cell Proliferation J. Biochem., January 1, 2005; 137(1): 95 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Barter The realities of dyslipidaemia in metabolic syndrome and diabetes The British Journal of Diabetes & Vascular Disease, January 1, 2005; 5(1_suppl): S7 - S11. [Abstract] [PDF]
|
|
|
|
|
|
J. Heeren, T. Grewal, A. Laatsch, N. Becker, F. Rinninger, K.-A. Rye, and U. Beisiegel Impaired Recycling of Apolipoprotein E4 Is Associated with Intracellular Cholesterol Accumulation J. Biol. Chem., December 31, 2004; 279(53): 55483 - 55492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-J. Lee, I. Grosskopf, S. Y. Choi, and A. D. Cooper Chylomicron remnant uptake in the livers of mice expressing human apolipoproteins E3, E2 (Arg158->Cys), and E3-Leiden J. Lipid Res., December 1, 2004; 45(12): 2199 - 2210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-F. Landrier, C. Thomas, J. Grober, H. Duez, F. Percevault, M. Souidi, C. Linard, B. Staels, and P. Besnard Statin Induction of Liver Fatty Acid-Binding Protein (L-FABP) Gene Expression Is Peroxisome Proliferator-activated Receptor-{alpha}-dependent J. Biol. Chem., October 29, 2004; 279(44): 45512 - 45518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Argov, U. Moallem, and D. Sklan Lipid Transport in the Developing Bovine Follicle: Messenger RNA Expression Increases for Selective Uptake Receptors and Decreases for Endocytosis Receptors Biol Reprod, August 1, 2004; 71(2): 479 - 485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-y. Morita, M. Kawabe, A. Sakurai, K. Okuhira, A. Vertut-Doi, M. Nakano, and T. Handa Ceramide in Lipid Particles Enhances Heparan Sulfate Proteoglycan and Low Density Lipoprotein Receptor-related Protein-mediated Uptake by Macrophages J. Biol. Chem., June 4, 2004; 279(23): 24355 - 24361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Oestvang, D. Bonnefont-Rousselot, E. Ninio, J. K. Hakala, B. Johansen, and M. W. Anthonsen Modification of LDL with human secretory phospholipase A2 or sphingomyelinase promotes its arachidonic acid-releasing propensity J. Lipid Res., May 1, 2004; 45(5): 831 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Out, J. K. Kruijt, P. C. N. Rensen, R. B. Hildebrand, P. de Vos, M. Van Eck, and T. J. C. Van Berkel Scavenger Receptor BI Plays a Role in Facilitating Chylomicron Metabolism J. Biol. Chem., April 30, 2004; 279(18): 18401 - 18406. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Dichek, K. Qian, and N. Agrawal The bridging function of hepatic lipase clears plasma cholesterol in LDL receptor-deficient "apoB-48-only" and "apoB-100-only" mice J. Lipid Res., March 1, 2004; 45(3): 551 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. I. Malloy, M. K. Altenburg, C. Knouff, L. Lanningham-Foster, J. S. Parks, and N. Maeda Harmful Effects of Increased LDLR Expression in Mice With Human APOE*4 But Not APOE*3 Arterioscler. Thromb. Vasc. Biol., January 1, 2004; 24(1): 91 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Trovati and F. Cavalot Optimization of Hypolipidemic and Antiplatelet Treatment in the Diabetic Patient with Renal Disease J. Am. Soc. Nephrol., January 1, 2004; 15(90010): S12 - 20. [Abstract] [Full Text]
|
|
|
|
 |
|
 H. Masuno, S. Okamoto, J. Iwanami, K. Honda, T. Shiosaka, T. Kidani, K. Sakayama, and H. Yamamoto Effect of 4-Nonylphenol on Cell Proliferation and Adipocyte Formation in Cultures of Fully Differentiated 3T3-L1 Cells Toxicol. Sci., October 1, 2003; 75(2): 314 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Van Amersfoort, T. J. C. Van Berkel, and J. Kuiper Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock Clin. Microbiol. Rev., July 1, 2003; 16(3): 379 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Kiss, P. M. M. Weers, V. Narayanaswami, J. Cohen, C. M. Kay, and R. O. Ryan Structure-guided Protein Engineering Modulates Helix Bundle Exchangeable Apolipoprotein Properties J. Biol. Chem., June 6, 2003; 278(24): 21952 - 21959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Anisfeld, H. R. Kast-Woelbern, M. E. Meyer, S. A. Jones, Y. Zhang, K. J. Williams, T. Willson, and P. A. Edwards Syndecan-1 Expression Is Regulated in an Isoform-specific Manner by the Farnesoid-X Receptor J. Biol. Chem., May 23, 2003; 278(22): 20420 - 20428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Wilsie and R. A. Orlando The Low Density Lipoprotein Receptor-related Protein Complexes with Cell Surface Heparan Sulfate Proteoglycans to Regulate Proteoglycan-mediated Lipoprotein Catabolism J. Biol. Chem., April 25, 2003; 278(18): 15758 - 15764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Saito, P. Dhanasekaran, D. Nguyen, F. Baldwin, K. H. Weisgraber, S. Wehrli, M. C. Phillips, and S. Lund-Katz Characterization of the Heparin Binding Sites in Human Apolipoprotein E J. Biol. Chem., April 18, 2003; 278(17): 14782 - 14787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Heeren, T. Grewal, A. Laatsch, D. Rottke, F. Rinninger, C. Enrich, and U. Beisiegel Recycling of Apoprotein E Is Associated with Cholesterol Efflux and High Density Lipoprotein Internalization J. Biol. Chem., April 11, 2003; 278(16): 14370 - 14378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hidaka, M. Tozuka, B. Meyer, K. Yamauchi, M. Sugano, T. Nakabayashi, and T. Katsuyama Characterization of Triglyceride Rich Lipoproteins with Very Light Density by Ultracentrifugation and Agarose Gel Electrophoresis using Triglyceride- and Cholesterol-Staining Ann. Clin. Lab. Sci., April 1, 2003; 33(2): 167 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Raffai, A. H. Hasty, Y. Wang, S. E. Mettler, D. A. Sanan, M. F. Linton, S. Fazio, and K. H. Weisgraber Hepatocyte-derived ApoE Is More Effective than Non-hepatocyte-derived ApoE in Remnant Lipoprotein Clearance J. Biol. Chem., March 21, 2003; 278(13): 11670 - 11675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Paradis, S. Clement, P. Julien, and M. R. Ven Murthy Lipoprotein Lipase Affects the Survival and Differentiation of Neural Cells Exposed to Very Low Density Lipoprotein J. Biol. Chem., March 7, 2003; 278(11): 9698 - 9705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Temel, J. S. Parks, and D. L. Williams Enhancement of Scavenger Receptor Class B Type I-mediated Selective Cholesteryl Ester Uptake from apoA-I-/- High Density Lipoprotein (HDL) by Apolipoprotein A-I Requires HDL Reorganization by Lecithin Cholesterol Acyltransferase J. Biol. Chem., February 7, 2003; 278(7): 4792 - 4799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Gerritsen, K. E. Kypreos, A. van der Zee, B. Teusink, V. I. Zannis, L. M. Havekes, and K. W. van Dijk Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain J. Lipid Res., February 1, 2003; 44(2): 408 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yamauchi, M. Tozuka, E. Hidaka, I. Ueno, K. Matsuda, and T. Katsuyama Internalization of {beta}-Amyloid Causes Downregulation of Apolipoprotein E mRNA Expression in Neuroblastoma Cells Ann. Clin. Lab. Sci., January 1, 2003; 33(1): 68 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. von Bergmann, D. Lutjohann, B. Lindenthal, and A. Steinmetz Efficiency of intestinal cholesterol absorption in humans is not related to apoE phenotype J. Lipid Res., January 1, 2003; 44(1): 193 - 197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Blom, P. Byrnes, S. Jones, and A. D. Marais Non-denaturing polyacrylamide gradient gel electrophoresis for the diagnosis of dysbetalipoproteinemia J. Lipid Res., January 1, 2003; 44(1): 212 - 217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Y. Hui and P. N. Howles Carboxyl ester lipase: structure-function relationship and physiological role in lipoprotein metabolism and atherosclerosis J. Lipid Res., December 1, 2002; 43(12): 2017 - 2030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Mullick, R. J. Deckelbaum, I. J. Goldberg, M. Al-Haideri, and J. C. Rutledge Apolipoprotein E and Lipoprotein Lipase Increase Triglyceride-Rich Particle Binding but Decrease Particle Penetration in Arterial Wall Arterioscler. Thromb. Vasc. Biol., December 1, 2002; 22(12): 2080 - 2085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. R. Hopkins, Y. Huang, J. G. McGuire, and R. E. Pitas Evidence for differential effects of apoE3 and apoE4 on HDL metabolism J. Lipid Res., November 1, 2002; 43(11): 1881 - 1889. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. E. Thorngate, P. A. Strockbine, S. K. Erickson, and D. L. Williams Altered adrenal gland cholesterol metabolism in the apoE-deficient mouse J. Lipid Res., November 1, 2002; 43(11): 1920 - 1926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Olin-Lewis, R. M. Krauss, M. La Belle, P. J. Blanche, P. H. R. Barrett, T. N. Wight, and A. Chait ApoC-III content of apoB-containing lipoproteins is associated with binding to the vascular proteoglycan biglycan J. Lipid Res., November 1, 2002; 43(11): 1969 - 1977. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. N. Ginsberg New Perspectives on Atherogenesis: Role of Abnormal Triglyceride-Rich Lipoprotein Metabolism Circulation, October 15, 2002; 106(16): 2137 - 2142. [Full Text] [PDF]
|
|
|
|
|
|
S. Sandgren, F. Cheng, and M. Belting Nuclear Targeting of Macromolecular Polyanions by an HIV-Tat Derived Peptide. ROLE FOR CELL-SURFACE PROTEOGLYCANS J. Biol. Chem., October 4, 2002; 277(41): 38877 - 38883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Guerin, P. Egger, C. Soudant, W. Le Goff, A. van Tol, R. Dupuis, and M. J. Chapman Cholesteryl ester flux from HDL to VLDL-1 is preferentially enhanced in type IIB hyperlipidemia in the postprandial state J. Lipid Res., October 1, 2002; 43(10): 1652 - 1660. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bultel-Brienne, S. Lestavel, A. Pilon, I. Laffont, A. Tailleux, J.-C. Fruchart, G. Siest, and V. Clavey Lipid Free Apolipoprotein E Binds to the Class B Type I Scavenger Receptor I (SR-BI) and Enhances Cholesteryl Ester Uptake from Lipoproteins J. Biol. Chem., September 20, 2002; 277(39): 36092 - 36099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Vasandani, A. I. Kafrouni, A. Caronna, Y. Bashmakov, M. Gotthardt, J. D. Horton, and D. K. Spady Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice J. Lipid Res., May 1, 2002; 43(5): 772 - 784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Chan, G. F. Watts, P. H. R. Barrett, T. A. Mori, L. J. Beilin, and T. G. Redgrave Mechanism of Action of a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor on Apolipoprotein B-100 Kinetics in Visceral Obesity J. Clin. Endocrinol. Metab., May 1, 2002; 87(5): 2283 - 2289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E.S. Tai, S. Demissie, L.A. Cupples, D. Corella, P.W. Wilson, E.J. Schaefer, and J.M. Ordovas Association Between the PPARA L162V Polymorphism and Plasma Lipid Levels: The Framingham Offspring Study Arterioscler. Thromb. Vasc. Biol., May 1, 2002; 22(5): 805 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Levinson High Density- and Beta-Lipoprotein Screening for Risk of Coronary Artery Disease in the Context of New Findings on Reverse Cholesterol Transport Ann. Clin. Lab. Sci., April 1, 2002; 32(2): 123 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Raffai and K. H. Weisgraber Hypomorphic Apolipoprotein E Mice. A NEW MODEL OF CONDITIONAL GENE REPAIR TO EXAMINE APOLIPOPROTEIN E-MEDIATED METABOLISM J. Biol. Chem., March 22, 2002; 277(13): 11064 - 11068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Forte, G. Subbanagounder, J. A. Berliner, P. J. Blanche, A. O. Clermont, Z. Jia, M. N. Oda, R. M. Krauss, and J. K. Bielicki Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice J. Lipid Res., March 1, 2002; 43(3): 477 - 485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Harris, I. R. Graham, S. Schepelmann, A. K. Stannard, M. L. Roberts, B. L. Hodges, V. Hill, A. Amalfitano, D. G. Hassall, J. S. Owen, et al. Acute regression of advanced and retardation of early aortic atheroma in immunocompetent apolipoprotein-E (apoE) deficient mice by administration of a second generation [E1-, E3-, polymerase-] adenovirus vector expressing human apoE Hum. Mol. Genet., January 1, 2002; 11(1): 43 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H. MOGHADASIAN, B. M. McMANUS, L. B. NGUYEN, S. SHEFER, M. NADJI, D. V. GODIN, T. J. GREEN, J. HILL, Y. YANG, C. H. SCUDAMORE, et al. Pathophysiology of apolipoprotein E deficiency in mice: relevance to apo E-related disorders in humans FASEB J, December 1, 2001; 15(14): 2623 - 2630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Stein, S. Devaraj, D. Balis, B. Adams-Huet, and I. Jialal Effect of Statin Therapy on Remnant Lipoprotein Cholesterol Levels in Patients With Combined Hyperlipidemia Arterioscler. Thromb. Vasc. Biol., December 1, 2001; 21(12): 2026 - 2031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Heeren, T. Grewal, S. Jackle, and U. Beisiegel Recycling of Apolipoprotein E and Lipoprotein Lipase through Endosomal Compartments in Vivo J. Biol. Chem., November 2, 2001; 276(45): 42333 - 42338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Fan, H. Unoki, N. Kojima, H. Sun, H. Shimoyamada, H. Deng, M. Okazaki, H. Shikama, N. Yamada, and T. Watanabe Overexpression of Lipoprotein Lipase in Transgenic Rabbits Inhibits Diet-induced Hypercholesterolemia and Atherosclerosis J. Biol. Chem., October 19, 2001; 276(43): 40071 - 40079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Libeu, S. Lund-Katz, M. C. Phillips, S. Wehrli, M. J. Hernaiz, I. Capila, R. J. Linhardt, R. L. Raffai, Y. M. Newhouse, F. Zhou, et al. New Insights into the Heparan Sulfate Proteoglycan-binding Activity of Apolipoprotein E J. Biol. Chem., October 12, 2001; 276(42): 39138 - 39144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hirano, T. Takahashi, S. Saito, H. Tajima, T. Ebara, and M. Adachi Apoprotein C-III deficiency markedly stimulates triglyceride secretion in vivo: comparison with apoprotein E Am J Physiol Endocrinol Metab, October 1, 2001; 281(4): E665 - E669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Burgess and Y. L. Marcel Dynamic and stable pools of apoE differ functionally at the HepG2 cell surface J. Lipid Res., September 1, 2001; 42(9): 1413 - 1420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Olsson, A.-C. Egnell, M. R. Lee, G. O. Lunden, M. Lorentzon, M. Salmivirta, G. Bondjers, and G. Camejo Changes in Matrix Proteoglycans Induced by Insulin and Fatty Acids in Hepatic Cells May Contribute to Dyslipidemia of Insulin Resistance Diabetes, September 1, 2001; 50(9): 2126 - 2132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Lund-Katz, S. Wehrli, M. Zaiou, Y. Newhouse, K. H. Weisgraber, and M. C. Phillips Effects of polymorphism on the microenvironment of the LDL receptor-binding region of human apoE J. Lipid Res., June 1, 2001; 42(6): 894 - 901. [Abstract] [Full Text]
|
|
|
|
|
|
M.-a. Kawashiri, Y. Zhang, D. Usher, M. Reilly, E. Puré, and D. J. Rader Effects of coexpression of the LDL receptor and apoE on cholesterol metabolism and atherosclerosis in LDL receptor-deficient mice J. Lipid Res., June 1, 2001; 42(6): 943 - 950. [Abstract] [Full Text]
|
|
|
|
|
|
G. Datta, D. W. Garber, B. H. Chung, M. Chaddha, N. Dashti, W. A. Bradley, S. H. Gianturco, and G. M. Anantharamaiah Cationic domain 141-150 of apoE covalently linked to a class A amphipathic helix enhances atherogenic lipoprotein metabolism in vitro and in vivo J. Lipid Res., June 1, 2001; 42(6): 959 - 966. [Abstract] [Full Text]
|
|
|
|
|
|
H. Relas, H. Gylling, and T. A. Miettinen Fate of intravenously administered squalene and plant sterols in human subjects J. Lipid Res., June 1, 2001; 42(6): 988 - 994. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. J. Bame Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans Glycobiology, June 1, 2001; 11(6): 91R - 98R. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |