HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schmidt, D. E. Articles by Kien, C. L. Search for Related Content PubMed PubMed Citation Articles by Schmidt, D. E. Articles by Kien, C. L. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 40, 2322-2332, December 1999
Copyright © 1999 by Lipid Research, Inc.

Original Article

Fractional oxidation of chylomicron-derived oleate is greater than that of palmitate in healthy adults fed frequent small meals

Correspondence to: C. Lawrence Kien

Differences in oxidation of individual dietary fatty acids could contribute to the effect of dietary fat composition on risk factors for non-insulin-dependent diabetes mellitus and cardiovascular disease. Using a novel stable isotope technique, we compared fractional oxidation of chylomicron-derived oleate and palmitate in 10 healthy adults in a crossover study. 1-¹³C-labeled oleate or palmitate was emulsified into a eucaloric formula diet administered each 20 min for 7 h to produce a plateau in excretion of ¹³C label in breath CO₂. Unlabeled oleate and palmitate each provided 16% of dietary energy, and other fatty acids provided 8% of energy. Total dietary fat was 40% of energy, carbohydrate was 46%, and protein was 14%. Diet without tracer was fed for 2 h before beginning tracer administration to establish a baseline fed state. Relative oxidation of oleate versus palmitate was defined as fractional oxidation of oleate divided by fractional oxidation of palmitate. Relative oxidation averaged 1.21 (99.5% confidence interval = 1.03;–1.39), indicating that fractional oxidation of oleate was significantly greater than that of palmitate.—Schmidt, D. E., J. B. Allred, and C. L. Kien. Fractional oxidation of chylomicron-derived oleate is greater than that of palmitate in healthy adults fed frequent small meals. J. Lipid Res. 1999. 40: 2322;–2332.

Supplementary key words: dietary fat, chylomicrons, fatty acid oxidation, stable isotopes

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				R. B. Heath, F. Karpe, R. W. Milne, G. C. Burdge, S. A. Wootton, and K. N. Frayn Dietary fatty acids make a rapid and substantial contribution to VLDL-triacylglycerol in the fed state Am J Physiol Endocrinol Metab, March 1, 2007; 292(3): E732 - E739. [Abstract] [Full Text] [PDF]

				A. Vedala, W. Wang, R. A. Neese, M. P. Christiansen, and M. K. Hellerstein Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans J. Lipid Res., November 1, 2006; 47(11): 2562 - 2574. [Abstract] [Full Text] [PDF]

				C L. Kien, J. Y Bunn, and F. Ugrasbul Increasing dietary palmitic acid decreases fat oxidation and daily energy expenditure Am. J. Clinical Nutrition, August 1, 2005; 82(2): 320 - 326. [Abstract] [Full Text] [PDF]

				C L. Kien and F. Ugrasbul Prediction of daily energy expenditure during a feeding trial using measurements of resting energy expenditure, fat-free mass, or Harris-Benedict equations Am. J. Clinical Nutrition, October 1, 2004; 80(4): 876 - 880. [Abstract] [Full Text] [PDF]

				M. Rodriguez, S. Funke, M. Fink, H. Demmelmair, M. Turini, G. Crozier, and B. Koletzko Plasma fatty acids and [13C]linoleic acid metabolism in preterm infants fed a formula with medium-chain triglycerides J. Lipid Res., January 1, 2003; 44(1): 41 - 48. [Abstract] [Full Text] [PDF]

				K. A. Hatch, B. Pinshow, and J. R. Speakman The Analysis of 13C/12C Ratios in Exhaled CO2: Its Advantages and Potential Application to Field Research to Infer Diet, Changes in Diet Over Time, and Substrate Metabolism in Birds Integr. Comp. Biol., February 1, 2002; 42(1): 21 - 33. [Abstract] [Full Text] [PDF]