| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Correspondence to:
Carl Grunfeld
Regulation of lipid metabolism during infection is thought to be part of host defense, as lipoproteins neutralize endotoxin (LPS) and viruses. Gram-positive infections also induce disturbances in lipid metabolism. Therefore, we investigated whether lipoproteins could inhibit the toxic effects of lipoteichoic acid (LTA), a fragment of gram-positive bacteria. LTA activated RAW264.7 macrophage cells, stimulating production of tumor necrosis factor (TNF) in a dose-dependent matter, but produced less TNF than that seen after LPS activation. High density (HDL) or low density lipoprotein (LDL) alone inhibited the ability of LPS to stimulate TNF production, but had little effect on the activation by LTA. When a maximally effective dose of LTA was mixed with lipoproteins and 10% lipoprotein-depleted plasma (LPDP), the ability of LTA to stimulate macrophage production of TNF was inhibited. HDL, LDL, and the synthetic particle, Soyacal, when mixed with LPDP, were able to inhibit the ability of LTA to activate macrophages. Lipopolysaccharide-binding protein (LBP) substituted for LPDP in catalyzing lipoprotein neutralization of LTA by HDL. Antibody to LBP inhibited the ability of LPDP to induce LTA neutralization by HDL.
Thus, lipoproteins can prevent macrophage activation by fragments from both gram-positive and gram-negative microorganisms.—Grunfeld, C., M. Marshall, J. K. Shigenaga, A. H. Moser, P. Tobias, and K. R. Feingold. Lipoproteins inhibit macrophage activation by lipoteichoic acid. J. Lipid Res. 1999. 40: 245–252.
Supplementary key words:
lipoproteins, lipoteichoic acid, lipopolysaccharide, tumor necrosis factor, infection
Copyright © 1999 by Lipid Research, Inc.
Original Article
Lipoproteins inhibit macrophage activation by lipoteichoic acid
Carl Grunfelda,
Maureen Marshalla,
Judy K. Shigenagaa,
Arthur H. Mosera,
Peter Tobiasb, and
Kenneth R. Feingolda
a Department of Medicine, Medical Service, Department of Veterans Affairs Medical Center, San Francisco, CA 94121
a University of California, San Francisco, and Metabolism Section, Medical Service, Department of Veterans Affairs Medical Center, San Francisco, CA 94121
b Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Wang, X. Zhu, G. Wu, L. Shen, and B. Chen Effect of lipid-bound apoA-I cysteine mutants on lipopolysaccharide-induced endotoxemia in mice J. Lipid Res., August 1, 2008; 49(8): 1640 - 1645. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zorko and R. Jerala Alexidine and chlorhexidine bind to lipopolysaccharide and lipoteichoic acid and prevent cell activation by antibiotics J. Antimicrob. Chemother., July 16, 2008; (2008) dkn270v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Gillen, H. S. Courtney, K. Schulze, M. Rohde, M. R. Wilson, A. M. Timmer, C. A. Guzman, V. Nizet, G. S. Chhatwal, and M. J. Walker Opacity Factor Activity and Epithelial Cell Binding by the Serum Opacity Factor Protein of Streptococcus pyogenes Are Functionally Discrete J. Biol. Chem., March 7, 2008; 283(10): 6359 - 6366. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Thompson and R. L. Kitchens Native High-Density Lipoprotein Augments Monocyte Responses to Lipopolysaccharide (LPS) by Suppressing the Inhibitory Activity of LPS-Binding Protein J. Immunol., October 1, 2006; 177(7): 4880 - 4887. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Hasty, S. Meron-Sudai, K. H. Cox, T. Nagorna, E. Ruiz-Bustos, E. Losi, H. S. Courtney, E. A. Mahrous, R. Lee, and I. Ofek Monocyte and Macrophage Activation by Lipoteichoic Acid Is Independent of Alanine and Is Potentiated by Hemoglobin J. Immunol., May 1, 2006; 176(9): 5567 - 5576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. S. Seo, J. H. Kim, and M. H. Nahm Platelet-Activating Factor-Acetylhydrolase Can Monodeacylate and Inactivate Lipoteichoic Acid Clin. Vaccine Immunol., April 1, 2006; 13(4): 452 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. S. Courtney, Y.-M. Zhang, M. W. Frank, and C. O. Rock Serum Opacity Factor, a Streptococcal Virulence Factor That Binds to Apolipoproteins A-I and A-II and Disrupts High Density Lipoprotein Structure J. Biol. Chem., March 3, 2006; 281(9): 5515 - 5521. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Khovidhunkit, M.-S. Kim, R. A. Memon, J. K. Shigenaga, A. H. Moser, K. R. Feingold, and C. Grunfeld Thematic review series: The Pathogenesis of Atherosclerosis. Effects of infection and inflammation on lipid and lipoprotein metabolism mechanisms and consequences to the host J. Lipid Res., July 1, 2004; 45(7): 1169 - 1196. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. S. Van Amersfoort, T. J. C. Van Berkel, and J. Kuiper Receptors, Mediators, and Mechanisms Involved in Bacterial Sepsis and Septic Shock Clin. Microbiol. Rev., July 1, 2003; 16(3): 379 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. M. Levels, P. R. Abraham, E. P. van Barreveld, J. C. M. Meijers, and S. J. H. van Deventer Distribution and Kinetics of Lipoprotein-Bound Lipoteichoic Acid Infect. Immun., June 1, 2003; 71(6): 3280 - 3284. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. E. Vreugdenhil, C. H. Rousseau, T. Hartung, J. W. M. Greve, C. van 't Veer, and W. A. Buurman Lipopolysaccharide (LPS)-Binding Protein Mediates LPS Detoxification by Chylomicrons J. Immunol., February 1, 2003; 170(3): 1399 - 1405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Uesugi, M. Froh, G. E. Arteel, B. U. Bradford, M. D. Wheeler, E. Gabele, F. Isayama, and R. G. Thurman Role of Lipopolysaccharide-Binding Protein in Early Alcohol-Induced Liver Injury in Mice J. Immunol., March 15, 2002; 168(6): 2963 - 2969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Morath, A. Geyer, I. Spreitzer, C. Hermann, and T. Hartung Structural Decomposition and Heterogeneity of Commercial Lipoteichoic Acid Preparations Infect. Immun., February 1, 2002; 70(2): 938 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Augusto, K. Le Blay, G. Auger, D. Blanot, and R. Chaby Interaction of bacterial lipopolysaccharide with mouse surfactant protein C inserted into lipid vesicles Am J Physiol Lung Cell Mol Physiol, October 1, 2001; 281(4): L776 - L785. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. E. Vreugdenhil, A. M. P. Snoek, J. W. M. Greve, and W. A. Buurman Lipopolysaccharide-Binding Protein Is Vectorially Secreted and Transported by Cultured Intestinal Epithelial Cells and Is Present in the Intestinal Mucus of Mice J. Immunol., October 15, 2000; 165(8): 4561 - 4566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. Scott, M. R. Gold, and R. E. W. Hancock Interaction of Cationic Peptides with Lipoteichoic Acid and Gram-Positive Bacteria Infect. Immun., December 1, 1999; 67(12): 6445 - 6453. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Kitchens, G. Wolfbauer, J. J. Albers, and R. S. Munford Plasma Lipoproteins Promote the Release of Bacterial Lipopolysaccharide from the Monocyte Cell Surface J. Biol. Chem., November 26, 1999; 274(48): 34116 - 34122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Memon, W. M. Holleran, Y. Uchida, A. H. Moser, S. Ichikawa, Y. Hirabayashi, C. Grunfeld, and K. R. Feingold Regulation of Glycosphingolipid Metabolism in Liver during the Acute Phase Response J. Biol. Chem., July 9, 1999; 274(28): 19707 - 19713. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
