Correspondence to: Steve E. Humphries

The aims of the study were to investigate associations of the apolipoprotein (apo) A-IV polymorphisms Thr347Ser and Gln360His with anthropomorphic measurements and fasting and postprandial lipids in subjects participating in the European Atherosclerosis Research Study II (EARS II). The allelic frequencies of Ser347 and His360 were 0.185 and 0.067, respectively, in the sample as a whole. There were no significant differences in rare allele frequency between cases (offspring of fathers who suffered a myocardial infarction before the age of 55 years) and controls. Control subjects who were carriers of Ser347 had significantly higher body mass indices (BMIs), waist:hip ratios, total and low density lipoprotein cholesterol and triacylglycerol (TG) concentrations (all P 0.02) than control subjects who were non-carriers, but these effects were not seen in the cases. Control subjects who were carriers of His360 had lower BMIs (P = 0.04), cholesterol and TG concentrations (both P 0.07) compared to non-carriers, but these effects were not seen in the cases. After consumption of an oral fat load, carriers of His360 who were most obese (subjects in the third tertile of BMI) had significantly reduced postprandial lipemia (P < 0.03, as assessed by area under the curve).—Fisher, R. M., H. Burke, V. Nicaud, C. Ehnholm, and S. E. Humphries. Effect of variation in the apoA-IV gene on body mass index and fasting and postprandial lipids in the European Atherosclerosis Research Study II. J. Lipid Res. 1999. 40: 287–294.

Supplementary key words: triacylglycerol, HDL, satiety

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J. Delgado-Lista, F. Perez-Jimenez, J. Ruano, P. Perez-Martinez, F. Fuentes, J. Criado-Garcia, L. D Parnell, A. Garcia-Rios, J. M Ordovas, and J. Lopez-Miranda Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men J. Lipid Res., January 1, 2010; 51(1): 63 - 73. [Abstract] [Full Text] [PDF]

				J. W. Gallagher, R. B. Weinberg, and G. S. Shelness apoA-IV tagged with the ER retention signal KDEL perturbs the intracellular trafficking and secretion of apoB J. Lipid Res., October 1, 2004; 45(10): 1826 - 1834. [Abstract] [Full Text] [PDF]

				W.-m. R. Wong, J. W. Stephens, J. Acharya, S. J. Hurel, S. E. Humphries, and P. J. Talmud The APOA4 T347S variant is associated with reduced plasma TAOS in subjects with diabetes mellitus and cardiovascular disease J. Lipid Res., August 1, 2004; 45(8): 1565 - 1571. [Abstract] [Full Text] [PDF]

				W.-m. R. Wong, E. Hawe, L. K. Li, G. J. Miller, V. Nicaud, L. A. Pennacchio, S. E. Humphries, and P. J. Talmud Apolipoprotein AIV Gene Variant S347 Is Associated With Increased Risk of Coronary Heart Disease and Lower Plasma Apolipoprotein AIV Levels Circ. Res., May 16, 2003; 92(9): 969 - 975. [Abstract] [Full Text] [PDF]

				P. Tilly, C. Sass, M. Vincent-Viry, D. Aguillon, G. Siest, and S. Visvikis Biological and genetic determinants of serum apoC-III concentration: reference limits from the Stanislas Cohort J. Lipid Res., February 1, 2003; 44(2): 430 - 436. [Abstract] [Full Text] [PDF]

				P. J. Talmud, E. Hawe, S. Martin, M. Olivier, G. J. Miller, E. M. Rubin, L. A. Pennacchio, and S. E. Humphries Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides Hum. Mol. Genet., November 15, 2002; 11(24): 3039 - 3046. [Abstract] [Full Text] [PDF]