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Correspondence to:
George H. Rothblat
Numerous studies using a variety of cell/acceptor combinations have demonstrated differences in cholesterol efflux among cells. These studies also show that different acceptors, ranging from simple molecules like cyclodextrins to serum, stimulate efflux through a variety of mechanisms. By combining early observations with data derived from recent studies, it is now possible to formulate a model for cell cholesterol efflux which proposes that an array of different mechanisms, including aqueous diffusion, lipid-free apolipoprotein membrane microsolubilization, and SR-BI-mediated cholesterol exchange contribute to cholesterol flux. In this model the relative importance of each mechanism would be determined both by the cell type and the nature of the extracellular cholesterol acceptor.—Rothblat, G. H., M. de la Llera-Moya, V. Atger, G. Kellner-Weibel, D. L. Williams, and M. C. Phillips. Cell cholesterol efflux: integration of old and new observations provides new insights. J. Lipid Res. 1999. 40: 781–796.
Supplementary key words:
tissue culture cells, cholesterol, efflux, influx, high density lipoprotein, lipoproteins, phospholipid, plasma membrane, cyclodextrin, scavenger receptor class B, type I, review
Copyright © 1999 by Lipid Research, Inc.
Review
Cell cholesterol efflux: integration of old and new observations provides new insights
George H. Rothblata,
Margarita de la Llera-Moyaa,
Veronique Atgerb,
Ginny Kellner-Weibela,
David L. Williamsc, and
Michael C. Phillipsa
a Department of Biochemistry, MCP Hahnemann University, 2900 Queen Lane, Philadelphia, PA 19129
b Laboratoire Central de Biochimie, Hôpital Broussais, Paris, France
c Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, NY
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