HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Dimster-Denk, D. Articles by Ashby, M. Search for Related Content PubMed PubMed Citation Articles by Dimster-Denk, D. Articles by Ashby, M. Social Bookmarking                      What's this?

The Journal of Lipid Research, Vol. 40, 850-860, May 1999
Copyright © 1999 by Lipid Research, Inc.

Original Article

Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reporter Matrix(TM)

Correspondence to: Dago Dimster-Denk

Gene expression profiling is rapidly becoming a mainstay of functional genomic studies. However, there have been relatively few studies of how the data from expression profiles integrate with more classic approaches to examine gene expression. This study used gene expression profiling of a portion of the genome of Saccharomyces cerevisiae to explore the impact of blocks in the isoprenoid biosynthetic pathway on the expression of genes and the regulation of this pathway. Approximately 50% of the genes whose expression was altered by blocks in isoprenoid biosynthesis were genes previously known to participate in the pathway. In contrast to this simple correspondence, the regulatory patterns revealed by different blocks, and in particular by antifungal azoles, was complex in a manner not anticipated by earlier studies.—Dimster-Denk, D., J. Rine, J. Phillips, S. Scherer, P. Cundiff, K. DeBord, D. Gilliland, S. Hickman, A. Jarvis, L. Tong, and M. Ashby. Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reproter Matrix(TM). J. Lipid Res. 1999. 40: 850–860.

Supplementary key words: isoprenoid pathway regulation, genome expression profiling, Saccharomyces cerevisiae

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				G. Giaever, P. Flaherty, J. Kumm, M. Proctor, C. Nislow, D. F. Jaramillo, A. M. Chu, M. I. Jordan, A. P. Arkin, and R. W. Davis Chemogenomic profiling: Identifying the functional interactions of small molecules in yeast PNAS, January 20, 2004; 101(3): 793 - 798. [Abstract] [Full Text] [PDF]

				P. Jain, I. Akula, and T. Edlind Cyclic AMP Signaling Pathway Modulates Susceptibility of Candida Species and Saccharomyces cerevisiae to Antifungal Azoles and Other Sterol Biosynthesis Inhibitors Antimicrob. Agents Chemother., October 1, 2003; 47(10): 3195 - 3201. [Abstract] [Full Text] [PDF]

				Y. Setty, A. E. Mayo, M. G. Surette, and U. Alon Detailed map of a cis-regulatory input function PNAS, June 24, 2003; 100(13): 7702 - 7707. [Abstract] [Full Text] [PDF]

				K. W. Henry, J. T. Nickels, and T. D. Edlind ROX1 and ERG Regulation in Saccharomyces cerevisiae: Implications for Antifungal Susceptibility Eukaryot. Cell, December 1, 2002; 1(6): 1041 - 1044. [Abstract] [Full Text] [PDF]

				W. L. Smith and T. D. Edlind Histone Deacetylase Inhibitors Enhance Candida albicans Sensitivity to Azoles and Related Antifungals: Correlation with Reduction in CDR and ERG Upregulation Antimicrob. Agents Chemother., November 1, 2002; 46(11): 3532 - 3539. [Abstract] [Full Text] [PDF]

				E. Swain, K. Baudry, J. Stukey, V. McDonough, M. Germann, and J. T. Nickels Jr. Sterol-dependent Regulation of Sphingolipid Metabolism in Saccharomyces cerevisiae J. Biol. Chem., July 12, 2002; 277(29): 26177 - 26184. [Abstract] [Full Text] [PDF]

				D. P. Kontoyiannis, G. S. May ;, M. D. De Backer, W. H. M. L. Luyten, and H. V. Bossche Identification of Azole-Responsive Genes by Microarray Technology: Why Are We Missing the Efflux Transporter Genes? Antimicrob. Agents Chemother., December 1, 2001; 45(12): 3674 - 3676. [Full Text] [PDF]

				T. K. Van Dyk, E. J. DeRose, and G. E. Gonye LuxArray, a High-Density, Genomewide Transcription Analysis of Escherichia coli Using Bioluminescent Reporter Strains J. Bacteriol., October 1, 2001; 183(19): 5496 - 5505. [Abstract] [Full Text] [PDF]

				A. Vik and J. Rine Upc2p and Ecm22p, Dual Regulators of Sterol Biosynthesis in Saccharomyces cerevisiae Mol. Cell. Biol., October 1, 2001; 21(19): 6395 - 6405. [Abstract] [Full Text] [PDF]

				S. Kalir, J. McClure, K. Pabbaraju, C. Southward, M. Ronen, S. Leibler, M. G. Surette, and U. Alon Ordering Genes in a Flagella Pathway by Analysis of Expression Kinetics from Living Bacteria Science, June 15, 2001; 292(5524): 2080 - 2083. [Abstract] [Full Text] [PDF]

				M. D. De Backer, T. Ilyina, X.-J. Ma, S. Vandoninck, W. H. M. L. Luyten, and H. Vanden Bossche Genomic Profiling of the Response of Candida albicans to Itraconazole Treatment Using a DNA Microarray Antimicrob. Agents Chemother., June 1, 2001; 45(6): 1660 - 1670. [Abstract] [Full Text]

				C. T. Beh, L. Cool, J. Phillips, and J. Rine Overlapping Functions of the Yeast Oxysterol-Binding Protein Homologues Genetics, March 1, 2001; 157(3): 1117 - 1140. [Abstract] [Full Text]

				T. K. Van Dyk, Y. Wei, M. K. Hanafey, M. Dolan, M. J. G. Reeve, J. A. Rafalski, L. B. Rothman-Denes, and R. A. LaRossa A genomic approach to gene fusion technology PNAS, February 8, 2001; (2001) 41620498. [Abstract] [Full Text]

				G. F. Bammert and J. M. Fostel Genome-Wide Expression Patterns in Saccharomyces cerevisiae: Comparison of Drug Treatments and Genetic Alterations Affecting Biosynthesis of Ergosterol Antimicrob. Agents Chemother., May 1, 2000; 44(5): 1255 - 1265. [Abstract] [Full Text]

				T. K. Van Dyk, Y. Wei, M. K. Hanafey, M. Dolan, M. J. G. Reeve, J. A. Rafalski, L. B. Rothman-Denes, and R. A. LaRossa A genomic approach to gene fusion technology PNAS, February 27, 2001; 98(5): 2555 - 2560. [Abstract] [Full Text] [PDF]