HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Mu, J.-L. Articles by Paigen, B. Search for Related Content PubMed PubMed Citation Articles by Mu, J.-L. Articles by Paigen, B. Social Bookmarking                      What's this?

The Journal of Lipid Research, Vol. 40, 1328-1335, July 1999
Copyright © 1999 by Lipid Research, Inc.

Original Article

Quantitative trait loci analysis for the differences in susceptibility to atherosclerosis and diabetes between inbred mouse strains C57BL/6J and C57BLKS/J

Correspondence to: Beverly Paigen

Mice from the inbred strain C57BLKS/J (BKS) exhibit increased susceptibility to both diabetes and atherosclerosis compared to C57BL/6J (B6) mice. To determine whether the differences in diabetes and atherosclerosis are related, we carried out a cross between B6-db/db and BKS. We selected 99 female F₂-db/db progeny, tested the progeny for plasma lipids, plasma glucose, and fatty-streak lesions, and used quantitative trait loci (QTL) analysis to identify the chromosomal regions associated with these phenotypes. No major QTL were found for total cholesterol, VLDL-cholesterol, or triglycerides. Two suggestive QTL were found for HDL-cholesterol (LOD scores of 2.7 and 2.8), and two suggestive loci were found for plasma glucose (LOD scores of 2.3 and 2.0). Lesion size was not correlated with plasma lipid levels or glucose. Lesion size was determined by a locus at D12Mit49 with a LOD score of 2.5 and a significant likelihood ratio statistic. The gene for apolipoprotein apoB lies within the region, but apoB levels were similar in strains B6 and BKS. The QTL on Chr 12 was confirmed by constructing a congenic strain with BKS alleles in the QTL region on a B6 genetic background.

We conclude that susceptibilities to diabetes and atherosclerosis are not conferred by the same genes in these strains and that a major gene on Chr 12, which we name Ath6, determines the difference in atherosclerosis susceptibility.—Mu, J-L., J. K. Naggert, K. L. Svenson, G. B. Collin, J. H. Kim, C. McFarland, P. M. Nishina, D. M. Levine, K. J. Williams, and B. Paigen. Quantitative trait loci analysis for the differences in susceptibility to atherosclerosis and diabetes between inbred mouse strains C57BL/6J and C57 BLKS/J. J. Lipid Res. 1999. 40: 1328;–1335.

Supplementary key words: high density lipoprotein, very low density lipoprotein, genetics, diabetes, glucose, apoB, Ath6

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				C. Schmidt, N. P. Gonzaludo, S. Strunk, S. Dahm, J. Schuchhardt, F. Kleinjung, S. Wuschke, H.-G. Joost, and H. Al-Hasani A meta-analysis of QTL for diabetes-related traits in rodents Physiol Genomics, June 10, 2008; 34(1): 42 - 53. [Abstract] [Full Text] [PDF]

				L. M. Holdt, J. Thiery, J. L. Breslow, and D. Teupser Increased ADAM17 mRNA Expression and Activity Is Associated With Atherosclerosis Resistance in LDL-Receptor Deficient Mice Arterioscler. Thromb. Vasc. Biol., June 1, 2008; 28(6): 1097 - 1103. [Abstract] [Full Text] [PDF]

				J. E. Kanter, F. Johansson, R. C. LeBoeuf, and K. E. Bornfeldt Do Glucose and Lipids Exert Independent Effects on Atherosclerotic Lesion Initiation or Progression to Advanced Plaques? Circ. Res., March 30, 2007; 100(6): 769 - 781. [Abstract] [Full Text] [PDF]

				S. M. Clee and A. D. Attie The Genetic Landscape of Type 2 Diabetes in Mice Endocr. Rev., February 1, 2007; 28(1): 48 - 83. [Abstract] [Full Text] [PDF]

				D. Teupser, M. Tan, A. D. Persky, and J. L. Breslow Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice PNAS, January 3, 2006; 103(1): 123 - 128. [Abstract] [Full Text] [PDF]

				A. K. Srivastava, S. Mohan, G. L. Masinde, H. Yu, and D. J. Baylink Identification of quantitative trait loci that regulate obesity and serum lipid levels in MRL/MpJ x SJL/J inbred mice J. Lipid Res., January 1, 2006; 47(1): 123 - 133. [Abstract] [Full Text] [PDF]

				G. B. Collin, T. P. Maddatu, S. Sen, and J. K. Naggert Genetic modifiers interact with Cpefat to affect body weight, adiposity, and hyperglycemia Physiol Genomics, July 14, 2005; 22(2): 182 - 190. [Abstract] [Full Text] [PDF]

				R. C. Davis, E. E. Schadt, A. C.L. Cervino, M. Peterfy, and A. J. Lusis Ultrafine Mapping of SNPs From Mouse Strains C57BL/6J, DBA/2J, and C57BLKS/J for Loci Contributing to Diabetes and Atherosclerosis Susceptibility Diabetes, April 1, 2005; 54(4): 1191 - 1199. [Abstract] [Full Text] [PDF]

				M. D. Breyer, E. Bottinger, F. C. Brosius III, T. M. Coffman, R. C. Harris, C. W. Heilig, K. Sharma, and for the AMDCC Mouse Models of Diabetic Nephropathy J. Am. Soc. Nephrol., January 1, 2005; 16(1): 27 - 45. [Abstract] [Full Text] [PDF]

				N. Ishimori, R. Li, P. M. Kelmenson, R. Korstanje, K. A. Walsh, G. A. Churchill, K. Forsman-Semb, and B. Paigen Quantitative trait loci that determine plasma lipids and obesity in C57BL/6J and 129S1/SvImJ inbred mice J. Lipid Res., September 1, 2004; 45(9): 1624 - 1632. [Abstract] [Full Text] [PDF]

				N. Ishimori, R. Li, P. M. Kelmenson, R. Korstanje, K. A. Walsh, G. A. Churchill, K. Forsman-Semb, and B. Paigen Quantitative Trait Loci Analysis for Plasma HDL-Cholesterol Concentrations and Atherosclerosis Susceptibility Between Inbred Mouse Strains C57BL/6J and 129S1/SvImJ Arterioscler. Thromb. Vasc. Biol., January 1, 2004; 24(1): 161 - 166. [Abstract] [Full Text] [PDF]

				H. Allayee, A. Ghazalpour, and A. J. Lusis Using Mice to Dissect Genetic Factors in Atherosclerosis Arterioscler. Thromb. Vasc. Biol., September 1, 2003; 23(9): 1501 - 1509. [Abstract] [Full Text] [PDF]

				J. D. Smith, D. James, H. M. Dansky, K. M. Wittkowski, K. J. Moore, and J. L. Breslow In Silico Quantitative Trait Locus Map for Atherosclerosis Susceptibility in Apolipoprotein E-Deficient Mice Arterioscler. Thromb. Vasc. Biol., January 1, 2003; 23(1): 117 - 122. [Abstract] [Full Text] [PDF]

				A. C.M. Bonne, M. G. den Bieman, G. F. Gillissen, A. Lankhorst, C. J. Kenyon, B. F.M. van Zutphen, and H. A. van Lith Quantitative Trait Loci Influencing Blood and Liver Cholesterol Concentration in Rats Arterioscler. Thromb. Vasc. Biol., December 1, 2002; 22(12): 2072 - 2079. [Abstract] [Full Text] [PDF]

				F. Sugiyama, G. A. Churchill, R. Li, L. J. M. Libby, T. Carver, K.-I. Yagami, S. W. M. John, and B. Paigen QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice Physiol Genomics, July 12, 2002; 10(1): 5 - 12. [Abstract] [Full Text] [PDF]

				H. M. Dansky, P. Shu, M. Donavan, J. Montagno, D. L. Nagle, J. S. Smutko, N. Roy, S. Whiteing, J. Barrios, T. J. McBride, et al. A Phenotype-Sensitizing Apoe-Deficient Genetic Background Reveals Novel Atherosclerosis Predisposition Loci in the Mouse Genetics, April 1, 2002; 160(4): 1599 - 1608. [Abstract] [Full Text] [PDF]

				J. L. Breslow Genetic Differences in Endothelial Cells May Determine Atherosclerosis Susceptibility Circulation, July 4, 2000; 102(1): 5 - 6. [Full Text] [PDF]

				K. Reue, P. Xu, X.-P. Wang, and B. G. Slavin Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene J. Lipid Res., July 1, 2000; 41(7): 1067 - 1076. [Abstract] [Full Text]