HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ostlund, R. E. Articles by Stenson, W. F. Search for Related Content PubMed PubMed Citation Articles by Ostlund, R. E., , Jr. Articles by Stenson, W. F. Social Bookmarking                      What's this?

The Journal of Lipid Research, Vol. 40, 1453-1458, August 1999
Copyright © 1999 by Lipid Research, Inc.

Original Article

Cholesterol absorption efficiency declines at moderate dietary doses in normal human subjects

Correspondence to: Richard E. Ostlund, Jr.

While unphysiologically large cholesterol doses are known to reduce percent cholesterol absorption, smaller amounts are reported to have no effect in human subjects. To determine the dose;–response relation between dietary cholesterol consumed and the efficiency of intestinal cholesterol absorption, we fed 18 normal subjects two test meals containing different amounts of natural cholesterol. In each test pentadeuterated cholesterol tracer was given orally, hexadeuterated cholesterol tracer was given intravenously, and the tracer ratio was measured in plasma 4 days later by gas chromatography/negative ion mass spectrometry. Baseline cholesterol absorption in the presence of 26 mg cholesterol tracer was 40.7 ± 2.3%. This decreased by 4.9 percentage points (P = 0.05) when a total of 188 mg cholesterol was included in the meal and by 15.6 percentage points (P = 0.006) when 421 mg cholesterol was given, showing that the efficiency of cholesterol absorption declines appreciably even with modest increases in cholesterol dose. Considerable variation was noted in the response of different subjects and, on the higher cholesterol dose, dietary cholesterol absorption varied 5-fold from 40 mg to 212 mg. Fasting plasma insulin was correlated with the ability to absorb higher cholesterol doses without loss of efficiency (r_s = 0.700, P = 0.036).

Percent cholesterol absorption in a single meal is significantly influenced by the amount of cholesterol in that meal, suggesting that acute dietary factors influencing cholesterol absorption need further study.—Ostlund, R. E., Jr., M. S. Bosner, and W. F. Stenson. Cholesterol absorption efficiency declines at moderate dietary doses in normal human subjects. J. Lipid Res. 1999. 40: 1453;–1458.

Supplementary key words: cholesterol, absorption, diet, spectrum analysis, mass, deuterium, insulin

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				T. Sudhop, M. Reber, D. Tribble, A. Sapre, W. Taggart, P. Gibbons, T. Musliner, K. von Bergmann, and D. Lutjohann Changes in cholesterol absorption and cholesterol synthesis caused by ezetimibe and/or simvastatin in men J. Lipid Res., October 1, 2009; 50(10): 2117 - 2123. [Abstract] [Full Text] [PDF]

				R. J. Kirby, P. N. Howles, and D. Y. Hui Rate of gastric emptying influences dietary cholesterol absorption efficiency in selected inbred strains of mice J. Lipid Res., January 1, 2004; 45(1): 89 - 98. [Abstract] [Full Text] [PDF]

				J F Miquel, M Moreno, L Amigo, H Molina, P Mardones, I I Wistuba, and A Rigotti Expression and regulation of scavenger receptor class B type I (SR-BI) in gall bladder epithelium Gut, July 1, 2003; 52(7): 1017 - 1024. [Abstract] [Full Text]

				K. von Bergmann, D. Lutjohann, B. Lindenthal, and A. Steinmetz Efficiency of intestinal cholesterol absorption in humans is not related to apoE phenotype J. Lipid Res., January 1, 2003; 44(1): 193 - 197. [Abstract] [Full Text] [PDF]

				R. E Ostlund Jr, S. B Racette, A. Okeke, and W. F Stenson Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans Am. J. Clinical Nutrition, June 1, 2002; 75(6): 1000 - 1004. [Abstract] [Full Text] [PDF]

				K. L. Herron, S. Vega-Lopez, K. Conde, T. Ramjiganesh, S. Roy, N. S. Shachter, and M. L. Fernandez Pre-Menopausal Women, Classified as Hypo- or Hyper-Responders, do not Alter their LDL/HDL Ratio Following a High Dietary Cholesterol Challenge J. Am. Coll. Nutr., June 1, 2002; 21(3): 250 - 258. [Abstract] [Full Text] [PDF]