|
 |
|
|||||||
|
|||||||||
Correspondence to:
K. Cianflone
Acylation stimulating protein (ASP) is a 76 amino acid fragment of the third component of complement (C3) which is generated by the interaction of adipsin and factor B with C3. In vitro studies have shown that ASP can markedly increase triglyceride synthesis in adipocytes. To test the ASP pathway in vivo, C3-deficient mice, and therefore ASP-deficient mice, were generated and oral fat loads were conducted in wild-type (C3+/+) and mutant (C3-/-) animals. The principal results were: 1) postprandial triglyceride clearance was significantly delayed in mutant compared to wild-type mice; 2) this difference was more pronounced in males compared to females; 3) in both males and females, the differences were more pronounced in the second half of the postprandial period; 4) fasting and postprandial free fatty acid (FFA) were higher in C3(-/-) than in C3(+/+) males; and 5) intraperitoneal administration of ASP accelerated triglyceride clearance in C3(-/-) males.
The data are consistent therefore, with the hypothesis that the ASP pathway is an important physiologic determinant of normal postprandial triglyceride clearance.—Murray, I., A. D. Sniderman, and K. Cianflone. Mice lacking acylation stimulating protein (ASP) have delayed postprandial triglyceride clearance. J. Lipid Res. 1999. 40: 1671;–1676.
Supplementary key words:
complement C3a, transgenic, alimentary lipemia
Copyright © 1999 by Lipid Research, Inc.
Original Article
Mice lacking acylation stimulating protein (ASP) have delayed postprandial triglyceride clearance
I. Murraya,
A. D. Snidermana, and
K. Cianflonea
a Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, Quebec, Canada H3A 1A1
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Mamane, C. Chung Chan, G. Lavallee, N. Morin, L.-J. Xu, J. Huang, R. Gordon, W. Thomas, J. Lamb, E. E. Schadt, et al. The C3a Anaphylatoxin Receptor Is a Key Mediator of Insulin Resistance and Functions by Modulating Adipose Tissue Macrophage Infiltration and Activation Diabetes, September 1, 2009; 58(9): 2006 - 2017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Roy, S. Paglialunga, A. Fisette, P. Schrauwen, E. Moonen-Kornips, J. St-Onge, M. K. Hesselink, D. Richard, D. R. Joanisse, and K. Cianflone Shift in metabolic fuel in acylation-stimulating protein-deficient mice following a high-fat diet Am J Physiol Endocrinol Metab, June 1, 2008; 294(6): E1051 - E1059. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Paglialunga, A. Fisette, Y. Yan, Y. Deshaies, J.-F. Brouillette, M. Pekna, and K. Cianflone Acylation-stimulating protein deficiency and altered adipose tissue in alternative complement pathway knockout mice Am J Physiol Endocrinol Metab, March 1, 2008; 294(3): E521 - E529. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Paglialunga, P. Schrauwen, C. Roy, E. Moonen-Kornips, H. Lu, M. K C Hesselink, Y. Deshaies, D. Richard, and K. Cianflone Reduced adipose tissue triglyceride synthesis and increased muscle fatty acid oxidation in C5L2 knockout mice J. Endocrinol., August 1, 2007; 194(2): 293 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Wernstedt, B. Olsson, M. Jernas, S. Paglialunga, L. M. S. Carlsson, U. Smith, K. Cianflone, K. Wallenius, and V. Wallenius Increased Levels of Acylation-Stimulating Protein in Interleukin-6-Deficient (IL-6-/-) Mice Endocrinology, June 1, 2006; 147(6): 2690 - 2695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-H. Yu and H. N. Ginsberg Adipocyte Signaling and Lipid Homeostasis: Sequelae of Insulin-Resistant Adipose Tissue Circ. Res., May 27, 2005; 96(10): 1042 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Li, P. C. Pircher, I. G. Schulman, and S. K. Westin Regulation of Complement C3 Expression by the Bile Acid Receptor FXR J. Biol. Chem., March 4, 2005; 280(9): 7427 - 7434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Faraj and K. Cianflone Differential regulation of fatty acid trapping in mouse adipose tissue and muscle by ASP Am J Physiol Endocrinol Metab, July 1, 2004; 287(1): E150 - E159. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Persson, J. Boren, A.-K. L. Robertson, V. Wallenius, G. K. Hansson, and M. Pekna Lack of Complement Factor C3, but Not Factor B, Increases Hyperlipidemia and Atherosclerosis in Apolipoprotein E-/- Low-Density Lipoprotein Receptor-/- Mice Arterioscler Thromb Vasc Biol, June 1, 2004; 24(6): 1062 - 1067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Faraj, A. D. Sniderman, and K. Cianflone ASP enhances in situ lipoprotein lipase activity by increasing fatty acid trapping in adipocytes J. Lipid Res., April 1, 2004; 45(4): 657 - 666. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Cianflone, R. Zakarian, C. Couillard, B. Delplanque, J.-P. Despres, and A. Sniderman Fasting acylation-stimulating protein is predictive of postprandial triglyceride clearance J. Lipid Res., January 1, 2004; 45(1): 124 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Valet, G. Tavernier, I. Castan-Laurell, J. S. Saulnier-Blache, and D. Langin Understanding adipose tissue development from transgenic animal models J. Lipid Res., June 1, 2002; 43(6): 835 - 860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Murray, P. J. Havel, A. D. Sniderman, and K. Cianflone Reduced Body Weight, Adipose Tissue, and Leptin Levels Despite Increased Energy Intake in Female Mice Lacking Acylation-Stimulating Protein Endocrinology, March 1, 2000; 141(3): 1041 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Murray, A. D. Sniderman, P. J. Havel, and K. Cianflone Acylation Stimulating Protein (ASP) Deficiency Alters Postprandial and Adipose Tissue Metabolism in Male Mice J. Biol. Chem., December 17, 1999; 274(51): 36219 - 36225. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |