HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schuelke, M. Articles by Brigelius-Flohé, R. Search for Related Content PubMed PubMed Citation Articles by Schuelke, M. Articles by Brigelius-Flohé, R. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 41, 1543-1551, October 2000
Copyright © 2000 by Lipid Research, Inc.

Original Article

Urinary -tocopherol metabolites in -tocopherol transfer protein-deficient patients

Correspondence to: Regina Brigelius-Flohé

Patients with -tocopherol transfer protein (-TTP) defects experience neurological symptoms characteristic of vitamin E deficiency and depend on continuous high -tocopherol supplements. We investigated the excretion of 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman (-CEHC), a urinary metabolite of -tocopherol, as a putative marker for the -tocopherol status of -TTP-deficient patients and control subjects. In three patients vitamin E supplementation was stopped for short periods of time, during which plasma -tocopherol concentrations and urinary -CEHC excretion were measured. In the patients, plasma -tocopherol decreased below normal (<5 µmol/l) but -CEHC excretion remained above the range of unsupplemented control subjects (0.118;–0.306 mg/day, n = 6). In healthy subjects, however, -CEHC excretion was increased only after surpassing a plasma -tocopherol threshold of 30;–40 µmol/l. Such a threshold did not exist in patients. The general mechanism of -tocopherol degradation did not appear to differ between patients and control subjects.

The presumed mechanism of - and subsequent ß-oxidation was supported by the detection of -CPHC, an -CEHC homolog with a side chain longer by 3 carbon atoms, both in supplemented patients and in control subjects. — Schuelke, M., A. Elsner, B. Finckh, A. Kohlschütter, C. Hübner, and R. Brigelius-Flohé. Urinary -tocopherol metabolites in -tocopherol transfer protein-deficient patients. J. Lipid Res. 2000. 41: 1543;–1551.

Supplementary key words: -tocopherol, -tocopherol metabolites, -CEHC, -tocopherol transfer protein, AVED patients

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. J Clifford, F. F de Moura, C. C Ho, J. C Chuang, J. Follett, J. G Fadel, and J. A Novotny A feasibility study quantifying in vivo human {alpha}-tocopherol metabolism Am. J. Clinical Nutrition, December 1, 2006; 84(6): 1430 - 1441. [Abstract] [Full Text] [PDF]

				R. S Bruno, S. W Leonard, J. Li, T. M Bray, and M. G Traber Lower plasma {alpha}-carboxyethyl-hydroxychroman after deuterium-labeled {alpha}-tocopherol supplementation suggests decreased vitamin E metabolism in smokers Am. J. Clinical Nutrition, May 1, 2005; 81(5): 1052 - 1059. [Abstract] [Full Text] [PDF]

				S. W. Leonard, E. Gumpricht, M. W. Devereaux, R. J. Sokol, and M. G. Traber Quantitation of rat liver vitamin E metabolites by LC-MS during high-dose vitamin E administration J. Lipid Res., May 1, 2005; 46(5): 1068 - 1075. [Abstract] [Full Text] [PDF]

				D. J. Harrington, R. Soper, C. Edwards, G. F. Savidge, S. J. Hodges, and M. J. Shearer Determination of the urinary aglycone metabolites of vitamin K by HPLC with redox-mode electrochemical detection J. Lipid Res., May 1, 2005; 46(5): 1053 - 1060. [Abstract] [Full Text] [PDF]

				R. S Bruno, R. Ramakrishnan, T. J Montine, T. M Bray, and M. G Traber {alpha}-Tocopherol disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status Am. J. Clinical Nutrition, January 1, 2005; 81(1): 95 - 103. [Abstract] [Full Text] [PDF]

				R. Brigelius-Flohe, F. J Kelly, J. T Salonen, J. Neuzil, J.-M. Zingg, and A. Azzi The European perspective on vitamin E: current knowledge and future research Am. J. Clinical Nutrition, October 1, 2002; 76(4): 703 - 716. [Abstract] [Full Text] [PDF]

				M. Birringer, P. Pfluger, D. Kluth, N. Landes, and R. Brigelius-Flohe Identities and Differences in the Metabolism of Tocotrienols and Tocopherols in HepG2 Cells J. Nutr., October 1, 2002; 132(10): 3113 - 3118. [Abstract] [Full Text] [PDF]

				Q. Jiang, S. Christen, M. K Shigenaga, and B. N Ames {gamma}-Tocopherol, the major form of vitamin E in the US diet, deserves more attention Am. J. Clinical Nutrition, December 1, 2001; 74(6): 714 - 722. [Abstract] [Full Text]