Original Article

PLTP activity in premenopausal women: relationship with lipoprotein lipase, HDL, LDL, body fat, and insulin resistance

Correspondence to: John J. Albers

Plasma phospholipid transfer protein (PLTP) is thought to play a major role in the facilitated transfer of phospholipids between lipoproteins and in the modulation of high density lipoprotein (HDL) particle size and composition. However, little has been reported concerning the relationships of PLTP with plasma lipoprotein parameters, lipolytic enzymes, body fat distribution, insulin, and glucose in normolipidemic individuals, particularly females. In the present study, 50 normolipidemic healthy premenopausal females were investigated. The relationships between the plasma PLTP activity and selected variables were assessed. PLTP activity was significantly and positively correlated with low density lipoprotein (LDL) cholesterol (r_s = 0.53), apoB (r_s = 0.44), glucose (r_s = 0.40), HDL cholesterol (r_s = 0.38), HDL₃ cholesterol (r_s = 0.37), lipoprotein lipase activity (r_s = 0.36), insulin (r_s = 0.33), subcutaneous abdominal fat (r_s = 0.36), intra-abdominal fat (r_s = 0.29), and body mass index (r_s = 0.29). HDL₂ cholesterol, triglyceride, and hepatic lipase were not significantly related to PLTP activity. As HDL₂ can be decreased by hepatic lipase and hepatic lipase is increased in obesity with increasing intra-abdominal fat, the participants were divided into sub-groups of non-obese (n = 35) and obese (n = 15) individuals and the correlation of PLTP with HDL₂ cholesterol was re-examined. In the non-obese subjects, HDL₂ cholesterol was found to be significantly and positively related to PLTP activity (r_s = 0.44). Adjustment of the HDL₂ values for the effect of hepatic lipase activity resulted in a significant positive correlation between PLTP and HDL₂ (r_s = 0.41), indicating that the strength of the relationship between PLTP activity and HDL₂ can be reduced by the opposing effect of hepatic lipase on HDL₂ concentrations.

We conclude that PLTP-facilitated lipid transfer activity is related to HDL and LDL metabolism, as well as lipoprotein lipase activity, adiposity, and insulin resistance.—Murdoch, S. J., M. C. Carr, J. E. Hokanson, J. D. Brunzell, and J. J. Albers. PLTP activity in premenopausal women: relationship with lipoprotein lipase, HDL, LDL, body fat, and insulin resistance. J. Lipid Res. 2000. 41: 237;–244.

Supplementary key words: phospholipid transfer protein, HDL, LDL, lipoprotein lipase, insulin resistance, body fat

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