| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Correspondence to:
Aldons J. Lusis
Familial combined hyperlipidemia (FCH) is a common genetic lipid disorder with a frequency of 1;–2% in the population. In addition to the hypercholesterolemia and/or hypertriglyceridemia that affected individuals exhibit, small, dense LDL particles and decreased HDL-cholesterol levels are traits frequently associated with FCH. Recently, we reported that families with FCH and families enriched for coronary artery disease (CAD) share genetic determinants for the atherogenic lipoprotein phenotype (ALP), a profile presenting with small, dense LDL particles, decreased HDL-cholesterol levels, and increased triglyceride levels. Other studies in normolipidemic populations have shown that the hepatic lipase (HL) gene is linked to HDL-cholesterol levels and that a polymorphism within the HL promoter (-514C
Our results provide support that ALP is a multigenic trait and suggest that the relationship between small, dense LDL particles, HDL-cholesterol, and triglyceride levels in FCH families is due, in part, to common genetic factors.—Allayee, H., K. M. Dominguez, B. E. Aouizerat, R. M. Krauss, J. I. Rotter, J. Lu, R. M. Cantor, T. W. A. de Bruin, and A. J. Lusis. Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia. J. Lipid Res. 2000. 41: 245;–252.
Supplementary key words:
familial combined hyperlipidemia, atherogenic lipoprotein phenotype, hepatic lipase, genetic linkage analysis
Copyright © 2000 by Lipid Research, Inc.
Original Article
Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia
Hooman Allayeea,b,c,e,
Kathlynn M. Domingueza,b,c,e,
Bradley E. Aouizerata,b,c,e,
Ronald M. Kraussf,
Jerome I. Rotterg,
Jinyan Lug,
Rita M. Cantorc,d,
Tjerk W. A. de Bruinh, and
Aldons J. Lusisa,b,c,e
a Departments of Microbiology and Molecular Genetics, University of California, Los Angeles, CA 90095
b Medicine, University of California, Los Angeles, CA 90095
c Human Genetics, University of California, Los Angeles, CA 90095
d Pediatrics, University of California, Los Angeles, CA 90095
e Molecular Biology Institute, University of California, Los Angeles, CA 90095
f Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA
g Division of Medical Genetics, Steven Spielberg Pediatric Research Center, Los Angeles, CA
h Departments of Medicine and Endocrinology, Academic Hospital, Maastricht 6202 HX, The Netherlands
T) is associated with increased HDL-cholesterol levels as well as larger, more buoyant LDL particles. In the present study, we tested whether the HL gene locus also contributes to ALP in a series of Dutch FCH families using nonparametric sibpair linkage analysis and association analysis. Evidence for linkage of LDL particle size (P < 0.019), HDL-cholesterol (P < 0.003), and triglyceride levels (P < 0.026) to the HL gene locus was observed. A genome scan in a subset of these families exhibited evidence for linkage of PPD (LOD = 2.2) and HDL-cholesterol levels (LOD = 1.2) to the HL gene locus as well. The -514CT promoter polymorphism was significantly associated (P < 0.0001) with higher HDL-cholesterol levels in the unrelated males of this population, but not in unrelated females. No association was observed between the polymorphism and LDL particle size or triglyceride levels. 
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  I. J. Kullo, K. Ding, E. Boerwinkle, S. T. Turner, and M. de Andrade Quantitative trait loci influencing low density lipoprotein particle size in African Americans J. Lipid Res., July 1, 2006; 47(7): 1457 - 1462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Krauss Dietary and Genetic Probes of Atherogenic Dyslipidemia Arterioscler. Thromb. Vasc. Biol., November 1, 2005; 25(11): 2265 - 2272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yu, D. F. Wyszynski, D. M. Waterworth, S. D. Wilton, P. J. Barter, Y. A. Kesaniemi, R. W. Mahley, R. McPherson, G. Waeber, T. P. Bersot, et al. Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic dyslipidemia J. Lipid Res., October 1, 2005; 46(10): 2202 - 2213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Shearman, S. Demissie, L. A. Cupples, I. Peter, C. H. Schmid, J. M. Ordovas, M. E. Mendelsohn, and D. E. Housman Tobacco smoking, estrogen receptor {alpha} gene variation and small low density lipoprotein level Hum. Mol. Genet., August 15, 2005; 14(16): 2405 - 2413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Bosse, Y. C. Chagnon, J.-P. Despres, T. Rice, D. C. Rao, C. Bouchard, L. Perusse, and M.-C. Vohl Compendium of genome-wide scans of lipid-related phenotypes: adding a new genome-wide search of apolipoprotein levels J. Lipid Res., December 1, 2004; 45(12): 2174 - 2184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. T. Schroeder, L. Zheng, M. D. Ong, C. Martinez, C. Flores, Y. Stewart, C. Azen, and F. R. Sattler Effects of Androgen Therapy on Adipose Tissue and Metabolism in Older Men J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 4863 - 4872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang, P. Gargalovic, J. Wong, J. L. Gu, X. Wu, H. Qi, P. Wen, L. Xi, B. Tan, R. Gogliotti, et al. Hyplip2, a New Gene for Combined Hyperlipidemia and Increased Atherosclerosis Arterioscler. Thromb. Vasc. Biol., October 1, 2004; 24(10): 1928 - 1934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Isaacs, F. A. Sayed-Tabatabaei, O. T. Njajou, J. C. M. Witteman, and C. M. van Duijn The -514 C->T Hepatic Lipase Promoter Region Polymorphism and Plasma Lipids: A Meta-Analysis J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 3858 - 3863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Bosse, L. Perusse, and M.-C. Vohl Genetics of LDL particle heterogeneity: from genetic epidemiology to DNA-based variations J. Lipid Res., June 1, 2004; 45(6): 1008 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Mar, P. Pajukanta, H. Allayee, M. Groenendijk, G. Dallinga-Thie, R. M. Krauss, J. S. Sinsheimer, R. M. Cantor, T. W.A. de Bruin, and A. J. Lusis Association of the APOLIPOPROTEIN A1/C3/A4/A5 Gene Cluster With Triglyceride Levels and LDL Particle Size in Familial Combined Hyperlipidemia Circ. Res., April 16, 2004; 94(7): 993 - 999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.M. Georgieva, M.M.J. van Greevenbroek, R.M. Krauss, M.C.G.J. Brouwers, V.M.M.-J. Vermeulen, M.G. Robertus-Teunissen, C.J.H. van der Kallen, and T.W.A. de Bruin Subclasses of Low-Density Lipoprotein and Very Low-Density Lipoprotein in Familial Combined Hyperlipidemia: Relationship to Multiple Lipoprotein Phenotype Arterioscler. Thromb. Vasc. Biol., April 1, 2004; 24(4): 744 - 749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Bos, P. G. Scheffer, D. Vieira, J. M. Dekker, G. Nijpels, M. Diamant, T. Teerlink, C. D.A. Stehouwer, L. M. Bouter, R. J. Heine, et al. The Relationship of Lipoprotein Lipase Activity and LDL size Is Dependent on Glucose Metabolism in an Elderly Population: The Hoorn Study Diabetes Care, March 1, 2004; 27(3): 796 - 798. [Full Text] [PDF]
|
|
|
|
|
|
M. A. Austin, K. L. Edwards, S. A. Monks, K. M. Koprowicz, J. D. Brunzell, A. G. Motulsky, M. C. Mahaney, and J. E. Hixson Genome-wide scan for quantitative trait loci influencing LDL size and plasma triglyceride in familial hypertriglyceridemia J. Lipid Res., November 1, 2003; 44(11): 2161 - 2168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Soro, M. Jauhiainen, C. Ehnholm, and M.-R. Taskinen Determinants of low HDL levels in familial combined hyperlipidemia J. Lipid Res., August 1, 2003; 44(8): 1536 - 1544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Aouizerat and J. P. Kane Apolipoprotein A-II: Active or Passive Role in Familial Combined Hyperlipidemia Circ. Res., June 13, 2003; 92(11): 1179 - 1181. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Bosse, L. Perusse, J.-P. Despres, B. Lamarche, Y. C. Chagnon, T. Rice, D.C. Rao, C. Bouchard, and M.-C. Vohl Evidence for a Major Quantitative Trait Locus on Chromosome 17q21 Affecting Low-Density Lipoprotein Peak Particle Diameter Circulation, May 13, 2003; 107(18): 2361 - 2368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. R. Sattler, E. T. Schroeder, M. P. Dube, S. V. Jaque, C. Martinez, P. J. Blanche, S. Azen, and R. M. Krauss Metabolic effects of nandrolone decanoate and resistance training in men with HIV Am J Physiol Endocrinol Metab, December 1, 2002; 283(6): E1214 - E1222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Y. Choi, K.-i. Hirata, T. Ishida, T. Quertermous, and A. D. Cooper Endothelial lipase: a new lipase on the block J. Lipid Res., November 1, 2002; 43(11): 1763 - 1769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Jansen, A. J. M. Verhoeven, and E. J. G. Sijbrands Hepatic lipase: a pro- or anti-atherogenic protein? J. Lipid Res., September 1, 2002; 43(9): 1352 - 1362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Berneis and R. M. Krauss Metabolic origins and clinical significance of LDL heterogeneity J. Lipid Res., September 1, 2002; 43(9): 1363 - 1379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-L. Liu, K. Ylitalo, I. Nuotio, R. Salonen, J. T. Salonen, and M.-R. Taskinen Association Between Carotid Intima-Media Thickness and Low-Density Lipoprotein Size and Susceptibility of Low-Density Lipoprotein to Oxidation in Asymptomatic Members of Familial Combined Hyperlipidemia Families Stroke, May 1, 2002; 33(5): 1255 - 1260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Vakkilainen, M. Jauhiainen, K. Ylitalo, I. O. Nuotio, J. S. A. Viikari, C. Ehnholm, and M.-R. Taskinen LDL particle size in familial combined hyperlipidemia: effects of serum lipids, lipoprotein-modifying enzymes, and lipid transfer proteins J. Lipid Res., April 1, 2002; 43(4): 598 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Rainwater, L. J. Martin, and A. G. Comuzzie Genetic Control of Coordinated Changes in HDL and LDL Size Phenotypes Arterioscler. Thromb. Vasc. Biol., November 1, 2001; 21(11): 1829 - 1833. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Pihlajamaki, M. Austin, K. Edwards, and M. Laakso A Major Gene Effect on Fasting Insulin and Insulin Sensitivity in Familial Combined Hyperlipidemia Diabetes, October 1, 2001; 50(10): 2396 - 2401. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. M. Krauss Atherogenic Lipoprotein Phenotype and Diet-Gene Interactions J. Nutr., February 1, 2001; 131(2): 340S - 343. [Abstract] [Full Text]
|
|
|
|
|
|
P. W. F. Wilson Lipids, Lipases, and Obesity : Does Race Matter? Arterioscler. Thromb. Vasc. Biol., August 1, 2000; 20(8): 1854 - 1856. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
