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Correspondence to:
Aldons J. Lusis
Familial combined hyperlipidemia (FCH) is a common genetic lipid disorder with a frequency of 1;–2% in the population. In addition to the hypercholesterolemia and/or hypertriglyceridemia that affected individuals exhibit, small, dense LDL particles and decreased HDL-cholesterol levels are traits frequently associated with FCH. Recently, we reported that families with FCH and families enriched for coronary artery disease (CAD) share genetic determinants for the atherogenic lipoprotein phenotype (ALP), a profile presenting with small, dense LDL particles, decreased HDL-cholesterol levels, and increased triglyceride levels. Other studies in normolipidemic populations have shown that the hepatic lipase (HL) gene is linked to HDL-cholesterol levels and that a polymorphism within the HL promoter (-514C
Our results provide support that ALP is a multigenic trait and suggest that the relationship between small, dense LDL particles, HDL-cholesterol, and triglyceride levels in FCH families is due, in part, to common genetic factors.—Allayee, H., K. M. Dominguez, B. E. Aouizerat, R. M. Krauss, J. I. Rotter, J. Lu, R. M. Cantor, T. W. A. de Bruin, and A. J. Lusis. Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia. J. Lipid Res. 2000. 41: 245;–252.
Supplementary key words:
familial combined hyperlipidemia, atherogenic lipoprotein phenotype, hepatic lipase, genetic linkage analysis
Copyright © 2000 by Lipid Research, Inc.
Original Article
Contribution of the hepatic lipase gene to the atherogenic lipoprotein phenotype in familial combined hyperlipidemia
Hooman Allayeea,b,c,e,
Kathlynn M. Domingueza,b,c,e,
Bradley E. Aouizerata,b,c,e,
Ronald M. Kraussf,
Jerome I. Rotterg,
Jinyan Lug,
Rita M. Cantorc,d,
Tjerk W. A. de Bruinh, and
Aldons J. Lusisa,b,c,e
a Departments of Microbiology and Molecular Genetics, University of California, Los Angeles, CA 90095
b Medicine, University of California, Los Angeles, CA 90095
c Human Genetics, University of California, Los Angeles, CA 90095
d Pediatrics, University of California, Los Angeles, CA 90095
e Molecular Biology Institute, University of California, Los Angeles, CA 90095
f Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA
g Division of Medical Genetics, Steven Spielberg Pediatric Research Center, Los Angeles, CA
h Departments of Medicine and Endocrinology, Academic Hospital, Maastricht 6202 HX, The Netherlands
T) is associated with increased HDL-cholesterol levels as well as larger, more buoyant LDL particles. In the present study, we tested whether the HL gene locus also contributes to ALP in a series of Dutch FCH families using nonparametric sibpair linkage analysis and association analysis. Evidence for linkage of LDL particle size (P < 0.019), HDL-cholesterol (P < 0.003), and triglyceride levels (P < 0.026) to the HL gene locus was observed. A genome scan in a subset of these families exhibited evidence for linkage of PPD (LOD = 2.2) and HDL-cholesterol levels (LOD = 1.2) to the HL gene locus as well. The -514CT promoter polymorphism was significantly associated (P < 0.0001) with higher HDL-cholesterol levels in the unrelated males of this population, but not in unrelated females. No association was observed between the polymorphism and LDL particle size or triglyceride levels. 
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