J. Lipid Res.
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Journal of Lipid Research, Vol. 41, 532-537, April 2000
Copyright © 2000 by Lipid Research, Inc.

Original Article

Microsomal triglyceride transfer protein expression during mouse development

John M. Sheltonb, Mi-Hye Leea, James A. Richardsonc, and Shailendra B. Patela
a Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425-2222
b Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235
c Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235

Correspondence to: Shailendra B. Patel

Feto-maternal transfer of lipophilic nutrients is an important factor in the normal development of the fetus and may be mediated by lipoproteins as carriers of these nutrients. Two proteins that may be important in this process are apolipoprotein B (apoB, the major structural protein of secreted lipoproteins) and microsomal triglyceride transfer protein (MTP) whose normal activity is required for the secretion of apoB-containing lipoproteins. Although no abnormalities of conception and embryonic lethality are known in humans who inherit genetic deficiencies of either of these proteins, homozygous mice bearing knockouts of either apoB or MTP show early embryonic lethality. To characterize the ontogeny of MTP expression during embryonic mouse development, we have used in situ hybridization to characterize the pattern of expression. By using microwave heating of tissue sections to optimize hybridization, we show that there is robust MTP expression in the yolk sac tissues followed by expression in the primordial liver cell nests as early as day 9 post-coitum (E9.5). Intestinal expression is detected around E12.5 and attains full adult expression patterns by E14.5. No expression in any other tissues was observed, including developing heart, kidney, placenta, and maternal decidua.

Thus the pattern of MTP expression is compatible with a role in the transfer of lipophilic nutrients from the yolk sac, prior to hepatic development and to the liver, once the circulatory system has been established.—Shelton, J. M., M-H. Lee, J. A. Richardson, and S. B. Patel. Microsomal triglyceride transfer protein expression during mouse development. J. Lipid Res. 2000. 41: 532;–537.

Supplementary key words: embryonic development, feto-maternal unit, microwave RNA retrieval, riboprobes, in situ hybridization


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