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Journal of Lipid Research, Vol. 41, 1060-1066, July 2000
Copyright © 2000 by Lipid Research, Inc.

Original Article

Leukocyte CD11b expression is not essential for the development of atherosclerosis in mice

Nobuhiko Kuboa, William A. Boisverta, Christie M. Ballantynec, and Linda K. Curtissa,b
a Departments of Immunology, Scripps Research Institute, La Jolla, California 92037
b Vascular Biology, Scripps Research Institute, La Jolla, California 92037
c Speros P. Martel Laboratory of Leukocyte Biology and Department of Medicine, Baylor College of Medicine, Houston, Texas 77030

Correspondence to: Linda K. Curtiss

CD11b is an {alpha} chain of the leukocyte ß2-integrin, Mac-1, which mediates binding and extravasation of leukocytes. Because this event is critical in atherosclerosis, we examined the role of CD11b in lesion formation. Atherosclerosis-susceptible, low density lipoprotein receptor-deficient (LDL-R-/-) mice were irradiated and repopulated with bone marrow cells from CD11b-deficient (CD11b-/-) mice. After 4 weeks, <2% of the peripheral blood leukocytes of the CD11b-/- bone marrow-transplanted LDL-R-/- mice expressed CD11b, whereas ~25% of the CD11b+/+ bone marrow-transplanted LDL-R-/- mice expressed CD11b. After consuming a high-fat diet for 16 weeks the mean lesion aortic valve area, cholesterol accumulation in the aorta, and the degree of intimal macrophage infiltration were similar in mice reconstituted with either CD11b+/+ or CD11b-/- bone marrow cells.

The studies confirm that CD11b expression of bone marrow-derived cells does not influence the development of atherosclerosis in hypercholesterolemic LDL-R-/- mice.—Kubo, N., W. A. Boisvert, C. M. Ballantyne, and L. K. Curtiss. Leukocyte CD11b expression is not essential for the development of atherosclerosis in mice. J. Lipid Res. 2000. 41: 1060–1066.

Supplementary key words: transgenic/knockout, fluorescence-activated cell sorting, in vivo animal models, adhesion molecules, inflammation


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