HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Karpe, F. Articles by Hamsten, A. Search for Related Content PubMed PubMed Citation Articles by Karpe, F. Articles by Hamsten, A. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 42, 17-21, January 2001
Copyright © 2001 by Lipid Research, Inc.

Original Article

Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides

Correspondence to: Fredrik Karpe, at the Oxford Lipid Metabolism Group, Radcliffe Infirmary, Oxford OX2 6HE, UK., fredrik.karpe{at}oxlip.ox.ac.uk (E-mail)

Remnants of triglyceride-rich lipoproteins (TRL) have been implicated in the early development of atherosclerosis. We tested this hypothesis by quantifying the plasma concentration of remnant-like particle cholesterol (RLP-C) in a cohort of healthy 50-year-old men in whom the common carotid artery intima-media thickness (CCA-IMT) was assessed by B-mode ultrasound as a surrogate marker for atherosclerosis. The subjects were given a fat-rich meal to study the generation of RLP-C during postprandial lipemia. Fasting plasma RLP-C and other major fasting plasma lipids and lipoproteins were determined twice, and the mean RLP-C concentration was strongly correlated with CCA-IMT (r = 0.32, P = 0.002). In addition, low density lipoprotein (LDL) cholesterol (r = 0.25, P = 0.01) and plasma triglycerides (r = 0.20, P = 0.05) were significantly related to CCA-IMT. Multivariate analyses showed a triglyceride-independent contribution of RLP-C to CCA-IMT. After fat intake, the median plasma RLP-C concentration was doubled after 3 h. The increase was strongly related to the postprandial generation of TRL apolipoprotein (apo)B-48, and large (S_f 60;–400) TRL apoB-100. The association with CCA-IMT was somewhat stronger for the 3-h RLP-C level than for the fasting RLP-C concentration [r = 0.27, P < 0.01 (3 h) compared with r = 0.22, P < 0.05 (0 h)].

We conclude that the plasma concentration of RLP-C is related to CCA-IMT, independent of plasma triglycerides and LDL cholesterol, in a healthy middle-aged male population. — Karpe, F., S. Boquist, R. Tang, G. M. Bond, U. de Faire, and A. Hamsten. Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides. J. Lipid Res. 2001. 42: 17;–21.

Supplementary key words: triglyceride-rich lipoproteins, vascular wall, alimentary lipemia, chylomicrons, very low density lipoproteins

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. M. J. van Hees, W. H. M. Saris, G. M. Dallinga-Thie, G. B. Hul, J. A. Martinez, J.-M. Oppert, V. Stich, A. Astrup, P. Arner, T. I. A. Sorensen, et al. Fasting and Postprandial Remnant-Like Particle Cholesterol Concentrations in Obese Participants Are Associated with Plasma Triglycerides, Insulin Resistance, and Body Fat Distribution J. Nutr., December 1, 2008; 138(12): 2399 - 2405. [Abstract] [Full Text] [PDF]

				J. de Graaf, G. M. van der Vleuten, E. ter Avest, G. M. Dallinga-Thie, and A. F. H. Stalenhoef High Plasma Level of Remnant-Like Particles Cholesterol in Familial Combined Hyperlipidemia J. Clin. Endocrinol. Metab., April 1, 2007; 92(4): 1269 - 1275. [Abstract] [Full Text] [PDF]

				B. Qin, W. Qiu, R. K. Avramoglu, and K. Adeli Tumor Necrosis Factor-{alpha} Induces Intestinal Insulin Resistance and Stimulates the Overproduction of Intestinal Apolipoprotein B48-Containing Lipoproteins Diabetes, February 1, 2007; 56(2): 450 - 461. [Abstract] [Full Text] [PDF]

				H. Koga, S. Sugiyama, K. Kugiyama, H. Fukushima, K. Watanabe, T. Sakamoto, M. Yoshimura, H. Jinnouchi, and H. Ogawa Elevated levels of remnant lipoproteins are associated with plasma platelet microparticles in patients with type-2 diabetes mellitus without obstructive coronary artery disease Eur. Heart J., April 1, 2006; 27(7): 817 - 823. [Abstract] [Full Text] [PDF]

				C. Imke, B. L. Rodriguez, J. S. Grove, J. R. McNamara, C. Waslien, A. R. Katz, B. Willcox, K. Yano, and J. D. Curb Are Remnant-Like Particles Independent Predictors of Coronary Heart Disease Incidence?: The Honolulu Heart Study Arterioscler. Thromb. Vasc. Biol., August 1, 2005; 25(8): 1718 - 1722. [Abstract] [Full Text] [PDF]

				W. S. Tzou, P. S. Douglas, S. R. Srinivasan, W. Chen, G. Berenson, and J. H. Stein Advanced Lipoprotein Testing Does Not Improve Identification of Subclinical Atherosclerosis in Young Adults: The Bogalusa Heart Study Ann Intern Med, May 3, 2005; 142(9): 742 - 750. [Abstract] [Full Text] [PDF]

				A. Schlitt, M. R. Hojjati, H. von Gizycki, K. J. Lackner, S. Blankenberg, B. Schwaab, J. Meyer, H. J. Rupprecht, and X.-C. Jiang Serum sphingomyelin levels are related to the clearance of postprandial remnant-like particles J. Lipid Res., February 1, 2005; 46(2): 196 - 200. [Abstract] [Full Text] [PDF]

				G. F. Lewis, K. Uffelman, M. Naples, L. Szeto, M. Haidari, and K. Adeli Intestinal Lipoprotein Overproduction, a Newly Recognized Component of Insulin Resistance, Is Ameliorated by the Insulin Sensitizer Rosiglitazone: Studies in the Fructose-Fed Syrian Golden Hamster Endocrinology, January 1, 2005; 146(1): 247 - 255. [Abstract] [Full Text] [PDF]

				G. F. Lewis, M. Naples, K. Uffelman, N. Leung, L. Szeto, and K. Adeli Intestinal Lipoprotein Production Is Stimulated by an Acute Elevation of Plasma Free Fatty Acids in the Fasting State: Studies in Insulin-Resistant and Insulin-Sensitized Syrian Golden Hamsters Endocrinology, November 1, 2004; 145(11): 5006 - 5012. [Abstract] [Full Text] [PDF]

				E. A. Brinton, M. N. Nanjee, and P. N. Hopkins Triglyceride-rich lipoprotein remnant levels and metabolism: Time to adopt these orphan risk factors? J. Am. Coll. Cardiol., June 16, 2004; 43(12): 2233 - 2235. [Full Text] [PDF]

				T.B. Twickler, G.M. Dallinga-Thie, J.S. Cohn, and M.J. Chapman Elevated Remnant-Like Particle Cholesterol Concentration: A Characteristic Feature of the Atherogenic Lipoprotein Phenotype Circulation, April 27, 2004; 109(16): 1918 - 1925. [Full Text] [PDF]

				G. A. Kaysen and J. P. Eiserich The Role of Oxidative Stress-Altered Lipoprotein Structure and Function and Microinflammation on Cardiovascular Risk in Patients with Minor Renal Dysfunction J. Am. Soc. Nephrol., March 1, 2004; 15(3): 538 - 548. [Abstract] [Full Text] [PDF]

				P. Blackburn, B. Lamarche, C. Couillard, A. Pascot, A. Tremblay, J. Bergeron, I. Lemieux, and J.-P. Despres Contribution of Visceral Adiposity to the Exaggerated Postprandial Lipemia of Men With Impaired Glucose Tolerance Diabetes Care, December 1, 2003; 26(12): 3303 - 3309. [Abstract] [Full Text] [PDF]

				T. B. Twickler, M. J. M. Cramer, G. M. Dallinga-Thie, M. J. Chapman, D. W. Erkelens, and H. P. F. Koppeschaar Adult-Onset Growth Hormone Deficiency: Relation of Postprandial Dyslipidemia to Premature Atherosclerosis J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2479 - 2488. [Full Text] [PDF]

				T. B. Twickler, G. M. Dallinga-Thie, F. L. J. Visseren, W. R. de Vries, D. W. Erkelens, and H. P. F. Koppeschaar Induction of Postprandial Inflammatory Response in Adult Onset Growth Hormone Deficiency Is Related to Plasma Remnant-Like Particle-Cholesterol Concentration J. Clin. Endocrinol. Metab., March 1, 2003; 88(3): 1228 - 1233. [Abstract] [Full Text] [PDF]

				G. D. Kolovou, D. Ch. Daskalova, S. A. Iraklianou, E. N. Adamopoulou, N. D. Pilatis, G. C. Hatzigeorgiou, and D. V. Cokkinos Postprandial Lipemia in Hypertension J. Am. Coll. Nutr., February 1, 2003; 22(1): 80 - 87. [Abstract] [Full Text] [PDF]

				References Circulation, December 17, 2002; 106(25): 3373 - 3421. [Full Text]

				M. Haidari, N. Leung, F. Mahbub, K. D. Uffelman, R. Kohen-Avramoglu, G. F. Lewis, and K. Adeli Fasting and Postprandial Overproduction of Intestinally Derived Lipoproteins in an Animal Model of Insulin Resistance. EVIDENCE THAT CHRONIC FRUCTOSE FEEDING IN THE HAMSTER IS ACCOMPANIED BY ENHANCED INTESTINAL DE NOVO LIPOGENESIS AND ApoB48-CONTAINING LIPOPROTEIN OVERPRODUCTION J. Biol. Chem., August 23, 2002; 277(35): 31646 - 31655. [Abstract] [Full Text] [PDF]

				P. R. W. de Sauvage Nolting, M. B. Twickler, G. M. Dallinga-Thie, R. J.A. Buirma, B. A. Hutten, J. J.P. Kastelein, and for the Examination of Probands and Relatives in S Elevated Remnant-Like Particles in Heterozygous Familial Hypercholesterolemia and Response to Statin Therapy Circulation, August 13, 2002; 106(7): 788 - 792. [Abstract] [Full Text] [PDF]

				B. Lundahl, A. Hamsten, and F. Karpe Postprandial Plasma ApoB-48 Levels Are Influenced by a Polymorphism in the Promoter of the Microsomal Triglyceride Transfer Protein Gene Arterioscler. Thromb. Vasc. Biol., February 1, 2002; 22(2): 289 - 293. [Abstract] [Full Text] [PDF]

				I. Jialal and S. Devaraj Remnant Lipoproteins: Measurement and Clinical Significance Clin. Chem., February 1, 2002; 48(2): 217 - 219. [Full Text] [PDF]

				C. Koutsari, F. Karpe, S. M. Humphreys, K. N. Frayn, and A. E. Hardman Exercise Prevents the Accumulation of Triglyceride-Rich Lipoproteins and Their Remnants Seen When Changing to a High-Carbohydrate Diet Arterioscler. Thromb. Vasc. Biol., September 1, 2001; 21(9): 1520 - 1525. [Abstract] [Full Text] [PDF]