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Journal of Lipid Research, Vol. 42, 1513-1520, October 2001
Copyright © 2001 by Lipid Research, Inc.

Thematic Review Article

Role of ABCG1 and other ABCG family members in lipid metabolism

Correspondence to: Gerd Schmitz, To whom correspondence should be addressed., gerd.schmitz{at}klinik.uni-regensburg.de (E-mail)

The molecular cloning and identification of mutations in ATP-binding cassette transporters in hereditary diseases have greatly expanded our knowledge of the normal physiology of intracellular lipid transport processes. In addition to the well-known ATP-binding cassette transporter A1 (ABCA1) molecule, ABC transporters belonging to the ABCG (White) subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be critically involved in the regulation of lipid-trafficking mechanisms in macrophages, hepatocytes, and intestinal mucosa cells. ABCG1, the product of a sterol-induced gene, participates in cholesterol and phospholipid efflux. The ABCG5 and ABCG8 transporters, defective in ß-sitosterolemia, are also now considered interesting targets in the control and influence of total body sterol homeostasis.

In this review, advances referring to the regulation and function of ABCG half-size transporters are summarized and discussed. In addition, new implications for the transcriptional control, as well as the intracellular routing and localization, of these proteins are presented. — Schmitz. G., T. Langmann, and S. Heimerl. Role of ABCG1 and other ABCG family members in lipid metabolism. J. Lipid Res. 2001. 42: 1513–1520.

Supplementary key words: adaptor proteins, Drosophila ABC transporters, gene regulation, macrophage, ß-sitosterolemia, vesicular transport

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