HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Galitzky, J. Articles by Berlan, M. Search for Related Content PubMed PubMed Citation Articles by Galitzky, J. Articles by Berlan, M. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 42, 536-544, April 2001
Copyright © 2001 by Lipid Research, Inc.

Original Article

The lipid-mobilizing effect of atrial natriuretic peptide is unrelated to sympathetic nervous system activation or obesity in young men

Correspondence to: Michel Berlan, berlan{at}cict.fr (E-mail)

We recently demonstrated that natriuretic peptides and especially the atrial natriuretic peptide (ANP) are powerful lipolytic agents on isolated human fat cells. To search for a possible influence of obesity on ANP responsiveness, we compared the lipolytic effects of human ANP (h-ANP) on isolated subcutaneous abdominal adipose tissue (SCAAT) fat cells from young healthy lean and obese men. The lipid-mobilizing effects of an intravenous infusion of h-ANP was studied, as well as various metabolic and cardiovascular parameters that were compared in the same subjects. h-ANP (50 ng/min/kg) was infused iv for 60 min. Microdialysis probes were inserted in SCAAT to measure modifications of the extracellular glycerol concentrations during h-ANP infusion. Spectral analysis of blood pressure and heart rate oscillations that were recorded using digital photoplethysmography were used to assess changes in autonomic nervous system activity. h-ANP induced a marked and similar increase in glycerol and nonesterified fatty acids, and a weak increase in insulin plasma levels in lean and obese men. Plasma norepinephrine concentrations rose similarly during h-ANP infusion in lean and obese men. The effects of h-ANP infusion on the autonomic nervous system were similar in both groups, with an increase in the spectral energy of the low-frequency band of systolic blood pressure variability and a decrease in the spectral energy of the high-frequency band of heart rate. In SCAAT, h-ANP infusion increased extracellular glycerol concentration and decreased blood flow similarly in both groups. The increase in extracellular glycerol observed during h-ANP infusion was not modified when 0.1 mM propranolol was added to the microdialysis probe perfusate to prevent ß-adrenoceptor activation.

These data show that ANP is a potent lipolytic hormone independent of the activation of the sympathetic nervous system, and that obesity did not modify the lipid-mobilizing effect of ANP in young obese subjects. — Galitzky, J., C. Sengenès, C. Thalamas, M. A. Marques, J-M. Senard, M. Lafontan, and M. Berlan. The lipid-mobilizing effect of atrial natriuretic peptide is unrelated to sympathetic nervous system activation or obesity in young men. J. Lipid Res. 2001. 42: 536;–544.

Supplementary key words: adipocyte, ANP, microdialysis, human fat cells

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				C. Moro, F. Pillard, I. de Glisezinski, E. Klimcakova, F. Crampes, C. Thalamas, I. Harant, M.-A. Marques, M. Lafontan, and M. Berlan Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E505 - E513. [Abstract] [Full Text] [PDF]

				C. Moro, F. Pillard, I. de Glisezinski, F. Crampes, C. Thalamas, I. Harant, M.-A. Marques, M. Lafontan, and M. Berlan Atrial natriuretic peptide contribution to lipid mobilization and utilization during head-down bed rest in humans Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R612 - R617. [Abstract] [Full Text] [PDF]

				J. Polak, C. Moro, E. Klimcakova, M. Kovacikova, M. Bajzova, M. Vitkova, Z. Kovacova, R. Sotornik, M. Berlan, N. Viguerie, et al. The atrial natriuretic peptide- and catecholamine-induced lipolysis and expression of related genes in adipose tissue in hypothyroid and hyperthyroid patients Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E246 - E251. [Abstract] [Full Text] [PDF]

				A. Meirhaeghe, M. S. Sandhu, M. I. McCarthy, P. de Groote, D. Cottel, D. Arveiler, J. Ferrieres, C. J. Groves, A. T. Hattersley, G. A. Hitman, et al. Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations Hum. Mol. Genet., June 1, 2007; 16(11): 1343 - 1350. [Abstract] [Full Text] [PDF]

				A. L. Birkenfeld, M. Boschmann, C. Moro, F. Adams, K. Heusser, J. Tank, A. Diedrich, C. Schroeder, G. Franke, M. Berlan, et al. {beta}-Adrenergic and Atrial Natriuretic Peptide Interactions on Human Cardiovascular and Metabolic Regulation J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 5069 - 5075. [Abstract] [Full Text] [PDF]

				C. Moro, J. Polak, J. Hejnova, E. Klimcakova, F. Crampes, V. Stich, M. Lafontan, and M. Berlan Atrial natriuretic peptide stimulates lipid mobilization during repeated bouts of endurance exercise Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E864 - E869. [Abstract] [Full Text] [PDF]

				L. R. Potter, S. Abbey-Hosch, and D. M. Dickey Natriuretic Peptides, Their Receptors, and Cyclic Guanosine Monophosphate-Dependent Signaling Functions Endocr. Rev., February 1, 2006; 27(1): 47 - 72. [Abstract] [Full Text] [PDF]

				T. Nishikimi, N. Maeda, and H. Matsuoka The role of natriuretic peptides in cardioprotection Cardiovasc Res, February 1, 2006; 69(2): 318 - 328. [Abstract] [Full Text] [PDF]

				M. Lafontan, C. Moro, C. Sengenes, J. Galitzky, F. Crampes, and M. Berlan An Unsuspected Metabolic Role for Atrial Natriuretic Peptides: The Control of Lipolysis, Lipid Mobilization, and Systemic Nonesterified Fatty Acids Levels in Humans Arterioscler. Thromb. Vasc. Biol., October 1, 2005; 25(10): 2032 - 2042. [Abstract] [Full Text] [PDF]

				A. L. Birkenfeld, M. Boschmann, C. Moro, F. Adams, K. Heusser, G. Franke, M. Berlan, F. C. Luft, M. Lafontan, and J. Jordan Lipid Mobilization with Physiological Atrial Natriuretic Peptide Concentrations in Humans J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3622 - 3628. [Abstract] [Full Text] [PDF]

				C. Moro, J. Galitzky, C. Sengenes, F. Crampes, M. Lafontan, and M. Berlan Functional and Pharmacological Characterization of the Natriuretic Peptide-Dependent Lipolytic Pathway in Human Fat Cells J. Pharmacol. Exp. Ther., March 1, 2004; 308(3): 984 - 992. [Abstract] [Full Text] [PDF]

				C. Sengenes, A. Bouloumie, H. Hauner, M. Berlan, R. Busse, M. Lafontan, and J. Galitzky Involvement of a cGMP-dependent Pathway in the Natriuretic Peptide-mediated Hormone-sensitive Lipase Phosphorylation in Human Adipocytes J. Biol. Chem., December 5, 2003; 278(49): 48617 - 48626. [Abstract] [Full Text] [PDF]

				C. Sengenes, A. Zakaroff-Girard, A. Moulin, M. Berlan, A. Bouloumie, M. Lafontan, and J. Galitzky Natriuretic peptide-dependent lipolysis in fat cells is a primate specificity Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R257 - R265. [Abstract] [Full Text] [PDF]

				A. K. Kiemer, N. C. Weber, R. Furst, N. Bildner, S. Kulhanek-Heinze, and A. M. Vollmar Inhibition of p38 MAPK Activation via Induction of MKP-1: Atrial Natriuretic Peptide Reduces TNF-{alpha}-Induced Actin Polymerization and Endothelial Permeability Circ. Res., May 3, 2002; 90(8): 874 - 881. [Abstract] [Full Text] [PDF]

				A. K. Kiemer, N. C. Weber, R. Furst, N. Bildner, S. Kulhanek-Heinze, and A. M. Vollmar Inhibition of p38 MAPK Activation via Induction of MKP-1: Atrial Natriuretic Peptide Reduces TNF-{alpha}-Induced Actin Polymerization and Endothelial Permeability Circ. Res., May 3, 2002; 90(8): 874 - 881. [Abstract] [Full Text] [PDF]