Advertisement
J. Lipid Res.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Panousis, C. G.
Right arrow Articles by Zuckerman, S. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Panousis, C. G.
Right arrow Articles by Zuckerman, S. H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Journal of Lipid Research, Vol. 42, 856-863, May 2001
Copyright © 2001 by Lipid Research, Inc.

Original Article

TGF-ß increases cholesterol efflux and ABC-1 expression in macrophage-derived foam cells: opposing the effects of IFN-{gamma}

Constantinos G. Panousisa, Glenn Evansa, and Steven H. Zuckermana
a Division of Cardiovascular Research, Lilly Research Laboratories, Lilly Corporate Center, Building 48/2, Indianapolis, IN 46285

Correspondence to: Steven H. Zuckerman, To whom correspondence should be addressed., Zuckerman_Steven{at}Lilly.com (E-mail)

The regulation of ATP-binding cassette transporter 1 (ABC-1) expression by cytokines present within the microenvironment of the atheroma may play an important role in determining the impact of reverse cholesterol transport on the atherosclerotic lesion. We recently reported that the macrophage-activating cytokine interferon (IFN)-{gamma} inhibited both cholesterol efflux and ABC-1 expression. In the present study, we investigated the effects of transforming growth factor (TGF)-ß, a cytokine also apparent within the atheroma, on cholesterol efflux, ABC-1 expression, and its ability to antagonize the inhibitory effects of IFN-{gamma}. TGF-ß significantly increased cholesterol efflux in macrophage-derived foam cells from apolipoprotein E (apoE) knockout mice, with maximal effects apparent at 300 pg/ml. The increases in efflux occurred without any effect on the passive diffusion component of efflux mediated by ß-cyclodextrin. Furthermore, the increase in cholesterol efflux occurred without any changes in free or esterified cholesterol pools and was consistent with an increase in both ABC-1 message and protein. Finally, TGF-ß was also demonstrated to inhibit the IFN-{gamma}-mediated down-regulation of ABC-1.

These results further demonstrate the importance of cytokine cross-talk to impact the process of reverse cholesterol transport through a multitude of processes including the regulation of ABC-1. — Panousis, C. G., G. Evans, and S. H. Zuckerman. TGF-ß increases cholesterol efflux and ABC-1 expression in macrophage-derived foam cells: opposing the effects of IFN-{gamma}. J. Lipid Res. 2001. 42: 856;–863.

Supplementary key words: inflammation, reverse cholesterol transport, apoA-I, cytokines


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
P. Antonson, T. Jakobsson, T. Almlof, K. Guldevall, K. R. Steffensen, and J.-A. Gustafsson
RAP250 Is a Coactivator in the Transforming Growth Factor {beta} Signaling Pathway That Interacts with Smad2 and Smad3
J. Biol. Chem., April 4, 2008; 283(14): 8995 - 9001.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. Bobik
Transforming Growth Factor-{beta}s and Vascular Disorders
Arterioscler. Thromb. Vasc. Biol., August 1, 2006; 26(8): 1712 - 1720.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
N. N. Singh and D. P. Ramji
Transforming Growth Factor-{beta}-Induced Expression of the Apolipoprotein E Gene Requires c-Jun N-Terminal Kinase, p38 Kinase, and Casein Kinase 2
Arterioscler. Thromb. Vasc. Biol., June 1, 2006; 26(6): 1323 - 1329.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. Tedgui and Z. Mallat
Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways
Physiol Rev, April 1, 2006; 86(2): 515 - 581.
[Abstract] [Full Text] [PDF]

Home page
 QJMHome page
R. Ohashi, H. Mu, X. Wang, Q. Yao, and C. Chen
Reverse cholesterol transport and cholesterol efflux in atherosclerosis
QJM, December 1, 2005; 98(12): 845 - 856.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
A. Daugherty, N. R. Webb, D. L. Rateri, and V. L. King
Thematic review series: The Immune System and Atherogenesis. Cytokine regulation of macrophage functions in atherogenesis
J. Lipid Res., September 1, 2005; 46(9): 1812 - 1822.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
S. A. Irvine, P. Foka, S. A. Rogers, J. R. Mead, and D. P. Ramji
A critical role for the Sp1-binding sites in the transforming growth factor-{beta}-mediated inhibition of lipoprotein lipase gene expression in macrophages
Nucleic Acids Res., March 8, 2005; 33(5): 1423 - 1434.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
S. Suzuki, T. Nishimaki-Mogami, N. Tamehiro, K. Inoue, R. Arakawa, S. Abe-Dohmae, A. R. Tanaka, K. Ueda, and S. Yokoyama
Verapamil Increases the Apolipoprotein-Mediated Release of Cellular Cholesterol by Induction of ABCA1 Expression Via Liver X Receptor-Independent Mechanism
Arterioscler. Thromb. Vasc. Biol., March 1, 2004; 24(3): 519 - 525.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
N. van Royen, I. Hoefer, M. Bottinger, J. Hua, S. Grundmann, M. Voskuil, C. Bode, W. Schaper, I. Buschmann, and J.J. Piek
Local Monocyte Chemoattractant Protein-1 Therapy Increases Collateral Artery Formation in Apolipoprotein E-Deficient Mice but Induces Systemic Monocytic CD11b Expression, Neointimal Formation, and Plaque Progression
Circ. Res., February 7, 2003; 92(2): 218 - 225.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
R. Kaplan, X. Gan, J. G. Menke, S. D. Wright, and T.-Q. Cai
Bacterial lipopolysaccharide induces expression of ABCA1 but not ABCG1 via an LXR-independent pathway
J. Lipid Res., June 1, 2002; 43(6): 952 - 959.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
H. A. Feister, B. J. Auerbach, L. A. Cole, B. R. Krause, and S. K. Karathanasis
Identification of an IL-6 response element in the human LCAT promoter
J. Lipid Res., June 1, 2002; 43(6): 960 - 970.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
X.-Q. Wang, C. G. Panousis, M. L. Alfaro, G. F. Evans, and S. H. Zuckerman
Interferon-{gamma}-Mediated Downregulation of Cholesterol Efflux and ABC1 Expression Is by the Stat1 Pathway
Arterioscler. Thromb. Vasc. Biol., May 1, 2002; 22(5): e5 - 9.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
C. A. Argmann, C. H. Van Den Diepstraten, C. G. Sawyez, J. Y. Edwards, R. A. Hegele, B. M. Wolfe, and M. W. Huff
Transforming Growth Factor-{beta}1 Inhibits Macrophage Cholesteryl Ester Accumulation Induced by Native and Oxidized VLDL Remnants
Arterioscler. Thromb. Vasc. Biol., December 1, 2001; 21(12): 2011 - 2018.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2001 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement