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Journal of Lipid Research, Vol. 42, 995-997, June 2001
Copyright © 2001 by Lipid Research, Inc.

Rapid Communication

Isomerization increases the postprandial oxidation of linoleic acid but not {alpha}-linolenic acid in men

L. Bretillona, J. M. Chardignya, J. L. Sébédioa, J. P. Noëlb, C. M. Scrimgeourc, C. E. Ferniec, O. Loreaub, P. Gachond, and B. Beaufrèred
a Unité de Nutrition Lipidique, Institut National de la Recherche Agronomique, 21065 Dijon, France
b Service des Molécules Marquées, CEA-Saclay, 91191 Gif-sur-Yvette, France
c Scottish Crop Research Institute, Dundee DD2 5DA, Scotland
d Unité du Métabolisme Protéino Energétique, Université d'Auvergne, INRA, CRNH, 63001 Clermont-Ferrand, France

Correspondence to: J. M. Chardigny, To whom correspondence should be addressed., chardign{at}dijon.inra.fr (E-mail)

Human lipid intake contains various amounts of trans fatty acids. Refined vegetable and frying oils, rich in linoleic acid and/or {alpha}-linolenic acid, are the main dietary sources of trans-18:2 and trans-18:3 fatty acids. The aim of the present study was to compare the oxidation of linoleic acid, {alpha}-linolenic acid, and their major trans isomers in human volunteers. For that purpose, TG, each containing two molecules of [1-13C]linoleic acid, {alpha}-[1-13C]linolenic acid, [1-13C]-9cis,12trans-18:2, or [1-13C]-9cis,12cis,15trans-18:3, were synthesized. Eight healthy young men ingested labeled TG mixed with 30 g of olive oil. Total CO2 production and 13CO2 excretion were determined over 48 h. The pattern of oxidation was similar for the four fatty acids, with a peak at 8 h and a return to baseline at 24 h.

Cumulative oxidation over 8 h of linoleic acid, 9cis,12trans-18:2, {alpha}-linolenic acid, and 9cis,12cis,15trans-18:3 were, respectively, 14.0 ± 4.1%, 24.7 ± 6.7%, 23.6 ± 3.3%, and 23.4 ± 3.7% of the oral load, showing that isomerization increases the postprandial oxidation of linoleic acid but not {alpha}-linolenic acid in men. — Bretillon, L., J. M. Chardigny, J. L. Sébédio, J. P. Noël, C. M. Scrimgeour, C. E. Fernie, O. Loreau, P. Gachon, and B. Beaufrère. Isomerization increases the postprandial oxidation of linoleic acid but not {alpha}-linolenic acid in men. J. Lipid Res. 2001. 42: 995;–997.

Supplementary key words: human, oxidation, trans fatty acid


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