HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Riddell, D. R. Articles by Owen, J. S. Search for Related Content PubMed PubMed Citation Articles by Riddell, D. R. Articles by Owen, J. S. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 42, 998-1002, June 2001
Copyright © 2001 by Lipid Research, Inc.

Rapid Communication

Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane

Correspondence to: James S. Owen, j.owen{at}rfc.ucl.ac.uk (E-mail)

The LDL receptor (LDL-R) promotes the specific endocytosis and lysosomal delivery of extracellular lipoprotein ligands via clathrin-coated pits. It was widely assumed that other closely related members of the LDL-R gene family would have similar functions, but recent experimental evidence has revealed that one such protein, apolipoprotein E receptor 2 (apoER2), has a critical role as an "outside-in" signal transducer in the brain. ApoER2 signaling appears to require interaction between its cytoplasmic domain and adapter molecules such as Dab1, JIP 1 and JIP 2, and PSD-95. Many of the receptors for other signaling pathways affected by such adapter molecules are compartmentalized into specialized microdomains within the plasma membrane termed caveolae.

Here, we show that apoER2, but not LDL-R, is localized to caveolae, supporting the concept that its physiological role is in cell signaling, rather than in endocytosing ligands. — Riddell, D. R., X-M. Sun, A. K. Stannard, A. K. Soutar, and J. S. Owen. Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane. J. Lipid Res. 2001. 42: 998;–1002.

Supplementary key words: intracellular signaling, lipid raft, LDL-R family, LRP8

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				H. Mayer, S. Duit, C. Hauser, W. J. Schneider, and J. Nimpf Reconstitution of the Reelin Signaling Pathway in Fibroblasts Demonstrates that Dab1 Phosphorylation Is Independent of Receptor Localization in Lipid Rafts Mol. Cell. Biol., January 1, 2006; 26(1): 19 - 27. [Abstract] [Full Text] [PDF]

				T. Morimura, M. Hattori, M. Ogawa, and K. Mikoshiba Disabled1 Regulates the Intracellular Trafficking of Reelin Receptors J. Biol. Chem., April 29, 2005; 280(17): 16901 - 16908. [Abstract] [Full Text] [PDF]

				P. C. Stolt, Y. Chen, P. Liu, H. H. Bock, S. C. Blacklow, and J. Herz Phosphoinositide Binding by the Disabled-1 PTB Domain Is Necessary for Membrane Localization and Reelin Signal Transduction J. Biol. Chem., March 11, 2005; 280(10): 9671 - 9677. [Abstract] [Full Text] [PDF]

				H. Zhang, P. H. Links, J. K. Ngsee, K. Tran, Z. Cui, K. W. S. Ko, and Z. Yao Localization of Low Density Lipoprotein Receptor-related Protein 1 to Caveolae in 3T3-L1 Adipocytes in Response to Insulin Treatment J. Biol. Chem., January 16, 2004; 279(3): 2221 - 2230. [Abstract] [Full Text] [PDF]

				H. H. Bock, Y. Jossin, P. Liu, E. Forster, P. May, A. M. Goffinet, and J. Herz Phosphatidylinositol 3-Kinase Interacts with the Adaptor Protein Dab1 in Response to Reelin Signaling and Is Required for Normal Cortical Lamination J. Biol. Chem., October 3, 2003; 278(40): 38772 - 38779. [Abstract] [Full Text] [PDF]

				X.-M. Sun and A. K. Soutar The Transmembrane Domain and PXXP Motifs of ApoE Receptor 2 Exclude It from Carrying out Clathrin-mediated Endocytosis J. Biol. Chem., May 23, 2003; 278(22): 19926 - 19932. [Abstract] [Full Text] [PDF]

				B. Razani, S. E. Woodman, and M. P. Lisanti Caveolae: From Cell Biology to Animal Physiology Pharmacol. Rev., September 1, 2002; 54(3): 431 - 467. [Abstract] [Full Text] [PDF]

				A. K. Stannard, D. R. Riddell, S. M. Sacre, A. D. Tagalakis, C. Langer, A. von Eckardstein, P. Cullen, T. Athanasopoulos, G. Dickson, and J. S. Owen Cell-derived Apolipoprotein E (ApoE) Particles Inhibit Vascular Cell Adhesion Molecule-1 (VCAM-1) Expression in Human Endothelial Cells J. Biol. Chem., November 30, 2001; 276(49): 46011 - 46016. [Abstract] [Full Text] [PDF]