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Correspondence to:
Michael Dean, To whom correspondence should be addressed., dean{at}ncifcrf.gov (E-mail)
The transport of specific molecules across lipid membranes is an essential function of all living organisms and a large number of specific transporters have evolved to carry out this function. The largest transporter gene family is the ATP-binding cassette (ABC) transporter superfamily. These proteins translocate a wide variety of substrates including sugars, amino acids, metal ions, peptides, and proteins, and a large number of hydrophobic compounds and metabolites across extra- and intracellular membranes. ABC genes are essential for many processes in the cell, and mutations in these genes cause or contribute to several human genetic disorders including cystic fibrosis, neurological disease, retinal degeneration, cholesterol and bile transport defects, anemia, and drug response. Characterization of eukaryotic genomes has allowed the complete identification of all the ABC genes in the yeast Saccharomyces cerevisiae, Drosophila, and C. elegans genomes. To date, there are 48 characterized human ABC genes. The genes can be divided into seven distinct subfamilies, based on organization of domains and amino acid homology. Many ABC genes play a role in the maintenance of the lipid bilayer and in the transport of fatty acids and sterols within the body.
Here, we review the current knowledge of the human ABC genes, their role in inherited disease, and understanding of the topology of these genes within the membrane. — Dean, M., Y. Hamon, and G. Chimini. The human ATP-binding cassette (ABC) transporter superfamily. J. Lipid Res. 2001. 42: 1007;–1017.
Supplementary key words:
membrane transporters, evolution, lipid, genetic diseases, cholesterol
Copyright © 2001 by Lipid Research, Inc.
Thematic Review
The human ATP-binding cassette (ABC) transporter superfamily
Michael Deana,
Yannick Hamonb, and
Giovanna Chiminib
a Human Genetics Section, Laboratory of Genomic Diversity, National Cancer Institute-Frederick, Bldg. 560, Rm. 21-18, Frederick, MD 21702
b Centre d'Immunologie INSERM/CNRS de Marseille-Luminy, Marseille, 13288 Cedex 09, France
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