HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Banni, S. Articles by Ip, C. Search for Related Content PubMed PubMed Citation Articles by Banni, S. Articles by Ip, C. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 42, 1056-1061, July 2001
Copyright © 2001 by Lipid Research, Inc.

Original Article

Distribution of conjugated linoleic acid and metabolites in different lipid fractions in the rat liver

Correspondence to: Clement Ip, To whom correspondence should be addressed., clement.ip{at}roswellpark.org (E-mail)

Conjugated linoleic acid (CLA) is known to provide certain health benefits in experimental animal models. The major CLA isomer in food is c 9,t11-CLA. A primary objective of this study was to investigate the uptake of c 9,t11-CLA and its downstream metabolites into various lipid fractions in the liver of rats fed either a high or low CLA diet (containing 0.1 or 0.8 g CLA/100 g diet, respectively). As expected, the levels of all conjugated diene (CD) fatty acids (CD 18:2 + CD 18:3 + CD 20:3 + CD 20:4) were elevated about 8-fold in the high CLA diet group. However, there was no change in the distribution of CLA and CLA metabolites into various lipid fractions due to CLA intake. Unlike linoleic acid or -linolenic acid, which were distributed mainly in phospholipids, CD 18:2, CD 18:3, and CD 20:3 were incorporated primarily in neutral lipid. Furthermore, the incorporation of all nonconjugated unsaturated fatty acids was not perturbed by CLA. Regardless of the level of CLA in the diet, CD 20:4 was predominantly enriched in phosphatidylserine and phosphatidylinositol. In contrast, arachidonic acid was primarily enriched in phosphatidylcholine and less so in phosphatidylethanolamine.

The above findings may have potential implication regarding the role of CLA in modulating eicosanoid metabolism. — Banni, S., G. Carta, E. Angioni, E. Murru, P. Scanu, M. P. Melis, D. E. Bauman, S. M. Fischer, and C. Ip. Distribution of conjugated linoleic acid and metabolites in different lipid fractions in the rat liver. J. Lipid Res. 2001. 42: 1056;–1061.

Supplementary key words: conjugated linoleic acid, CLA metabolism, neutral lipid CLA, phospholipid CLA

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				E. Castaneda-Gutierrez, B. C. Benefield, M. J. de Veth, N. R. Santos, R. O. Gilbert, W. R. Butler, and D. E. Bauman Evaluation of the Mechanism of Action of Conjugated Linoleic Acid Isomers on Reproduction in Dairy Cows J Dairy Sci, September 1, 2007; 90(9): 4253 - 4264. [Abstract] [Full Text] [PDF]

				J. K. Kramer, C. Cruz-Hernandez, Z. Deng, J. Zhou, G. Jahreis, and M. E. Dugan Analysis of conjugated linoleic acid and trans 18:1 isomers in synthetic and animal products Am. J. Clinical Nutrition, June 1, 2004; 79(6): 1137S - 1145S. [Abstract] [Full Text] [PDF]

				R. S McLeod, A. M LeBlanc, M. A Langille, P. L Mitchell, and D. L Currie Conjugated linoleic acids, atherosclerosis, and hepatic very-low-density lipoprotein metabolism Am. J. Clinical Nutrition, June 1, 2004; 79(6): 1169S - 1174S. [Abstract] [Full Text] [PDF]

				J. M. Chardigny, E. Masson, J. P. Sergiel, M. Darbois, O. Loreau, J. P. Noel, and J.-L. Sebedio The Position of Rumenic Acid on Triacylglycerols Alters Its Bioavailability in Rats J. Nutr., December 1, 2003; 133(12): 4212 - 4214. [Abstract] [Full Text] [PDF]

				B. A. Corl, D. M. Barbano, D. E. Bauman, and C. Ip cis-9, trans-11 CLA Derived Endogenously from trans-11 18:1 Reduces Cancer Risk in Rats J. Nutr., September 1, 2003; 133(9): 2893 - 2900. [Abstract] [Full Text] [PDF]

				L. Demizieux, P. Degrace, J. Gresti, O. Loreau, J.-P. Noel, J.-M. Chardigny, J.-L. Sebedio, and P. Clouet Conjugated linoleic acid isomers in mitochondria: evidence for an alteration of fatty acid oxidation J. Lipid Res., December 1, 2002; 43(12): 2112 - 2122. [Abstract] [Full Text] [PDF]

				S. R. Demaree, C. D. Gilbert, H. J. Mersmann, and S. B. Smith Conjugated Linoleic Acid Differentially Modifies Fatty Acid Composition in Subcellular Fractions of Muscle and Adipose Tissue but Not Adiposity of Postweanling Pigs J. Nutr., November 1, 2002; 132(11): 3272 - 3279. [Abstract] [Full Text] [PDF]

				M. A. Belury Inhibition of Carcinogenesis by Conjugated Linoleic Acid: Potential Mechanisms of Action J. Nutr., October 1, 2002; 132(10): 2995 - 2998. [Abstract] [Full Text] [PDF]