Corn oil-induced decrease in arterial thrombosis tendency may be related to altered plasma vitamin K transport

L. J. Schurgers^a and C. Vermeer^a
^a Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, 6200 MD Maastricht, The Netherlands

Correspondence to: C. Vermeer, To whom correspondence should be addressed., c.vermeer{at}bioch.unimaas.nl (E-mail)

In this article we report the effects of low and high fat dietson the arterial thrombosis tendency in rats. The animal systemused was the aorta loop model, in which we compared the effectof saturated (hardened coconut oil, HCO) and unsaturated (sunflowerseed oil, SSO; corn oil, CO) fatty acids on the arterial thrombosistendency at high fat intake (50 energy%, 45 energy% of whichwas either HCO, SSO, or CO). Under these conditions both SSOand CO had a beneficial effect (relative to HCO) on the arterialthrombosis tendency. In a subsequent study we compared thesehigh fat diets with a low fat diet (5 energy%). As comparedwith the low fat diet, only CO significantly decreased the thrombosisrisk. Serum vitamin K and triglycerides had decreased substantiallyafter the CO diet, and to a much lesser extent after the SSOdiet.

It is concluded that corn oil may have a mildly anticoagulanteffect, the potential benefit of which is discussed. —Schurgers, L. J., and C. Vermeer. Corn oil-induced decreasein arterial thrombosis tendency may be related to altered plasmavitamin K transport. J. Lipid Res. 2001. 42: 1120;–1124.

Supplementary key words: PUFA, vessel wall, atherosclerosis, phylloquinone, aorta loop,nutritional oils, fatty acid

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Original Article

Corn oil-induced decrease in arterial thrombosis tendency may be related to altered plasma vitamin K transport