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Journal of Lipid Research, Vol. 42, 1298-1307, August 2001
Copyright © 2001 by Lipid Research, Inc.

Original Article

High prevalence of low HDL cholesterol concentrations and mixed hyperlipidemia in a Mexican nationwide survey

Correspondence to: Carlos A. Aguilar-Salinas, To whom correspondence should be addressed., caguilarsalinas{at}yahoo.com (E-mail)

The prevalence of lipid abnormalities revealed in a survey done in 417 Mexican cities is described. Information was obtained on 15,607 subjects, aged 20 to 69 years. In this report, only samples obtained after a 9- to 12-h fast were included (2,256 cases: 953 men and 1,303 women). The population is representative of Mexican urban adults. Mean lipid concentrations were: cholesterol, 4.80 mmol/l; triglycerides, 2.39 mmol/l; HDL cholesterol, 1.00 mmol/l; and LDL cholesterol, 3.06 mmol/l. The most prevalent abnormality was HDL cholesterol below 0.9 mmol/l (46.2% for men and 28.7% for women). Hypertriglyceridemia (>2.26 mmol/l) was the second most prevalent abnormality (24.3%). Severe hypertriglyceridemia (>11.2 mmol/l) was observed in 0.42% of the population. Increased LDL cholesterol (4.21 mmol/l) was observed in 11.2% of the sample. Half of the hypertriglyceridemic subjects had a mixed dyslipidemia or low HDL cholesterol. More than 50% of the low HDL cholesterol cases were not related to hypertriglyceridemia. Insulin resistance was found in 59% of them.

In conclusion, the prevalence of hypoalphalipoproteinemia and other forms of dyslipidemia in Mexican adults is very high and it is among the highest previously reported worldwide. — Aguilar-Salinas, C. A., G. Olaiz, V. Valles, J. M. Ríos Torres, F. J. Gómez Pérez, J. A. Rull, R. Rojas, A. Franco, and J. Sepulveda. High prevalence of low HDL cholesterol concentrations and mixed hyperlipidemia in a Mexican nationwide survey. J. Lipid Res. 2001. 42: 1298;–1307.

Supplementary key words: diabetes, obesity, hypertension, cholesterol, Mexico, insulin resistance, hypertriglyceridemia

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