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Correspondence to:
Silvia Santamarina-Fojo, To whom correspondence should be addressed., silvia{at}mdb.nhlbi.nih.gov (E-mail)
The discovery of the role of the ATP-binding cassette transporter A1 (ABCA1) in mediating apolipoprotein A-I-mediated efflux has led to a dramatic increase in our knowledge of the molecular mechanisms involved in cholesterol efflux and cellular metabolism. In this review, we discuss several aspects of ABCA1 regulation including i) transcriptional regulation, ii) substrate specificity and availability, iii) accessory proteins, iv) acceptor specificity and availability, and v) protein trafficking. The majority of studies of ABCA1 regulation to date have focused on the identification of promoter elements that determine ABCA1 gene transcription. Here we also review the potential functional role of ABCA1 in reverse cholesterol transport.
Given the key role that ABCA1 plays in cholesterol homeostasis, it is likely that there are multiple mechanisms for controlling the overall transporter activity of ABCA1. — Santamarina-Fojo, S., A. T. Remaley, E. B. Neufeld, and H. B. Brewer, Jr. Regulation and intracellular trafficking of the ABCA1 transporter. J. Lipid Res. 2001. 42: 1339;–1345.
Supplementary key words:
Tangier disease, HDL, ABC transporters
Copyright © 2001 by Lipid Research, Inc.
Thematic Review Article
Regulation and intracellular trafficking of the ABCA1 transporter
Silvia Santamarina-Fojoa,
Alan T. Remaleya,
Edward B. Neufelda, and
H. Bryan Brewer, Jr.a
a Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892
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