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Correspondence to:
Peter A. Edwards, at Department of Biological Chemistry, CHS 33-257, UCLA School of Medicine, Los Angeles, CA 90095-1769., pedwards{at}mednet.ucla.edu (E-mail)
During the last three years there have been a plethora of publications on the liver X-activated receptors (LXR
In this review we emphasize i) the role of LXR in controlling many aspects of cholesterol and fatty acid metabolism, ii) the expanded role of FXR in regulating genes that control not only bile acid metabolism but also lipoprotein metabolism, and iii) the regulation of bile acid transport/metabolism in response to bile acid-activated PXR. — Edwards, P. A., H. R. Kast, and A. M. Anisfeld. BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. J. Lipid Res. 2002. 43: 2–12.
Supplementary key words:
bile acids, oxysterols, Tangier disease, sitosterolemia, ABC transporters, lipoproteins, farnesoid X-activated receptor, liver X-activated receptor, pregnane X receptor
Copyright © 2002 by Lipid Research, Inc.
Thematic Review
BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis
Peter A. Edwardsa,b,
Heidi R. Kasta, and
Andrew M. Anisfelda
a Departments of Biological Chemistry and Medicine, University of California, Los Angeles, CA 90095
b Molecular Biology Institute, University of California, Los Angeles, CA 90095
, NR1H3, and LXRß, NR1H2), the farnesoid X-activated receptor (FXR, NR1H4), and the pregnane X receptor (PXR, NR1I2) and the role these nuclear receptors play in controlling cholesterol, bile acid, lipoprotein and drug metabolism. The current interest in these nuclear receptors is high, in part, because they appear to be promising therapeutic targets for new drugs that have the potential to control lipid homeostasis. 
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