|
 |
|
|||||||
|
|||||||||
Journal of Lipid Research, Vol. 43, 1585-1594, October 2002
Copyright © 2002 by Lipid Research, Inc.
Thematic Review |
Hormone-sensitive lipase
: control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis
a Division of Endocrinology, Department of Medicine, Stanford University, Stanford, CA
b Veterans Administration Palo Alto Health Care System, Palo Alto, CA
1 To whom correspondence should be addressed. e-mail: fbk{at}stanford.edu
Hormone-sensitive lipase (HSL) is an intracellular neutral lipase that is capable of hydrolyzing triacylglycerols, diacylglycerols, monoacylglycerols, and cholesteryl esters, as well as other lipid and water soluble substrates. HSL activity is regulated post-translationally by phosphorylation and also by pretranslational mechanisms. The enzyme is highly expressed in adipose tissue and steroidogenic tissues, with lower amounts expressed in cardiac and skeletal muscle, macrophages, and islets. Studies of the structure of HSL have identified several amino acids and regions of the molecule that are critical for enzymatic activity and regulation of HSL. This has led to important insights into its function, including the interaction of HSL with other intracellular proteins, such as adipocyte lipid binding protein. Accumulating evidence has defined important functions for HSL in normal physiology, affecting adipocyte lipolysis, steroidogenesis, spermatogenesis, and perhaps insulin secretion and insulin action; however, direct links between abnormal expression or genetic variations of HSL and human disorders, such as obesity, insulin resistance, type 2 diabetes, and hyperlipidemia, await further clarification.
The published reports examining the regulation, and function of HSL in normal physiology and disease are reviewed in this paper.
Abbreviations: ALBP, adipocyte lipid-binding protein; ERK, extracellular signal-regulated kinase; FFA, free fatty acids; HSL, hormone-sensitive lipase; PKA, cyclic AMP dependent protein kinase
Supplementary key words lipolysis • free fatty acids • adipose • adrenal • macrophage • testis • islet
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  P. R. Manna, M. T. Dyson, and D. M. Stocco Regulation of the steroidogenic acute regulatory protein gene expression: present and future perspectives Mol. Hum. Reprod., June 1, 2009; 15(6): 321 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Zhang, M.-S. Yoon, and J. Chen Amino acid-sensing mTOR signaling is involved in modulation of lipolysis by chronic insulin treatment in adipocytes Am J Physiol Endocrinol Metab, April 1, 2009; 296(4): E862 - E868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhao, A. Peter, J. Fritsche, M. Elcnerova, A. Fritsche, H.-U. Haring, E. D. Schleicher, G. Xu, and R. Lehmann Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at? Am J Physiol Endocrinol Metab, February 1, 2009; 296(2): E384 - E393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Zechner, P. C. Kienesberger, G. Haemmerle, R. Zimmermann, and A. Lass Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores J. Lipid Res., January 1, 2009; 50(1): 3 - 21. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tejerina, A. De Pauw, S. Vankoningsloo, A. Houbion, P. Renard, F. De Longueville, M. Raes, and T. Arnould Mild mitochondrial uncoupling induces 3T3-L1 adipocyte de-differentiation by a PPAR{gamma}-independent mechanism, whereas TNF{alpha}-induced de-differentiation is PPAR{gamma} dependent J. Cell Sci., January 1, 2009; 122(1): 145 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-A. Cornier, D. Dabelea, T. L. Hernandez, R. C. Lindstrom, A. J. Steig, N. R. Stob, R. E. Van Pelt, H. Wang, and R. H. Eckel The Metabolic Syndrome Endocr. Rev., December 1, 2008; 29(7): 777 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Okazaki, M. Igarashi, M. Nishi, M. Sekiya, M. Tajima, S. Takase, M. Takanashi, K. Ohta, Y. Tamura, S. Okazaki, et al. Identification of Neutral Cholesterol Ester Hydrolase, a Key Enzyme Removing Cholesterol from Macrophages J. Biol. Chem., November 28, 2008; 283(48): 33357 - 33364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sekiya, J.-i. Osuga, N. Yahagi, H. Okazaki, Y. Tamura, M. Igarashi, S. Takase, K. Harada, S. Okazaki, Y. Iizuka, et al. Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis J. Lipid Res., August 1, 2008; 49(8): 1829 - 1838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ueno, J. Suzuki, Y. Zenimaru, S. Takahashi, T. Koizumi, S. Noriki, O. Yamaguchi, K. Otsu, W.-J. Shen, F. B. Kraemer, et al. Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice Am J Physiol Endocrinol Metab, June 1, 2008; 294(6): E1109 - E1118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. P. Mottillo, X. J. Shen, and J. G. Granneman Role of hormone-sensitive lipase in beta-adrenergic remodeling of white adipose tissue Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1188 - E1197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Izem and R. E. Morton Possible Role for Intracellular Cholesteryl Ester Transfer Protein in Adipocyte Lipid Metabolism and Storage J. Biol. Chem., July 27, 2007; 282(30): 21856 - 21865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Jaworski, E. Sarkadi-Nagy, R. E. Duncan, M. Ahmadian, and H. S. Sul Regulation of Triglyceride Metabolism. * IV. Hormonal regulation of lipolysis in adipose tissue Am J Physiol Gastrointest Liver Physiol, July 1, 2007; 293(1): G1 - G4. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Simon and B. F. Cravatt Endocannabinoid Biosynthesis Proceeding through Glycerophospho-N-acyl Ethanolamine and a Role for {alpha}/beta-Hydrolase 4 in This Pathway J. Biol. Chem., September 8, 2006; 281(36): 26465 - 26472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Okazaki, M. Igarashi, M. Nishi, M. Tajima, M. Sekiya, S. Okazaki, N. Yahagi, K. Ohashi, K. Tsukamoto, M. Amemiya-Kudo, et al. Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis. Diabetes, July 1, 2006; 55(7): 2091 - 2097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Marcinkiewicz, D. Gauthier, A. Garcia, and D. L. Brasaemle The Phosphorylation of Serine 492 of Perilipin A Directs Lipid Droplet Fragmentation and Dispersion J. Biol. Chem., April 28, 2006; 281(17): 11901 - 11909. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Deng, S. Shan, P.-P. Li, Z.-F. Shen, X.-P. Lu, J. Cheng, and Z.-Q. Ning Peroxisome Proliferator-Activated Receptor-{gamma} Transcriptionally Up-Regulates Hormone-Sensitive Lipase via the Involvement of Specificity Protein-1 Endocrinology, February 1, 2006; 147(2): 875 - 884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Kershaw, J. K. Hamm, L. A.W. Verhagen, O. Peroni, M. Katic, and J. S. Flier Adipose Triglyceride Lipase: Function, Regulation by Insulin, and Comparison With Adiponutrin Diabetes, January 1, 2006; 55(1): 148 - 157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Hu, J. T. Deeney, C. J. Nolan, M.-L. Peyot, A. Ao, A. M. Richard, E. Luc, N. J. Faergeman, J. Knudsen, W. Guo, et al. Regulation of lipolytic activity by long-chain acyl-coenzyme A in islets and adipocytes Am J Physiol Endocrinol Metab, December 1, 2005; 289(6): E1085 - E1092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Birner-Gruenberger, H. Susani-Etzerodt, M. Waldhuber, G. Riesenhuber, H. Schmidinger, G. Rechberger, M. Kollroser, J. G. Strauss, A. Lass, R. Zimmermann, et al. The Lipolytic Proteome of Mouse Adipose Tissue Mol. Cell. Proteomics, November 1, 2005; 4(11): 1710 - 1717. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Rozec, S. Serpillon, G. Toumaniantz, C. Seze, Y. Rautureau, O. Baron, J. Noireaud, and C. Gauthier Characterization of Beta3-Adrenoceptors in Human Internal Mammary Artery and Putative Involvement in Coronary Artery Bypass Management J. Am. Coll. Cardiol., July 19, 2005; 46(2): 351 - 359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Patel, J. L. Soulages, B. Hariharasundaram, and E. L. Arrese Activation of the Lipid Droplet Controls the Rate of Lipolysis of Triglycerides in the Insect Fat Body J. Biol. Chem., June 17, 2005; 280(24): 22624 - 22631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ben Ali, F. Carriere, R. Verger, S. Petry, G. Muller, and A. Abousalham Continuous monitoring of cholesterol oleate hydrolysis by hormone-sensitive lipase and other cholesterol esterases J. Lipid Res., May 1, 2005; 46(5): 994 - 1000. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Cabassi, P. Coghi, P. Govoni, E. Barouhiel, E. Speroni, S. Cavazzini, A. M. Cantoni, R. Scandroglio, and E. Fiaccadori Sympathetic Modulation by Carvedilol and Losartan Reduces Angiotensin II-Mediated Lipolysis in Subcutaneous and Visceral Fat J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2888 - 2897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Petry, Y. B. Ali, H. Chahinian, H. Jordan, H. Kleine, G. Muller, F. Carriere, and A. Abousalham Sensitive assay for hormone-sensitive lipase using NBD-labeled monoacylglycerol to detect low activities in rat adipocytes J. Lipid Res., March 1, 2005; 46(3): 603 - 614. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Smith, M. A. Sanders, B. R. Thompson, C. Londos, F. B. Kraemer, and D. A. Bernlohr Physical Association between the Adipocyte Fatty Acid-binding Protein and Hormone-sensitive Lipase: A FLUORESCENCE RESONANCE ENERGY TRANSFER ANALYSIS J. Biol. Chem., December 10, 2004; 279(50): 52399 - 52405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Jenkins, D. J. Mancuso, W. Yan, H. F. Sims, B. Gibson, and R. W. Gross Identification, Cloning, Expression, and Purification of Three Novel Human Calcium-independent Phospholipase A2 Family Members Possessing Triacylglycerol Lipase and Acylglycerol Transacylase Activities J. Biol. Chem., November 19, 2004; 279(47): 48968 - 48975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Vallet-Erdtmann, G. Tavernier, J. A. Contreras, A. Mairal, C. Rieu, A.-M. Touzalin, C. Holm, B. Jegou, and D. Langin The Testicular Form of Hormone-sensitive Lipase HSLtes Confers Rescue of Male Infertility in HSL-deficient Mice J. Biol. Chem., October 8, 2004; 279(41): 42875 - 42880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Bastie, T. Hajri, V. A. Drover, P. A. Grimaldi, and N. A. Abumrad CD36 in Myocytes Channels Fatty Acids to a Lipase-Accessible Triglyceride Pool That Is Related to Cell Lipid and Insulin Responsiveness Diabetes, September 1, 2004; 53(9): 2209 - 2216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fortier, S. P. Wang, P. Mauriege, M. Semache, L. Mfuma, H. Li, E. Levy, D. Richard, and G. A. Mitchell Hormone-sensitive lipase-independent adipocyte lipolysis during {beta}-adrenergic stimulation, fasting, and dietary fat loading Am J Physiol Endocrinol Metab, August 1, 2004; 287(2): E282 - E288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-L. Peyot, C. J. Nolan, K. Soni, E. Joly, R. Lussier, B. E. Corkey, S. P. Wang, G. A. Mitchell, and M. Prentki Hormone-Sensitive Lipase Has a Role in Lipid Signaling for Insulin Secretion but Is Nonessential for the Incretin Action of Glucagon-Like Peptide 1 Diabetes, July 1, 2004; 53(7): 1733 - 1742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sekiya, J.-i. Osuga, H. Okazaki, N. Yahagi, K. Harada, W.-J. Shen, Y. Tamura, S. Tomita, Y. Iizuka, K. Ohashi, et al. Absence of Hormone-sensitive Lipase Inhibits Obesity and Adipogenesis in Lepob/ob Mice J. Biol. Chem., April 9, 2004; 279(15): 15084 - 15090. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Wagner, D. Kratky, G. Haemmerle, A. Hrzenjak, G. M. Kostner, E. Steyrer, and R. Zechner Defective uptake of triglyceride-associated fatty acids in adipose tissue causes the SREBP-1c-mediated induction of lipogenesis J. Lipid Res., February 1, 2004; 45(2): 356 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Harada, W.-J. Shen, S. Patel, V. Natu, J. Wang, J.-i. Osuga, S. Ishibashi, and F. B. Kraemer Resistance to high-fat diet-induced obesity and altered expression of adipose-specific genes in HSL-deficient mice Am J Physiol Endocrinol Metab, December 1, 2003; 285(6): E1182 - E1195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Jenkins-Kruchten, A. Bennaars-Eiden, J. R. Ross, W.-J. Shen, F. B. Kraemer, and D. A. Bernlohr Fatty Acid-binding Protein-Hormone-sensitive Lipase Interaction: FATTY ACID DEPENDENCE ON BINDING J. Biol. Chem., November 28, 2003; 278(48): 47636 - 47643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zimmermann, G. Haemmerle, E. M. Wagner, J. G. Strauss, D. Kratky, and R. Zechner Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipase-deficient white adipose tissue J. Lipid Res., November 1, 2003; 44(11): 2089 - 2099. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Nan, J.-X. Cheng, and X. S. Xie Vibrational imaging of lipid droplets in live fibroblast cells with coherent anti-Stokes Raman scattering microscopy J. Lipid Res., November 1, 2003; 44(11): 2202 - 2208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-J. Shen, S. Patel, V. Natu, R. Hong, J. Wang, S. Azhar, and F. B. Kraemer Interaction of Hormone-sensitive Lipase with Steroidogeneic Acute Regulatory Protein: FACILITATION OF CHOLESTEROL TRANSFER IN ADRENAL J. Biol. Chem., October 31, 2003; 278(44): 43870 - 43876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Schmitt, M. Fluck, J. Decombaz, R. Kreis, C. Boesch, M. Wittwer, F. Graber, M. Vogt, H. Howald, and H. Hoppeler Transcriptional adaptations of lipid metabolism in tibialis anterior muscle of endurance-trained athletes Physiol Genomics, October 17, 2003; 15(2): 148 - 157. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |