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Journal of Lipid Research, Vol. 43, 1743-1749, October 2002
Copyright © 2002 by Lipid Research, Inc.

Leptin levels in rat offspring are modified by the ratio of linoleic to -linolenic acid in the maternal diet

Marina Korotkova^1,*, Britt Gabrielsson, Malin Lönn, Lars-Åke Hanson and Brigitta Strandvik^*

^* Departments of Pediatrics, Department of Internal Medicine, Göteborg University, Sweden
Clinical Immunology, Department of Internal Medicine, Göteborg University, Sweden
Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Göteborg University, Sweden

¹ To whom correspondence should be addressed. e-mail: marina.korotkova{at}vgregion.se

The supply of polyunsaturated fatty acids (PUFA) is important for optimal fetal and postnatal development. We have previously shown that leptin levels in suckling rats are reduced by maternal PUFA deficiency. In the present study, we evaluated the effect of maternal dietary intake of (n-3) and (n-6) PUFA on the leptin content in rat milk and serum leptin levels in suckling pups. For the last 10 days of gestation and throughout lactation, the rats were fed an isocaloric diet containing 7% linseed oil (n-3 diet), sunflower oil (n-6 diet), or soybean oil (n-6/n-3 diet). Body weight, body length, inguinal fat pad weight, and adipocyte size of the pups receiving the n-3 diet were significantly lower during the whole suckling period compared with n-6/n-3 fed pups. Body and fat pad weights of the n-6 fed pups were in between the other two groups at week one, but not different from the n-6/n-3 group at week 3. Feeding dams the n-3 diet resulted in decreased serum leptin levels in the suckling pups compared with pups in the n-6/n-3 group. The mean serum leptin levels of the n-6 pups were between the other two groups but not different from either group. There were no differences in the milk leptin content between the groups.

These results show that the balance between the n-6 and n-3 PUFA in the maternal diet rather than amount of n-6 or n-3 PUFA per se could be important for adipose tissue growth and for maintaining adequate serum leptin levels in the offspring.

Abbreviations: FA, fatty acids; PUFA, polyunsaturated fatty acids; MUFA, monounsaturated fatty acids; SFA, saturated fatty acids; USI, unsaturation index

Supplementary key words lactation • leptin mRNA • arachidonic acid • diet • adipose tissue • and perinatal period

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