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Journal of Lipid Research, Vol. 43, 1770-1772, November 2002
Copyright © 2002 by Lipid Research, Inc.
Rapid Communication |
Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
* Biomedical Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan
Pharmacology and Molecular Biology Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan
2 To whom correspondence should be addressed. e-mail: furuka{at}shina.sankyo.co.jp
ABSTRACT
Studies with KK/San, obese and diabetic model mice having a unique hypotriglyceridemia phenotype, revealed that angiopoietin-like protein 3 (ANGPTL3) regulates lipid metabolism in mice. To determine the lipid-modulating role of other ANGPTLs, we focused on ANGPTL4, which overall shows a significant similarity to ANGPTL3. Surprisingly, an intravenous injection of the ANGPTL4 protein in KK/San mice rapidly increased the circulating plasma lipid levels at a higher rate than ANGPTL3 protein.
Furthermore, the ANGPTL4 protein inhibited the lipoprotein lipase activity in vitro.
Supplementary key words KK/San • intravenous injection • plasma triglyceride
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