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Originally published In Press as doi:10.1194/jlr.R200015-JLR200 on October 1, 2002
Papers In Press, published online ahead of print December 1, 2002
J. Lipid Res., doi:10.1194/jlr.R200015-JLR200
Journal of Lipid Research, Vol. 43, 1997-2006, December 2002
Copyright © 2002 by Lipid Research, Inc.
Lipoprotein lipase
:
genetics, lipid uptake, and regulation
Martin Merkel*,
Robert H. Eckel and
Ira J. Goldberg1,
* Department of Medicine, University of Hamburg, Hamburg, Germany
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY
1 To whom correspondence should be addressed. e-mail: IJG3{at}columbia.edu
Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and their effects on plasma lipids and coronary heart disease are discussed. 2) LPL actions in the nervous system, liver, and heart: the discussion focuses on LPL and tissue lipid uptake.
3) LPL gene regulation: the LPL promoter and its regulatory elements are described.
Abbreviations: CAD, coronary artery disease; FA, fatty acid; LPL, lipoprotein lipase; TG, triglyceride Supplementary key words triglycerides chylomicronemia atherosclerosis lipoproteins lipid metabolism mutations human promoter review

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|
 |
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|
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|
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|
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|
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27(11):
2420 - 2427.
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[Full Text]
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|
 |
|

|
 |

|
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282(12):
8557 - 8567.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Yokoyama, T. Seo, T. Park, H. Yagyu, Y. Hu, N. H. Son, A. S. Augustus, R. K. Vikramadithyan, R. Ramakrishnan, L. K. Pulawa, et al.
Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscle
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March 1, 2007;
48(3):
646 - 655.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. Qi and B. Rodrigues
Glucocorticoids produce whole body insulin resistance with changes in cardiac metabolism
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March 1, 2007;
292(3):
E654 - E667.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
B. Loeffler, J. Heeren, M. Blaeser, H. Radner, D. Kayser, B. Aydin, and M. Merkel
Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor
J. Lipid Res.,
February 1, 2007;
48(2):
288 - 298.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G.-Q. Chang, O. Karatayev, R. Ahsan, V. Gaysinskaya, Z. Marwil, and S. F. Leibowitz
Dietary fat stimulates endogenous enkephalin and dynorphin in the paraventricular nucleus: role of circulating triglycerides
Am J Physiol Endocrinol Metab,
February 1, 2007;
292(2):
E561 - E570.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. Backhed, J. K. Manchester, C. F. Semenkovich, and J. I. Gordon
From the Cover: Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
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January 16, 2007;
104(3):
979 - 984.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
V. Sukonina, A. Lookene, T. Olivecrona, and G. Olivecrona
Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue
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November 14, 2006;
103(46):
17450 - 17455.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Ranganathan, R. Unal, I. Pokrovskaya, A. Yao-Borengasser, B. Phanavanh, B. Lecka-Czernik, N. Rasouli, and P. A. Kern
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J. Lipid Res.,
November 1, 2006;
47(11):
2444 - 2450.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
F. G. Schaap, M. C. Nierman, J. F. P. Berbee, H. Hattori, P. J. Talmud, S. F. C. Vaessen, P. C. N. Rensen, R. A. F. M. Chamuleau, J. A. Kuivenhoven, and A. K. Groen
Evidence for a complex relationship between apoA-V and apoC-III in patients with severe hypertriglyceridemia
J. Lipid Res.,
October 1, 2006;
47(10):
2333 - 2339.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. An and B. Rodrigues
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Am J Physiol Heart Circ Physiol,
October 1, 2006;
291(4):
H1489 - H1506.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. L.E. Klos, C. F. Sing, E. Boerwinkle, S. C. Hamon, T. J. Rea, A. Clark, M. Fornage, and J. E. Hixson
Consistent Effects of Genes Involved in Reverse Cholesterol Transport on Plasma Lipid and Apolipoprotein Levels in CARDIA Participants
Arterioscler. Thromb. Vasc. Biol.,
August 1, 2006;
26(8):
1828 - 1836.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Noer, A. L. Sorensen, A. C. Boquest, and P. Collas
Stable CpG Hypomethylation of Adipogenic Promoters in Freshly Isolated, Cultured, and Differentiated Mesenchymal Stem Cells from Adipose Tissue
Mol. Biol. Cell,
August 1, 2006;
17(8):
3543 - 3556.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. Katzenellenbogen, O. Pappo, H. Barash, N. Klopstock, L. Mizrahi, D. Olam, J. Jacob-Hirsch, N. Amariglio, G. Rechavi, L. A. Mitchell, et al.
Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the mdr2-knockout mice.
Cancer Res.,
April 15, 2006;
66(8):
4001 - 4010.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
H. H. Wittrup, R. V. Andersen, A. Tybjaerg-Hansen, G. B. Jensen, and B. G. Nordestgaard
Combined Analysis of Six Lipoprotein Lipase Genetic Variants on Triglycerides, High-Density Lipoprotein, and Ischemic Heart Disease: Cross-Sectional, Prospective, and Case-Control Studies from the Copenhagen City Heart Study
J. Clin. Endocrinol. Metab.,
April 1, 2006;
91(4):
1438 - 1445.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
J. Heeren, U. Beisiegel, and T. Grewal
Apolipoprotein E Recycling: Implications for Dyslipidemia and Atherosclerosis
Arterioscler. Thromb. Vasc. Biol.,
March 1, 2006;
26(3):
442 - 448.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
S.-i. Oka, H. Masutani, W. Liu, H. Horita, D. Wang, S. Kizaka-Kondoh, and J. Yodoi
Thioredoxin-Binding Protein-2-Like Inducible Membrane Protein Is a Novel Vitamin D3 and Peroxisome Proliferator-Activated Receptor (PPAR){gamma} Ligand Target Protein that Regulates PPAR{gamma} Signaling
Endocrinology,
February 1, 2006;
147(2):
733 - 743.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Pulinilkunnil and B. Rodrigues
Cardiac lipoprotein lipase: Metabolic basis for diabetic heart disease
Cardiovasc Res,
February 1, 2006;
69(2):
329 - 340.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Koster, Y. B. Chao, M. Mosior, A. Ford, P. A. Gonzalez-DeWhitt, J. E. Hale, D. Li, Y. Qiu, C. C. Fraser, D. D. Yang, et al.
Transgenic Angiopoietin-Like (Angptl)4 Overexpression and Targeted Disruption of Angptl4 and Angptl3: Regulation of Triglyceride Metabolism
Endocrinology,
November 1, 2005;
146(11):
4943 - 4950.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. M. Mutch, W. Wahli, and G. Williamson
Nutrigenomics and nutrigenetics: the emerging faces of nutrition
FASEB J,
October 1, 2005;
19(12):
1602 - 1616.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
W. C. Stanley, F. A. Recchia, and G. D. Lopaschuk
Myocardial Substrate Metabolism in the Normal and Failing Heart
Physiol Rev,
July 1, 2005;
85(3):
1093 - 1129.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. F. Lewis and D. J. Rader
New Insights Into the Regulation of HDL Metabolism and Reverse Cholesterol Transport
Circ. Res.,
June 24, 2005;
96(12):
1221 - 1232.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
D. An, G. Kewalramani, D. Qi, T. Pulinilkunnil, S. Ghosh, A. Abrahani, R. Wambolt, M. Allard, S. M. Innis, and B. Rodrigues
{beta}-Agonist stimulation produces changes in cardiac AMPK and coronary lumen LPL only during increased workload
Am J Physiol Endocrinol Metab,
June 1, 2005;
288(6):
E1120 - E1127.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G D Kolovou, K K Anagnostopoulou, and D V Cokkinos
Pathophysiology of dyslipidaemia in the metabolic syndrome
Postgrad. Med. J.,
June 1, 2005;
81(956):
358 - 366.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
T. Pulinilkunnil, D. An, S. Ghosh, D. Qi, G. Kewalramani, G. Yuen, N. Virk, A. Abrahani, and B. Rodrigues
Lysophosphatidic acid-mediated augmentation of cardiomyocyte lipoprotein lipase involves actin cytoskeleton reorganization
Am J Physiol Heart Circ Physiol,
June 1, 2005;
288(6):
H2802 - H2810.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. L. Pappan, Z. Pan, G. Kwon, C. A. Marshall, T. Coleman, I. J. Goldberg, M. L. McDaniel, and C. F. Semenkovich
Pancreatic {beta}-Cell Lipoprotein Lipase Independently Regulates Islet Glucose Metabolism and Normal Insulin Secretion
J. Biol. Chem.,
March 11, 2005;
280(10):
9023 - 9029.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
X. Yu, S. C. Burgess, H. Ge, K. K. Wong, R. H. Nassem, D. J. Garry, A. D. Sherry, C. R. Malloy, J. P. Berger, and C. Li
Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart
PNAS,
February 1, 2005;
102(5):
1767 - 1772.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
X. Wang and B. Paigen
Genetics of Variation in HDL Cholesterol in Humans and Mice
Circ. Res.,
January 7, 2005;
96(1):
27 - 42.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
A. Lookene, L. Zhang, M. Hultin, and G. Olivecrona
Rapid Subunit Exchange in Dimeric Lipoprotein Lipase and Properties of the Inactive Monomer
J. Biol. Chem.,
November 26, 2004;
279(48):
49964 - 49972.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
K. C-W. Yu, C. David, S. Kadambi, A. Stahl, K.-I. Hirata, T. Ishida, T. Quertermous, A. D. Cooper, and S. Y. Choi
Endothelial lipase is synthesized by hepatic and aorta endothelial cells and its expression is altered in apoE-deficient mice
J. Lipid Res.,
September 1, 2004;
45(9):
1614 - 1623.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
N. Ishimori, R. Li, P. M. Kelmenson, R. Korstanje, K. A. Walsh, G. A. Churchill, K. Forsman-Semb, and B. Paigen
Quantitative trait loci that determine plasma lipids and obesity in C57BL/6J and 129S1/SvImJ inbred mice
J. Lipid Res.,
September 1, 2004;
45(9):
1624 - 1632.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G.-Q. Chang, O. Karatayev, Z. Davydova, and S. F. Leibowitz
Circulating Triglycerides Impact on Orexigenic Peptides and Neuronal Activity in Hypothalamus
Endocrinology,
August 1, 2004;
145(8):
3904 - 3912.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
Y.-G. Niu, D. Hauton, and R. D. Evans
Utilization of triacylglycerol-rich lipoproteins by the working rat heart: routes of uptake and metabolic fates
J. Physiol.,
July 1, 2004;
558(1):
225 - 237.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
G. Wu, P. Brouckaert, and T. Olivecrona
Rapid downregulation of adipose tissue lipoprotein lipase activity on food deprivation: evidence that TNF-{alpha} is involved
Am J Physiol Endocrinol Metab,
May 1, 2004;
286(5):
E711 - E717.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
M. A. Lyons, H. Wittenburg, R. Li, K. A. Walsh, R. Korstanje, G. A. Churchill, M. C. Carey, and B. Paigen
Quantitative trait loci that determine lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and CAST/Ei inbred mice
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March 12, 2004;
17(1):
60 - 68.
[Abstract]
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|
 |
|

|
 |

|
 |
 
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7636 - 7642.
[Abstract]
[Full Text]
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|
 |
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|
 |

|
 |
 
E. M. Wagner, D. Kratky, G. Haemmerle, A. Hrzenjak, G. M. Kostner, E. Steyrer, and R. Zechner
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February 1, 2004;
45(2):
356 - 365.
[Abstract]
[Full Text]
[PDF]
|
 |
|

|
 |

|
 |
 
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J. Biol. Chem.,
January 2, 2004;
279(1):
238 - 244.
[Abstract]
[Full Text]
[PDF]
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O. Ziouzenkova, L. Asatryan, D. Sahady, G. Orasanu, S. Perrey, B. Cutak, T. Hassell, T. E. Akiyama, J. P. Berger, A. Sevanian, et al.
Dual Roles for Lipolysis and Oxidation in Peroxisome Proliferation-Activator Receptor Responses to Electronegative Low Density Lipoprotein
J. Biol. Chem.,
October 10, 2003;
278(41):
39874 - 39881.
[Abstract]
[Full Text]
[PDF]
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T. Pulinilkunnil, D. Qi, S. Ghosh, C. Cheung, P. Yip, J. Varghese, A. Abrahani, R. Brownsey, and B. Rodrigues
Circulating triglyceride lipolysis facilitates lipoprotein lipase translocation from cardiomyocyte to myocardial endothelial lining
Cardiovasc Res,
September 1, 2003;
59(3):
788 - 797.
[Abstract]
[Full Text]
[PDF]
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G. Camejo
Hydrolytic Enzymes Released From Resident Macrophages and Located in the Intima Extracellular Matrix as Agents That Modify Retained Apolipoprotein B Lipoproteins
Arterioscler. Thromb. Vasc. Biol.,
August 1, 2003;
23(8):
1312 - 1313.
[Full Text]
[PDF]
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Copyright © 2002 by the American Society for Biochemistry and Molecular Biology.
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