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Papers In Press, published online ahead of print December 1, 2002
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Thematic Review |
* Department of Medicine, University of Hamburg, Hamburg, Germany
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY
1 To whom correspondence should be addressed. e-mail: IJG3{at}columbia.edu
Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and their effects on plasma lipids and coronary heart disease are discussed. 2) LPL actions in the nervous system, liver, and heart: the discussion focuses on LPL and tissue lipid uptake.
3) LPL gene regulation: the LPL promoter and its regulatory elements are described.
Abbreviations: CAD, coronary artery disease; FA, fatty acid; LPL, lipoprotein lipase; TG, triglyceride
Supplementary key words triglycerides • chylomicronemia • atherosclerosis • lipoproteins • lipid metabolism • mutations • human • promoter • review
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