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Correspondence to:
Peter Tontonoz, at Howard Hughes Medical Institute, UCLA School of Medicine, Box 951662, Los Angeles, CA 90095-1662., ptontonoz{at}mednet.ucla.edu (E-mail)
The nuclear receptor PPAR
This review focuses on recent advances in PPAR
Supplementary key words:
peroxisome proliferator-activated receptors, adipocyte, adipose tissue, diabetes, obesity
Copyright © 2002 by Lipid Research, Inc.
Thematic Review
PPARadigms and PPARadoxes: expanding roles for PPAR
Robert Walczaka and
Peter Tontonoza
in the control of lipid metabolism
a Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095-1662
is a central regulator of adipose tissue development and an important modulator of gene expression in a number of specialized cell types including adipocytes, epithelial cells, and macrophages. PPAR signaling pathways impact both cellular and systemic lipid metabolism and have links to obesity, diabetes, and cardiovascular disease. The ability to activate this receptor with small molecule ligands has made PPAR an attractive target for intervention in human metabolic disease. As our understanding of PPAR biology has expanded, so has the therapeutic potential of PPAR ligands. Recent studies have provided insight into the paradoxical relationship between PPAR and metabolic disease and established new paradigms for the control of lipid metabolism. biology in the areas of adipocyte differentiation, insulin resistance, and atherosclerosis. — Walczak, R., and P. Tontonoz. PPARadigms and PPARadoxes: expanding roles for PPAR in the control of lipid metabolism. J. Lipid. Res. 2002. 43: 177–186. 
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