| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Thematic Review |
in the control of lipid metabolism
Correspondence to: Peter Tontonoz, at Howard Hughes Medical Institute, UCLA School of Medicine, Box 951662, Los Angeles, CA 90095-1662., ptontonoz{at}mednet.ucla.edu (E-mail)
The nuclear receptor PPAR is a central regulator of adipose tissue development and an important modulator of gene expression in a number of specialized cell types including adipocytes, epithelial cells, and macrophages. PPAR signaling pathways impact both cellular and systemic lipid metabolism and have links to obesity, diabetes, and cardiovascular disease. The ability to activate this receptor with small molecule ligands has made PPAR an attractive target for intervention in human metabolic disease. As our understanding of PPAR biology has expanded, so has the therapeutic potential of PPAR ligands. Recent studies have provided insight into the paradoxical relationship between PPAR and metabolic disease and established new paradigms for the control of lipid metabolism.
This review focuses on recent advances in PPAR biology in the areas of adipocyte differentiation, insulin resistance, and atherosclerosis. — Walczak, R., and P. Tontonoz. PPARadigms and PPARadoxes: expanding roles for PPAR in the control of lipid metabolism. J. Lipid. Res. 2002. 43: 177–186.
Supplementary key words: peroxisome proliferator-activated receptors, adipocyte, adipose tissue, diabetes, obesity
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Walter and F. Seebacher Molecular mechanisms underlying the development of endothermy in birds (Gallus gallus): a new role of PGC-1{alpha}? Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2007; 293(6): R2315 - R2322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kos, A. L. Harte, S. James, D. R. Snead, J. P. O'Hare, P. G. McTernan, and S. Kumar Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue mass Am J Physiol Endocrinol Metab, November 1, 2007; 293(5): E1335 - E1340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Izem and R. E. Morton Possible Role for Intracellular Cholesteryl Ester Transfer Protein in Adipocyte Lipid Metabolism and Storage J. Biol. Chem., July 27, 2007; 282(30): 21856 - 21865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Majuri, M Santaniemi, K Rautio, A Kunnari, J Vartiainen, A Ruokonen, Y A Kesaniemi, J S Tapanainen, O Ukkola, and L Morin-Papunen Rosiglitazone treatment increases plasma levels of adiponectin and decreases levels of resistin in overweight women with PCOS: a randomized placebo-controlled study Eur. J. Endocrinol., February 1, 2007; 156(2): 263 - 269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Degenhardt, M. Matilainen, K.-H. Herzig, T. W. Dunlop, and C. Carlberg The Insulin-like Growth Factor-binding Protein 1 Gene Is a Primary Target of Peroxisome Proliferator-activated Receptors J. Biol. Chem., December 22, 2006; 281(51): 39607 - 39619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Soriguer, S. Morcillo, F. Cardona, G. Rojo-Martinez, M. de la Cruz Almaraz, M. de la Soledad Ruiz de Adana, G. Olveira, F. Tinahones, and I. Esteva Pro12Ala Polymorphism of the PPARG2 Gene Is Associated with Type 2 Diabetes Mellitus and Peripheral Insulin Sensitivity in a Population with a High Intake of Oleic Acid J. Nutr., September 1, 2006; 136(9): 2325 - 2330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Abildayeva, P. J. Jansen, V. Hirsch-Reinshagen, V. W. Bloks, A. H. F. Bakker, F. C. S. Ramaekers, J. de Vente, A. K. Groen, C. L. Wellington,, F. Kuipers, et al. 24(S)-Hydroxycholesterol Participates in a Liver X Receptor-controlled Pathway in Astrocytes That Regulates Apolipoprotein E-mediated Cholesterol Efflux J. Biol. Chem., May 5, 2006; 281(18): 12799 - 12808. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. L. Gough and M. C. O'Donovan Clustering of metabolic comorbidity in schizophrenia: a genetic contribution? J Psychopharmacol, November 1, 2005; 19(6_suppl): 47 - 55. [Abstract] [PDF]
|
|
|
|
|
|
F. Molnar, M. Matilainen, and C. Carlberg Structural Determinants of the Agonist-independent Association of Human Peroxisome Proliferator-activated Receptors with Coactivators J. Biol. Chem., July 15, 2005; 280(28): 26543 - 26556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Vanttinen, P. Nuutila, J. Pihlajamaki, K. Hallsten, K. A. Virtanen, R. Lautamaki, P. Peltoniemi, J. Kemppainen, T. Takala, A. P. M. Viljanen, et al. The Effect of the Ala12 Allele of the Peroxisome Proliferator-Activated Receptor-{gamma}2 Gene on Skeletal Muscle Glucose Uptake Depends on Obesity: A Positron Emission Tomography Study J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 4249 - 4254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Betz, I. Shapiro, M. Fassnacht, S. Hahner, M. Reincke, F. Beuschlein, and for the German Austrian Adrenal Network Peroxisome Proliferator-Activated Receptor-{gamma} Agonists Suppress Adrenocortical Tumor Cell Proliferation and Induce Differentiation J. Clin. Endocrinol. Metab., July 1, 2005; 90(7): 3886 - 3896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Rousseaux, B. Lefebvre, L. Dubuquoy, P. Lefebvre, O. Romano, J. Auwerx, D. Metzger, W. Wahli, B. Desvergne, G. C. Naccari, et al. Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-{gamma} J. Exp. Med., April 18, 2005; 201(8): 1205 - 1215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu and S. R. Farmer Regulating the Balance between Peroxisome Proliferator-activated Receptor {gamma} and {beta}-Catenin Signaling during Adipogenesis: A GLYCOGEN SYNTHASE KINASE 3{beta} PHOSPHORYLATION-DEFECTIVE MUTANT OF {beta}-CATENIN INHIBITS EXPRESSION OF A SUBSET OF ADIPOGENIC GENES J. Biol. Chem., October 22, 2004; 279(43): 45020 - 45027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Benson, H. A. Pershadsingh, C. I. Ho, A. Chittiboyina, P. Desai, M. Pravenec, N. Qi, J. Wang, M. A. Avery, and T. W. Kurtz Identification of Telmisartan as a Unique Angiotensin II Receptor Antagonist With Selective PPAR{gamma}-Modulating Activity Hypertension, May 1, 2004; 43(5): 993 - 1002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Saez, J. Rosenfeld, A. Livolsi, P. Olson, E. Lombardo, M. Nelson, E. Banayo, R. D. Cardiff, J. C. Izpisua-Belmonte, and R. M. Evans PPAR{gamma} signaling exacerbates mammary gland tumor development Genes & Dev., March 1, 2004; 18(5): 528 - 540. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Carley, L. M. Semeniuk, Y. Shimoni, E. Aasum, T. S. Larsen, J. P. Berger, and D. L. Severson Treatment of type 2 diabetic db/db mice with a novel PPAR{gamma} agonist improves cardiac metabolism but not contractile function Am J Physiol Endocrinol Metab, March 1, 2004; 286(3): E449 - E455. [Abstract] [Full Text]
|
|
|
|
 |
|
 P. Ferre The Biology of Peroxisome Proliferator-Activated Receptors: Relationship With Lipid Metabolism and Insulin Sensitivity Diabetes, February 1, 2004; 53(90001): S43 - 50. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. A. Lyons, H. Wittenburg, R. Li, K. A. Walsh, G. A. Churchill, M. C. Carey, and B. Paigen Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice, J. Lipid Res., May 1, 2003; 44(5): 953 - 967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yu, K. Matsusue, P. Kashireddy, W.-Q. Cao, V. Yeldandi, A. V. Yeldandi, M. S. Rao, F. J. Gonzalez, and J. K. Reddy Adipocyte-specific Gene Expression and Adipogenic Steatosis in the Mouse Liver Due to Peroxisome Proliferator-activated Receptor gamma 1 (PPARgamma 1) Overexpression J. Biol. Chem., January 3, 2003; 278(1): 498 - 505. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Copland, P. J. Davies, G. L. Shipley, C. G. Wood, B. A. Luxon, and R. J. Urban The Use of DNA Microarrays to Assess Clinical Samples: The Transition from Bedside to Bench to Bedside Recent Prog. Horm. Res., January 1, 2003; 58(1): 25 - 53. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Journal of Biological Chemistry |
| Molecular and Cellular Proteomics | ASBMB Today |
