|
Advertisement | |||||||||||||||||||||||||
Journal of Lipid Research, Vol. 43, 762-767, May 2002 Significant utilization of dietary arachidonic acid is for brain adrenic acid in baboon neonates
* Division of Nutritional Sciences, Cornell University Savage Hall Ithaca, NY 14853
1 To whom correspondence should be addressed. e-mail: jtb4{at}cornell.edu
Dietary arachidonic acid (20:4n-6) utilization in-vivo for carbon recycling into de-novo lipogenesis and conversion to n-6 long chain polyunsaturates was investigated in baboon neonates using [U-13C]20:4n-6. Neonates consuming a formula typical of human milk received a single oral dose of [13C]arachidonic acid in sn-2 position of either triglyceride or phosphatidylcholine at 1819 days of postnatal life. Neonate brain, retina, liver, and plasma were obtained 10 days later (2829 days of life). Low isotopic enrichment (0.271.0%Total label) was detected in dihomo-
Abbreviations: CNS, central nervous system; FAME, fatty acid methyl ester; LCP, long chain PUFA; MUFA, monounsaturated fatty acids; PC-20:4*, phosphatidylcholine with 20:4* in the sn-2 position and palmitate in the sn-1 position; SFA, saturated fatty acids; TG-20:4*, triglyceride with 20:4* in the sn-2 position and palmitate in the sn-1, 3 positions; 20:4*, [13C]arachidonic acid Supplementary key words infant primate stable isotope tracer carbon recycling polyunsaturated fatty acids dihomo-gamma linolenic acid
|
| ||||||||||||||||||||||||
|
Advertisement | |||||||||||||||||||||||||