HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Schurgers, L. J. Articles by Vermeer, C. Search for Related Content PubMed PubMed Citation Articles by Schurgers, L. J. Articles by Vermeer, C. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 43, 878-884, June 2002
Copyright © 2002 by Lipid Research, Inc.

Novel effects of diets enriched with corn oil or with an olive oil/sunflower oil mixture on vitamin K metabolism and vitamin K-dependent proteins in young men

Leon J. Schurgers^*, Martin J. Shearer, Berry A. M. Soute^*, Ibrahim Elmadfa, Julia Harvey, Karl-Heinz Wagner, Richard Tomasch and Cees Vermeer^1,*

^* Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, The Netherlands
Institute of Nutritional Sciences, University of Vienna, Austria
Haemophilia Centre, Saint Thomas' Hospital, London, UK

¹ To whom correspondence should be addressed. e-mail: c.vermeer{at}bioch.unimaas.nl

Little is known of how the fat components of diets influence the absorption and metabolism of vitamin K and the possible consequences to the synthesis of vitamin K-dependent (VKD) proteins in different target organs. We have evaluated the effects of two diets on circulating phylloquinone (K₁) and triacylglycerols (TAG). One diet was enriched with corn oil (CO) (also rich in -tocopherol) and the other with an olive/sunflower (O/SO) mixture (rich in -tocopherol). Effects on -carboxylation were assessed from coagulation assays and sensitive assays for undercarboxylated prothrombin (ucFII) and osteocalcin (ucOC). Total plasma matrix Gla-protein (MGP) was also measured. After an initial adjustment diet, 26 healthy young men were fed, in a crossover design, the O/SO or CO diet for 2 weeks. Mean intakes of K₁ during consumption of adjustment, O/SO, and CO diets were 225 µg/day, 291 µg/day, and 291 µg/day, respectively. Mean fasting levels of TAG and K₁ were both significantly reduced by the CO diet, but not by the O/SO diet. Neither diet reduced FII activity but ucFII became detectable in nine subjects, eight of whom showed this abnormality with both diets. The CO diet induced a rise in ucOC (P < 0.05), which was negatively correlated to ucFII (r = -0.71, P < 0.03). The CO but not O/SO diet induced a decrease of total circulating MGP.

We conclude that both oils, notably CO, affected vitamin K absorption and/or metabolism which may increase the requirements for -carboxylation. The mechanism is unclear but may result from interactions of vitamin K with PUFA and/or other lipid components such as vitamin E.

Abbreviations: AU/l, arbitrary units per liter; CO, corn oil; K1, phylloquinone; MGP, matrix Gla-protein; O/SO, olive/sunflower oil; PT, prothrombin times; TAG, triacylglycerols; ucOC, undercarboxylated osteocalcin; ucFII, undercarboxylated prothrombin; VKD, vitamin K-dependent

Supplementary key words vitamin E • vegetable oils • gammacarboxy glutamate • blood coagulation • healthy volunteers

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?