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Journal of Lipid Research, Vol. 43, 1125-1132, July 2002
Copyright © 2002 by Lipid Research, Inc.

Methods

Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry

B. Kalderon, V. Sheena, S. Shachrur, R. Hertz and J. Bar-Tana¹

Department of Human Nutrition and Metabolism, Hebrew University Medical School, Jerusalem, Israel 91120

¹ To whom correspondence should be addressed. e-mail: bartanaj{at}cc.huji.ac.il

The profile of liver acyl-CoAs induced by dietary fats of variable compositions or by xenobiotic hypolipidemic amphipathic carboxylates was evaluated in vivo using a novel electrospray ionization tandem mass spectrometry methodology of high resolution, sensitivity, and reliability. The composition of liver fatty acyl-CoAs was found to reflect the composition of dietary fat. Treatment with hypolipidemic carboxylates resulted in liver dominant abundance of their respective acyl-CoAs accompanied by an increase in liver fatty acyl-CoAs.

Cellular effects exerted by dietary fatty acids and/or xenobiotic carboxylic drugs may be transduced in vivo by their respective acyl-CoAs.

Abbreviations: Medica 14, ß,ß'-tetramethyltetradecane-,-dioic acid; Medica 16, ß,ß'-tetramethylhexadecane-,-dioic acid; Medica 18, ß,ß'-tetramethyloctadecane-,-dioic acid

Supplementary key words fatty acids • hypolipidemic drugs • electrospray ionization tandem mass spectrometry • hepatocyte nuclear factor-4

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