HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kalderon, B. Articles by Bar-Tana, J. Search for Related Content PubMed PubMed Citation Articles by Kalderon, B. Articles by Bar-Tana, J. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 43, 1125-1132, July 2002
Copyright © 2002 by Lipid Research, Inc.

Methods

Modulation by nutrients and drugs of liver acyl-CoAs analyzed by mass spectrometry

B. Kalderon, V. Sheena, S. Shachrur, R. Hertz and J. Bar-Tana¹

Department of Human Nutrition and Metabolism, Hebrew University Medical School, Jerusalem, Israel 91120

¹ To whom correspondence should be addressed. e-mail: bartanaj{at}cc.huji.ac.il

The profile of liver acyl-CoAs induced by dietary fats of variable compositions or by xenobiotic hypolipidemic amphipathic carboxylates was evaluated in vivo using a novel electrospray ionization tandem mass spectrometry methodology of high resolution, sensitivity, and reliability. The composition of liver fatty acyl-CoAs was found to reflect the composition of dietary fat. Treatment with hypolipidemic carboxylates resulted in liver dominant abundance of their respective acyl-CoAs accompanied by an increase in liver fatty acyl-CoAs.

Cellular effects exerted by dietary fatty acids and/or xenobiotic carboxylic drugs may be transduced in vivo by their respective acyl-CoAs.

Abbreviations: Medica 14, ß,ß'-tetramethyltetradecane-,-dioic acid; Medica 16, ß,ß'-tetramethylhexadecane-,-dioic acid; Medica 18, ß,ß'-tetramethyloctadecane-,-dioic acid

Supplementary key words fatty acids • hypolipidemic drugs • electrospray ionization tandem mass spectrometry • hepatocyte nuclear factor-4

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				C. A. Haynes, J. C. Allegood, K. Sims, E. W. Wang, M. C. Sullards, and A. H. Merrill Jr. Quantitation of fatty acyl-coenzyme As in mammalian cells by liquid chromatography-electrospray ionization tandem mass spectrometry J. Lipid Res., May 1, 2008; 49(5): 1113 - 1125. [Abstract] [Full Text] [PDF]

				T. A. Bell III, M. D. Wilson, K. Kelley, J. K. Sawyer, and L. L. Rudel Monounsaturated fatty acyl-coenzyme A is predictive of atherosclerosis in human apoB-100 transgenic, LDLr-/- mice J. Lipid Res., May 1, 2007; 48(5): 1122 - 1131. [Abstract] [Full Text] [PDF]

				G. Las, N. Mayorek, K. Dickstein, and J. Bar-Tana Modulation of Insulin Secretion by Fatty Acyl Analogs Diabetes, December 1, 2006; 55(12): 3478 - 3485. [Abstract] [Full Text] [PDF]

				R. Hertz, B. Kalderon, T. Byk, I. Berman, G. Za'tara, R. Mayer, and J. Bar-Tana Thioesterase Activity and Acyl-CoA/Fatty Acid Cross-talk of Hepatocyte Nuclear Factor-4{alpha} J. Biol. Chem., July 1, 2005; 280(26): 24451 - 24461. [Abstract] [Full Text] [PDF]