HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Murdoch, S. J. Articles by Albers, J. J. Search for Related Content PubMed PubMed Citation Articles by Murdoch, S. J. Articles by Albers, J. J. Social Bookmarking                      What's this?

Journal of Lipid Research, Vol. 43, 1256-1263, August 2002
Copyright © 2002 by Lipid Research, Inc.

Selective and independent associations of phospholipid transfer protein and hepatic lipase with the LDL subfraction distribution

Susan J. Murdoch^*,, Molly C. Carr^*, Hal Kennedy^*,, John D. Brunzell^1,* and John J. Albers^*,

^* Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA
Northwest Lipid Research Laboratories, Department of Medicine,, University of Washington, Seattle, WA

¹ To whom correspondence should be addressed. e-mail: brunzell{at}u.washington.edu

Phospholipid transfer protein (PLTP), hepatic lipase (HL), and lipoprotein lipase (LPL) have all been reported to be intricately involved in HDL metabolism but the effect of PLTP on the apolipoprotein B-containing lipoproteins relative to that of HL and LPL has not been established. Due to our previous observation of a positive correlation of PLTP activity with plasma apoB and LDL cholesterol, the relationship of PLTP with the LDL subfractions was investigated and compared with that of HL and LPL. Plasma lipoproteins from 50 premenopausal women were fractionated by density gradient ultracentrifugation. Correlations were calculated between the cholesterol concentration of each fraction and plasma PLTP, HL, and LPL activity. Plasma PLTP activity was highly, positively, and selectively correlated with the cholesterol concentration of the buoyant LDL/dense IDL fractions, yet demonstrated a complete absence of an association with the dense LDL fractions. In contrast, HL was positively correlated with the dense LDL fractions but showed no association with buoyant LDL. LPL was also positively correlated with several buoyant LDL fractions; however, the correlations were weaker than those of PLTP. PLTP and LPL were positively correlated and HL was negatively correlated with HDL fractions.

The results suggest that PLTP and HL may be important and independent determinants of the LDL subpopulation density distributions.

Abbreviations: HL, hepatic lipase; PLTP, phospholipid transfer protein

Supplementary key words lipoprotein lipase • low density lipoprotein • lipoprotein distribution • high density lipoprotein • HDL

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. T. Janis, S. Siggins, E. Tahvanainen, R. Vikstedt, K. Silander, J. Metso, A. Aromaa, M.-R. Taskinen, V. M. Olkkonen, M. Jauhiainen, et al. Active and low-active forms of serum phospholipid transfer protein in a normal Finnish population sample J. Lipid Res., December 1, 2004; 45(12): 2303 - 2309. [Abstract] [Full Text] [PDF]

				S. J. Murdoch, S. E. Kahn, J. J. Albers, J. D. Brunzell, and J. Q. Purnell PLTP activity decreases with weight loss: changes in PLTP are associated with changes in subcutaneous fat and FFA but not IAF or insulin sensitivity J. Lipid Res., September 1, 2003; 44(9): 1705 - 1712. [Abstract] [Full Text] [PDF]