J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.M200319-JLR200 on November 4, 2002

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Journal of Lipid Research, Vol. 44, 193-197, January 2003
Copyright © 2003 by Lipid Research, Inc.

Efficiency of intestinal cholesterol absorption in humans is not related to apoE phenotype

Klaus von Bergmann1,*, Dieter Lütjohann*, Bernhard Lindenthal* and Armin Steinmetz{dagger}

* Department of Clinical Pharmacology, University of Bonn, Germany
{dagger} St. Nikolaus Stiftshospital, Andernach, Germany, Teaching Hospital University of Bonn

1 To whom all correspondence should be addressed. e-mail: vonbergmann{at}uni-bonn.de

The present study investigated the role of apolipoprotein E (apoE) phenotype on intestinal cholesterol absorption and cholesterol synthesis. Studies were carried out in eight subjects homozygous for the apoE4 and 12 subjects homozygous for the E2 allele (six normocholesterolemic volunteers and six patients with type III hyperlipoproteinemia). Cholesterol absorption did not differ between the three groups of subjects and averaged 38 ± 2% (mean ± SEM) in normolipemic E2/2, 37 ± 4% in type III hyperlipemic E2/2, and 41 ± 3% in E4/4 subjects, respectively. Dietary intake of fat and cholesterol had no influence on cholesterol absorption efficiency. A positive correlation between efficiency of cholesterol absorption and the ratio of campesterol to cholesterol in plasma, an indirect marker for cholesterol absorption, was observed after combining the results of the three groups (r = 0.504; P < 0.02). Bile acid and total cholesterol synthesis were also not affected by the different apoE alleles, but the well-known relationship between body weight and cholesterol synthesis was noticed (r = 0.574; P < 0.01).

Thus, the present study provides evidence that the efficiency of intestinal absorption and synthesis of cholesterol in humans are not related to the apoE phenotype.

Supplementary key words bile acid synthesis • cholesterol synthesis • apolipoprotein E • campesterol


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