J. Lipid Res.
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Originally published In Press as doi:10.1194/jlr.M300118-JLR200 on July 16, 2003

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Journal of Lipid Research, Vol. 44, 1902-1908, October 2003
Copyright © 2003 by American Society for Biochemistry and Molecular Biology

The T111I mutation in the EL gene modulates the impact of dietary fat on the HDL profile in women

Marie-Eve Paradis*, Patrick Couture{dagger}, Yohan Bossé{dagger},§, Jean-Pierre Després**, Louis Pérusse{dagger}{dagger}, Claude Bouchard§§, Marie-Claude Vohl*,{dagger},§ and Benoît Lamarche1,*

* Nutraceuticals and Functional Foods Institute, Pavillon Paul-Comtois, Office 2423, Laval University, Québec G1K 7P4, Canada
{dagger} Lipid Research Center, CHUL Research Center, Québec, Canada
§ Food Sciences and Nutrition Department, Laval University, Québec, Canada
** Laval Hospital Research Center, Laval University, Québec, Canada
{dagger}{dagger} Department of Social and Preventive Medicine, Division of Kinesiology, Laval University, Québec, Canada
§§ Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA

1 To whom correspondence should be addressed. e-mail: benoit.lamarche{at}inaf.ulaval.ca

The objective of the present study was to examine the impact of the T111I missense mutation in exon 3 of the endothelial lipase (EL) gene on HDL and its potential interaction effect with dietary fat. The study sample included 281 women and 216 men aged between 17 and 76 years from the Québec Family Study. Plasma HDL3-C levels of I111I homozygote women were higher compared with those of women carrying the wild-type allele (P = 0.03). These differences were not attenuated when adjusted for levels of obesity and were not observed among men. Dietary PUFA interacted with the T111I mutation to modulate apolipoprotein A-I (apoA-I) and HDL3-C levels among women. Specifically, a diet rich in PUFA was associated with increased apoA-I levels among women carriers of the I111 allele and with decreased apoA-I among women homozygotes for the wild-type allele (P = 0.002). A similar interaction was observed with plasma HDL3-C levels (P = 0.003). These interactions were not observed among men.

In conclusion, the EL T111I mutation appears to have a modest effect on plasma HDL levels. The gene-diet interaction among women, however, suggests that the T111I missense mutation may confer protection against the lowering effect of a high dietary PUFA intake on plasma apoA-I and HDL3-C levels.

Supplementary key words apolipoprotein A-I • lipase gene family • gene-diet interaction • high density lipoprotein • endothelial lipase


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