J. Lipid Res. Did you know there is a large type edition? Click here.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1194/jlr.M300172-JLR200 on July 16, 2003

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
M300172-JLR200v1
44/10/1946    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ko, C.
Right arrow Articles by Huang, L.-S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ko, C.
Right arrow Articles by Huang, L.-S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Journal of Lipid Research, Vol. 44, 1946-1955, October 2003
Copyright © 2003 by American Society for Biochemistry and Molecular Biology

A fish oil diet produces different degrees of suppression of apoB and triglyceride secretion in human apoB transgenic mouse strains

Carol Ko, Shawn M. O'Rourke and Li-Shin Huang1

Department of Medicine, Columbia University, College of Physicians & Surgeons, New York, NY 10032

1 To whom correspondence should be addressed. e-mail: lh99{at}columbia.edu

Human apolipoprotein B (apoB) transgenic (HuBTg) mouse strains were used to assess genetic effects on the response to fish oil (FO), a source of n-3 fatty acids. A congenic HuBTg strain of the C57BL/6 (B6) background and six F1 HuBTg strains were fed a FO for 2 weeks. Different responses of plasma lipid levels to FO were observed among these strains. In particular, plasma apoB levels changed minimally in FO-fed male B6 HuBTg mice, but increased markedly (~40%) in FO-fed male FVB/NJ (FVB) x B6 F1 HuBTg mice. These strain differences were determined mainly by hepatic apoB secretion rates and were likely regulated by posttranscriptional mechanisms. In addition, plasma triglyceride (TG) levels were reduced (14%) in FO-fed B6 mice, but not in FVB x B6 mice. These strain differences were determined mainly by TG secretion rates, but were not due to differences in hepatic lipogenesis. Hepatic mRNA levels of acyl-CoA oxidase, reflective of peroxisomal ß-oxidation rate, were increased in FO-fed B6 but not in FVB x B6 mice, which could account for the difference in TG secretion rates.

In summary, differential effects of FO on plasma apoB and TG levels in B6 and FVB x B6 HuBTg mice were associated with strain differences in hepatic apoB and TG secretion and in peroxisomal ß-oxidation.

Abbreviations: AOX, acyl-CoA oxidase; B6, C57BL/6; CPTI, carnitine palmitoyltransferase; FAS, fatty acid synthase; FVB, FVB/NJ; FO, fish oil; HuBTg, human apoB transgenic mouse; LDLR, LDL receptor; MTP, microsomal triglyceride transfer protein; PPAR, peroxisome proliferator-activated receptor; SREBP, sterol responsive element binding protein; TG, triglyceride; WTD, Western-type diet

Supplementary key words apolipoprotein B secretion • low density lipoprotein receptor • hepatic lipogenesis • peroxisomal ß-oxidation • acyl-CoA oxidase


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
B. N. Reid, G. P. Ables, O. A. Otlivanchik, G. Schoiswohl, R. Zechner, W. S. Blaner, I. J. Goldberg, R. F. Schwabe, S. C. Chua Jr., and L.-S. Huang
Hepatic Overexpression of Hormone-sensitive Lipase and Adipose Triglyceride Lipase Promotes Fatty Acid Oxidation, Stimulates Direct Release of Free Fatty Acids, and Ameliorates Steatosis
J. Biol. Chem., May 9, 2008; 283(19): 13087 - 13099.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-L. Zhang, A. Hernandez-Ono, P. Siri, S. Weisberg, D. Conlon, M. J. Graham, R. M. Crooke, L.-S. Huang, and H. N. Ginsberg
Aberrant Hepatic Expression of PPAR{gamma}2 Stimulates Hepatic Lipogenesis in a Mouse Model of Obesity, Insulin Resistance, Dyslipidemia, and Hepatic Steatosis
J. Biol. Chem., December 8, 2006; 281(49): 37603 - 37615.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. Li, L. N. Thorne, N. M. Punjabi, C.-K. Sun, A. R. Schwartz, P. L. Smith, R. L. Marino, A. Rodriguez, W. C. Hubbard, C. P. O'Donnell, et al.
Intermittent Hypoxia Induces Hyperlipidemia in Lean Mice
Circ. Res., September 30, 2005; 97(7): 698 - 706.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.