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Journal of Lipid Research, Vol. 44, 2019-2029, November 2003
Copyright © 2003 by American Society for Biochemistry and Molecular Biology

Thematic Review

Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease

Neelima B. Chauhan¹

Research and Development, Veterans Affairs Chicago Health Care System–West Side VA Medical Center, Chicago, IL 60612
Department of NeuroAnesthesiology, University of Illinois at Chicago, Chicago, IL 60612

¹ To whom correspondence should be addressed. e-mail: nchauhan{at}uic.edu

Alzheimer's disease (AD) is characterized by the deposition of ß-amyloid (Aß) plaques derived from the amyloidogenic processing; of a transmembrane protein called ß-amyloid precursor protein (APP). In addition to the known genetic/sporadic factors that promote the formation of Aß, the composition and structural dynamics of the membrane are also thought to play a significant role in the amyloidogenic processing of APP that promotes seeding of Aß.

This minireview reinforces the roles played by membrane dynamics, membrane microdomains, and cholesterol homeostasis in relation to amyloidogenesis, and reviews current strategies of lowering cholesterol in treating AD.

Supplementary key words ß-amyloid precursor • protein processing • lipid raft • caveolae • glycophosphatidylinositol • apolipoprotein E

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