J. Lipid Res. Neurobiology of Lipids (ISSN1683-5506)
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1194/jlr.M300124-JLR200 on August 16, 2003

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
M300124-JLR200v1
44/11/2059    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moreno, J. A.
Right arrow Articles by Pérez-Jiménez, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moreno, J. A.
Right arrow Articles by Pérez-Jiménez, F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Lipid Research, Vol. 44, 2059-2064, November 2003
Copyright © 2003 by American Society for Biochemistry and Molecular Biology

The influence of the apolipoprotein E gene promoter (-219G/ T) polymorphism on postprandial lipoprotein metabolism in young normolipemic males

Juan Antonio Moreno*, José López-Miranda*, Carmen Marín*, Purificación Gómez*, Pablo Pérez-Martínez*, Francisco Fuentes*, Rafael Angel Fernández de la Puebla*, Juan Antonio Paniagua*, José María Ordovas{dagger} and Francisco Pérez-Jiménez1,*

* Lipids and Atherosclerosis Research Unit, Hospital Reina Sofía University, Córdoba, Spain
{dagger} Jean Mayer-United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111-1524

1 To whom correspondence should be addressed. e-mail: fperezjimenez{at}uco.es

The apolipoprotein E (apoE) gene promoter (-219G/T) polymorphism has been associated with increased risk of myocardial infarction, premature coronary heart disease, and decreased plasma apoE concentrations. We examined whether the -219G/T polymorphism could modify the postprandial response of triacylglycerol-rich lipoproteins (TRLs). Fifty-one healthy apoE 3/3 male volunteers (14GG, 29GT, and 8TT) were given a vitamin A fat-loading test consisting of 1 g of fat/kg body weight and 60,000 IU of vitamin A per m2 of body surface area. Blood samples were taken at time 0 and every hour until the sixth hour, and every 2 hours and 30 minutes until the eleventh hour. Cholesterol, triacylglycerols (TGs), and apoE were determined in plasma; and cholesterol, TG, apoB-100, apoB-48, and retinyl palmitate (RP) were analyzed in lipoprotein fractions. Postprandial lipemia data revealed that subjects with the -219TT genotype had a higher postprandial response of large TRL-cholesterol (P < 0.03), large TRL-triacylglycerols (P < 0.001), large TRL-RP (P < 0.004), and small TRL-apoB-48 (P < 0.03) than carriers of the -219G allele. Moreover, the -219TT subjects had the lowest postprandial levels of serum apoE (P < 0.05).

In conclusion, the -219G/T polymorphism may influence TRL metabolism during the postprandial period, thus prolonging postprandial lipemia in subjects with the TT genotype.

Supplementary key words postprandial lipemia • triacylglycerols • retinyl palmitate • cholesterol • triacylglycerol-rich lipoproteins


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Nutr.Home page
J. Delgado-Lista, F. Perez-Jimenez, T. Tanaka, P. Perez-Martinez, Y. Jimenez-Gomez, C. Marin, J. Ruano, L. Parnell, J. M. Ordovas, and J. Lopez-Miranda
An Apolipoprotein A-II Polymorphism (-265T/C, rs5082) Regulates Postprandial Response to a Saturated Fat Overload in Healthy Men
J. Nutr., September 1, 2007; 137(9): 2024 - 2028.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. Moreno-Luna, F. Perez-Jimenez, C. Marin, P. Perez-Martinez, P. Gomez, Y. Jimenez-Gomez, J. Delgado-Lista, J. A. Moreno, T. Tanaka, J. M. Ordovas, et al.
Two Independent Apolipoprotein A5 Haplotypes Modulate Postprandial Lipoprotein Metabolism in a Healthy Caucasian Population
J. Clin. Endocrinol. Metab., June 1, 2007; 92(6): 2280 - 2285.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
K. E. North, H. H. H. Goring, S. A. Cole, V. P. Diego, L. Almasy, S. Laston, T. Cantu, B. V. Howard, E. T. Lee, L. G. Best, et al.
Linkage analysis of LDL cholesterol in American Indian populations: the Strong Heart Family Study
J. Lipid Res., January 1, 2006; 47(1): 59 - 66.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
J. A. Moreno, F. Perez-Jimenez, C. Marin, P. Perez-Martinez, R. Moreno, P. Gomez, Y. Jimenez-Gomez, J. A. Paniagua, D. Lairon, and J. Lopez-Miranda
The Apolipoprotein E Gene Promoter (-219G/T) Polymorphism Determines Insulin Sensitivity in Response to Dietary Fat in Healthy Young Adults
J. Nutr., November 1, 2005; 135(11): 2535 - 2540.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
J. A. Moreno, F. Perez-Jimenez, C. Marin, P. Gomez, P. Perez-Martinez, R. Moreno, C. Bellido, F. Fuentes, and J. Lopez-Miranda
Apolipoprotein E gene promoter -219G->T polymorphism increases LDL-cholesterol concentrations and susceptibility to oxidation in response to a diet rich in saturated fat
Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1404 - 1409.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.