| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Journal of Lipid Research, Vol. 44, 296-302, February 2003
Copyright © 2003 by Lipid Research, Inc.
* Molecular Disease Branch, NHLBI, National Institutes of Health, Bethesda, MD 20862
Institut Pasteur, Department d'Atherosclerose, Lille, France
Aventis Pharma, Vitry sur Seine, France
1 To whom correspondence should be addressed. e-mail: fbasso{at}mail.nih.gov
The current model for reverse cholesterol transport proposes that HDL transports excess cholesterol derived primarily from peripheral cells to the liver for removal. However, recent studies in ABCA1 transgenic mice suggest that the liver itself may be a major source of HDL cholesterol (HDL-C). To directly investigate the hepatic contribution to plasma HDL-C levels, we generated an adenovirus (rABCA1-GFP-AdV) that targets expression of mouse ABCA1-GFP in vivo to the liver. Compared with mice injected with control AdV, infusion of rABCA1-GFP-AdV into C57Bl/6 mice resulted in increased expression of mouse ABCA1 mRNA and protein in the liver. ApoA-I-dependent cholesterol efflux was increased 2.6-fold in primary hepatocytes isolated 1 day after rABCA1-GFP-AdV infusion. Hepatic ABCA1 expression in C57Bl/6 mice (n = 15) raised baseline levels of TC, PL, FC, HDL-C, apoE, and apoA-I by 150–300% (P < 0.05 all). ABCA1 expression led to significant compensatory changes in expression of genes that increase hepatic cholesterol, including HMG-CoA reductase (3.5-fold), LDLr (2.1-fold), and LRP (5-fold) in the liver.
These combined results demonstrate that ABCA1 plays a key role in hepatic cholesterol efflux, inducing pathways that modulate cholesterol homeostasis in the liver, and establish the liver as a major source of plasma HDL-C.
Supplementary key words reverse cholesterol transport • lipoprotein • cholesterol • Tangier disease
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Gao, Y. Xu, Y. Yang, Y. Yang, Z. Zheng, W. Jiang, B. Hong, X. Yan, and S. Si Identification of Upregulators of Human ATP-Binding Cassette Transporter A1 via High-Throughput Screening of a Synthetic and Natural Compound Library J Biomol Screen, August 1, 2008; 13(7): 648 - 656. [Abstract] [PDF]
|
|
|
|
 |
|
 I. Tancevski, A. Wehinger, E. Demetz, P. Eller, K. Duwensee, J. Huber, K. Hochegger, W. Schgoer, C. Fievet, F. Stellaard, et al. Reduced Plasma High-Density Lipoprotein Cholesterol in Hyperthyroid Mice Coincides with Decreased Hepatic Adenosine 5'-Triphosphate-Binding Cassette Transporter 1 Expression Endocrinology, July 1, 2008; 149(7): 3708 - 3712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. H. Hassan, D. Bailey, D.-Y. D. Lee, I. Iatan, A. Hafiane, I. Ruel, L. Krimbou, and J. Genest Quantitative Analysis of ABCA1-dependent Compartmentalization and Trafficking of Apolipoprotein A-I: IMPLICATIONS FOR DETERMINING CELLULAR KINETICS OF NASCENT HIGH DENSITY LIPOPROTEIN BIOGENESIS J. Biol. Chem., April 25, 2008; 283(17): 11164 - 11175. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Bates, J.-Q. Tao, K. J. Yu, Z. Borok, E. D. Crandall, H. L. Collins, and G. H. Rothblat Expression and Biological Activity of ABCA1 in Alveolar Epithelial Cells Am. J. Respir. Cell Mol. Biol., March 1, 2008; 38(3): 283 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Mulya, J.-Y. Lee, A. K. Gebre, M. J. Thomas, P. L. Colvin, and J. S. Parks Minimal Lipidation of Pre-{beta} HDL by ABCA1 Results in Reduced Ability to Interact with ABCA1 Arterioscler. Thromb. Vasc. Biol., August 1, 2007; 27(8): 1828 - 1836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Tamehiro, Y. Shigemoto-Mogami, T. Kakeya, K.-i. Okuhira, K. Suzuki, R. Sato, T. Nagao, and T. Nishimaki-Mogami Sterol Regulatory Element-binding Protein-2- and Liver X Receptor-driven Dual Promoter Regulation of Hepatic ABC Transporter A1 Gene Expression: MECHANISM UNDERLYING THE UNIQUE RESPONSE TO CELLULAR CHOLESTEROL STATUS J. Biol. Chem., July 20, 2007; 282(29): 21090 - 21099. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kyriakou, D. E. Pontefract, E. Viturro, C. P. Hodgkinson, R. C. Laxton, N. Bogari, G. Cooper, M. Davies, J. Giblett, I. N.M. Day, et al. Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients Hum. Mol. Genet., June 15, 2007; 16(12): 1412 - 1422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wang and J. F. Oram Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C {delta} pathway J. Lipid Res., May 1, 2007; 48(5): 1062 - 1068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Basso, L. A. Freeman, C. Ko, C. Joyce, M. J. Amar, R. D. Shamburek, T. Tansey, F. Thomas, J. Wu, B. Paigen, et al. Hepatic ABCG5/G8 overexpression reduces apoB-lipoproteins and atherosclerosis when cholesterol absorption is inhibited J. Lipid Res., January 1, 2007; 48(1): 114 - 126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Post, M. Groenendijk, C. C. van der Hoogt, C. Fievet, G. Luc, M. Hoekstra, H. M.G. Princen, B. Staels, and P. C.N. Rensen Cholesterol 7{alpha}-Hydroxylase Deficiency in Mice on an APOE*3-Leiden Background Increases Hepatic ABCA1 mRNA Expression and HDL-Cholesterol Arterioscler. Thromb. Vasc. Biol., December 1, 2006; 26(12): 2724 - 2730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Joyce, E. M. Wagner, F. Basso, M. J. Amar, L. A. Freeman, R. D. Shamburek, C. L. Knapper, J. Syed, J. Wu, B. L. Vaisman, et al. ABCA1 Overexpression in the Liver of LDLr-KO Mice Leads to Accumulation of Pro-atherogenic Lipoproteins and Enhanced Atherosclerosis J. Biol. Chem., November 3, 2006; 281(44): 33053 - 33065. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Quinet, D. A. Savio, A. R. Halpern, L. Chen, G. U. Schuster, J.-A. Gustafsson, M. D. Basso, and P. Nambi Liver X Receptor (LXR)-beta Regulation in LXR{alpha}-Deficient Mice: Implications for Therapeutic Targeting Mol. Pharmacol., October 1, 2006; 70(4): 1340 - 1349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Aravindhan, C. L. Webb, M. Jaye, A. Ghosh, R. N. Willette, N. J. DiNardo, and B. M. Jucker Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study J. Lipid Res., June 1, 2006; 47(6): 1250 - 1260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. T. Duong, H. L. Collins, M. Nickel, S. Lund-Katz, G. H. Rothblat, and M. C. Phillips Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I J. Lipid Res., April 1, 2006; 47(4): 832 - 843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Van Eck, R. R. Singaraja, D. Ye, R. B. Hildebrand, E. R. James, M. R. Hayden, and T. J.C. Van Berkel Macrophage ATP-Binding Cassette Transporter A1 Overexpression Inhibits Atherosclerotic Lesion Progression in Low-Density Lipoprotein Receptor Knockout Mice Arterioscler. Thromb. Vasc. Biol., April 1, 2006; 26(4): 929 - 934. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, C. Einarsson, C. Murphy, P. Parini, I. Bjorkhem, M. Gafvels, and G. Eggertsen Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice J. Lipid Res., February 1, 2006; 47(2): 421 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Wu and D. E. Cohen Phosphatidylcholine transfer protein regulates size and hepatic uptake of high-density lipoproteins Am J Physiol Gastrointest Liver Physiol, December 1, 2005; 289(6): G1067 - G1074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K.-i. Okuhira, M. L. Fitzgerald, D. A. Sarracino, J. J. Manning, S. A. Bell, J. L. Goss, and M. W. Freeman Purification of ATP-binding Cassette Transporter A1 and Associated Binding Proteins Reveals the Importance of {beta}1-Syntrophin in Cholesterol Efflux J. Biol. Chem., November 25, 2005; 280(47): 39653 - 39664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang and J. F. Oram Unsaturated Fatty Acids Phosphorylate and Destabilize ABCA1 through a Phospholipase D2 Pathway J. Biol. Chem., October 28, 2005; 280(43): 35896 - 35903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-Y. Lee, J. M. Timmins, A. Mulya, T. L. Smith, Y. Zhu, E. M. Rubin, J. W. Chisholm, P. L. Colvin, and J. S. Parks HDLs in apoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are hypercatabolized by the kidney J. Lipid Res., October 1, 2005; 46(10): 2233 - 2245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Singaraja, E. R. James, J. Crim, H. Visscher, A. Chatterjee, and M. R. Hayden Alternate transcripts expressed in response to diet reflect tissue-specific regulation of ABCA1 J. Lipid Res., October 1, 2005; 46(10): 2061 - 2071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. Tovar, I. Torre-Villalvazo, M. Ochoa, A. L. Elias, V. Ortiz, C. A. Aguilar-Salinas, and N. Torres Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats J. Lipid Res., September 1, 2005; 46(9): 1823 - 1832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Wu and D. E. Cohen Altered hepatic cholesterol metabolism compensates for disruption of phosphatidylcholine transfer protein in mice Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G456 - G461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Krimbou, H. Hajj Hassan, S. Blain, S. Rashid, M. Denis, M. Marcil, and J. Genest Biogenesis and speciation of nascent apoA-I-containing particles in various cell lines J. Lipid Res., August 1, 2005; 46(8): 1668 - 1677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hajj Hassan, S. Blain, B. Boucher, M. Denis, L. Krimbou, and J. Genest Structural modification of plasma HDL by phospholipids promotes efficient ABCA1-mediated cholesterol release J. Lipid Res., July 1, 2005; 46(7): 1457 - 1465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ragozin, A. Niemeier, A. Laatsch, B. Loeffler, M. Merkel, U. Beisiegel, and J. Heeren Knockdown of Hepatic ABCA1 by RNA Interference Decreases Plasma HDL Cholesterol Levels and Influences Postprandial Lipemia in Mice Arterioscler. Thromb. Vasc. Biol., July 1, 2005; 25(7): 1433 - 1438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. F. Lewis and D. J. Rader New Insights Into the Regulation of HDL Metabolism and Reverse Cholesterol Transport Circ. Res., June 24, 2005; 96(12): 1221 - 1232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zheng, R. S. Kiss, V. Franklin, M.-D. Wang, B. Haidar, and Y. L. Marcel ApoA-I Lipidation in Primary Mouse Hepatocytes: SEPARATE CONTROLS FOR PHOSPHOLIPID AND CHOLESTEROL TRANSFERS J. Biol. Chem., June 3, 2005; 280(22): 21612 - 21621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Coutinho, R. R. Singaraja, M. Kang, D. J. Arenillas, L. N. Bertram, N. Bissada, B. Staels, J.-C. Fruchart, C. Fievet, A. M. Joseph-George, et al. Complete functional rescue of the ABCA1-/- mouse by human BAC transgenesis J. Lipid Res., June 1, 2005; 46(6): 1113 - 1123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Fasano, L. Bocchi, L. Pisciotta, S. Bertolini, and S. Calandra Denaturing high-performance liquid chromatography in the detection of ABCA1 gene mutations in familial HDL deficiency J. Lipid Res., April 1, 2005; 46(4): 817 - 822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. van der Veen, J. K. Kruit, R. Havinga, J. F. W. Baller, G. Chimini, S. Lestavel, B. Staels, P. H. E. Groot, A. K. Groen, and F. Kuipers Reduced cholesterol absorption upon PPAR{delta} activation coincides with decreased intestinal expression of NPC1L1 J. Lipid Res., March 1, 2005; 46(3): 526 - 534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Wong, C. M. Quinn, and A. J. Brown Statins Inhibit Synthesis of an Oxysterol Ligand for the Liver X Receptor in Human Macrophages With Consequences for Cholesterol Flux Arterioscler. Thromb. Vasc. Biol., December 1, 2004; 24(12): 2365 - 2371. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Fitzgerald, K.-i. Okuhira, G. F. Short III, J. J. Manning, S. A. Bell, and M. W. Freeman ATP-binding Cassette Transporter A1 Contains a Novel C-terminal VFVNFA Motif That Is Required for Its Cholesterol Efflux and ApoA-I Binding Activities J. Biol. Chem., November 12, 2004; 279(46): 48477 - 48485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Jacobs, C. Devlin, I. Tabas, and D. E. Vance Targeted Deletion of Hepatic CTP:phosphocholine Cytidylyltransferase {alpha} in Mice Decreases Plasma High Density and Very Low Density Lipoproteins J. Biol. Chem., November 5, 2004; 279(45): 47402 - 47410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Inoue, J. Inoue, G. Lambert, S. H. Yim, and F. J. Gonzalez Disruption of Hepatic C/EBP{alpha} Results in Impaired Glucose Tolerance and Age-dependent Hepatosteatosis J. Biol. Chem., October 22, 2004; 279(43): 44740 - 44748. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ando, S. Tsuruoka, H. Yamamoto, T. Takamura, S. Kaneko, and A. Fujimura Effects of Pravastatin on the Expression of ATP-Binding Cassette Transporter A1 J. Pharmacol. Exp. Ther., October 1, 2004; 311(1): 420 - 425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Denis, B. Haidar, M. Marcil, M. Bouvier, L. Krimbou, and J. Genest Characterization of Oligomeric Human ATP Binding Cassette Transporter A1: POTENTIAL IMPLICATIONS FOR DETERMINING THE STRUCTURE OF NASCENT HIGH DENSITY LIPOPROTEIN PARTICLES J. Biol. Chem., October 1, 2004; 279(40): 41529 - 41536. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. B. Brewer Jr, A. T. Remaley, E. B. Neufeld, F. Basso, and C. Joyce Regulation of Plasma High-Density Lipoprotein Levels by the ABCA1 Transporter and the Emerging Role of High-Density Lipoprotein in the Treatment of Cardiovascular Disease Arterioscler. Thromb. Vasc. Biol., October 1, 2004; 24(10): 1755 - 1760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sahoo, T. C. Trischuk, T. Chan, V. A. B. Drover, S. Ho, G. Chimini, L. B. Agellon, R. Agnihotri, G. A. Francis, and R. Lehner ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes J. Lipid Res., June 1, 2004; 45(6): 1122 - 1131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Selva, V. Hirsch-Reinshagen, B. Burgess, S. Zhou, J. Chan, S. McIsaac, M. R. Hayden, G. L. Hammond, A. W. Vogl, and C. L. Wellington The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility J. Lipid Res., June 1, 2004; 45(6): 1040 - 1050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Wu, F. Basso, R. D. Shamburek, M. J. A. Amar, B. Vaisman, G. Szakacs, C. Joyce, T. Tansey, L. Freeman, B. J. Paigen, et al. Hepatic ABCG5 and ABCG8 Overexpression Increases Hepatobiliary Sterol Transport but Does Not Alter Aortic Atherosclerosis in Transgenic Mice J. Biol. Chem., May 28, 2004; 279(22): 22913 - 22925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Akiyama, G. Lambert, C. J. Nicol, K. Matsusue, J. M. Peters, H. B. Brewer Jr., and F. J. Gonzalez Peroxisome Proliferator-activated Receptor {beta}/{delta} Regulates Very Low Density Lipoprotein Production and Catabolism in Mice on a Western Diet J. Biol. Chem., May 14, 2004; 279(20): 20874 - 20881. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Fu, A. Hoang, G. Escher, R. G. Parton, Z. Krozowski, and D. Sviridov Expression of Caveolin-1 Enhances Cholesterol Efflux in Hepatic Cells J. Biol. Chem., April 2, 2004; 279(14): 14140 - 14146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Lyons, H. Wittenburg, R. Li, K. A. Walsh, R. Korstanje, G. A. Churchill, M. C. Carey, and B. Paigen Quantitative trait loci that determine lipoprotein cholesterol levels in an intercross of 129S1/SvImJ and CAST/Ei inbred mice Physiol Genomics, March 12, 2004; 17(1): 60 - 68. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. B. Brewer Jr. High-Density Lipoproteins: A New Potential Therapeutic Target for the Prevention of Cardiovascular Disease Arterioscler. Thromb. Vasc. Biol., March 1, 2004; 24(3): 387 - 391. [Full Text]
|
|
|
|
 |
|
 H. Hattori, T. Kujiraoka, T. Egashira, E. Saito, T. Fujioka, S. Takahashi, M. Ito, J. A. Cooper, I. P. Stepanova, M. N. Nanjee, et al. Association of Coronary Heart Disease with Pre-{beta}-HDL Concentrations in Japanese Men Clin. Chem., March 1, 2004; 50(3): 589 - 595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Denis, B. Haidar, M. Marcil, M. Bouvier, L. Krimbou, and J. Genest Jr. Molecular and Cellular Physiology of Apolipoprotein A-I Lipidation by the ATP-binding Cassette Transporter A1 (ABCA1) J. Biol. Chem., February 27, 2004; 279(9): 7384 - 7394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Kovacs, J. E. Shackelford, K. N. Tape, M. J. Richards, P. L. Faust, S. J. Fliesler, and S. K. Krisans Disturbed Cholesterol Homeostasis in a Peroxisome-Deficient PEX2 Knockout Mouse Model Mol. Cell. Biol., January 1, 2004; 24(1): 1 - 13. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-C. Jiang, T. P. Beyer, Z. Li, J. Liu, W. Quan, R. J. Schmidt, Y. Zhang, W. R. Bensch, P. I. Eacho, and G. Cao Enlargement of High Density Lipoprotein in Mice via Liver X Receptor Activation Requires Apolipoprotein E and Is Abolished by Cholesteryl Ester Transfer Protein Expression J. Biol. Chem., December 5, 2003; 278(49): 49072 - 49078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Chisholm, J. Hong, S. A. Mills, and R. M. Lawn The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse J. Lipid Res., November 1, 2003; 44(11): 2039 - 2048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Macdonald, T. L. Terry, L. B. Agellon, P. N. Nation, and G. A. Francis Administration of Tyrosyl Radical-Oxidized HDL Inhibits the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice Arterioscler. Thromb. Vasc. Biol., September 1, 2003; 23(9): 1583 - 1588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Wellington, L. R. Brunham, S. Zhou, R. R. Singaraja, H. Visscher, A. Gelfer, C. Ross, E. James, G. Liu, M. T. Huber, et al. Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1 J. Lipid Res., August 1, 2003; 44(8): 1470 - 1480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Wang and A. R. Tall Regulation and Mechanisms of ATP-Binding Cassette Transporter A1-Mediated Cellular Cholesterol Efflux Arterioscler. Thromb. Vasc. Biol., July 1, 2003; 23(7): 1178 - 1184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Joyce, L. Freeman, H. B. Brewer Jr, and S. Santamarina-Fojo Study of ABCA1 Function in Transgenic Mice Arterioscler. Thromb. Vasc. Biol., June 1, 2003; 23(6): 965 - 971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Kiss, D. C. McManus, V. Franklin, W. L. Tan, A. McKenzie, G. Chimini, and Y. L. Marcel The Lipidation by Hepatocytes of Human Apolipoprotein A-I Occurs by Both ABCA1-dependent and -independent Pathways J. Biol. Chem., March 14, 2003; 278(12): 10119 - 10127. [Abstract] |
