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Journal of Lipid Research, Vol. 44, 762-769, April 2003
Copyright © 2003 by Lipid Research, Inc.

Dietary fat modulation of apoA-II metabolism and prevention of senile amyloidosis in the senescence- accelerated mouse

Makiko Umezawa^1,*, Kenjiro Tatematsu, Tatsumi Korenaga^**, Xiaoying Fu^**, Takatoshi Matushita, Harumi Okuyama, Masanori Hosokawa, Toshio Takeda and Keiichi Higuchi^**

^* Department of Nutrition, Koshien University, 10-1 Momijigaoka, Takarazuka, Hyogo 665-0006, Japan
Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Biological Chemistry, Nagoya City University, Nagoya 467-8603, Japan
Field of Regeneration Control, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8397, Japan
^** Department of Aging Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto 390-8621, Japan

¹ To whom correspondence should be addressed. e-mail: umezawa{at}koshien.ac.jp

Senescence-accelerated mouse-prone (SAMP1; SAMP1@Umz) is an animal model of senile amyloidosis with apolipoprotein A-II (apoA-II) amyloid fibril (AApoAII) deposits. This study was undertaken to investigate the effects of dietary fats on AApoAII deposits in SAMP1 mice when purified diets containing 4% fat as butter, safflower oil, or fish oil were fed to male mice for 26 weeks. The serum HDL cholesterol was significantly lower (P < 0.01) in mice on the diet containing fish oil (7.4 ± 3.0 mg/dl) than in mice on the butter diet (38.7 ± 12.5 mg/dl), which in turn had significantly lower (P < 0.01) HDL levels than mice on the safflower oil diet (51.9 ± 5.6 mg/dl). ApoA-II was also significantly lower (P < 0.01) in mice on the fish oil diet (7.6 ± 2.7 mg/dl) than on the butter (26.9 ± 7.3 mg/dl) or safflower oil (21.6 ± 3.7 mg/dl) diets. The mice fed fish oil had a significantly greater ratio (P < 0.01) of apoA-I to apoA-II, and a smaller HDL particle size than those fed butter and safflower oil. Severe AApoAII deposits in the spleen, heart, skin, liver, and stomach were shown in the fish oil group compared with those in the butter and safflower oil groups (fish oil > butter > safflower oil group, P < 0.05).

These findings suggest that dietary fats differ in their effects on serum lipoprotein metabolism, and that dietary lipids may modulate amyloid deposition in SAMP1 mice.

Abbreviations: AApoAII, apolipoprotein A-II amyloid fibrils; SAM, senescence-accelerated mouse

Supplementary key words apolipoprotein A-II • apolipoprotein A-II amyloid fibril • high density lipoprotein

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