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Journal of Lipid Research, Vol. 44, 1423-1430, August 2003
Copyright © 2003 by American Society for Biochemistry and Molecular Biology

Thematic Review

Cholesterol

Robert L. Raffaï^* and Karl H. Weisgraber^1,*,

^* Department of Pathology, Gladstone Institutes of Cardiovascular Disease and Neurological Disease, University of California, San Francisco, CA 94141-9100
Cardiovascular Research Institute, Gladstone Institutes of Cardiovascular Disease and Neurological Disease, University of California, San Francisco, CA 94141-9100

¹ To whom correspondence should be addressed. e-mail: kweisgraber{at}gladstone.ucsf.edu

The accumulation and aggregation of the amyloid-ß peptide (Aß) in the brain are important contributing factors to Alzheimer's disease (AD). Consequently, blocking the generation of Aß is a potentially important treatment strategy. Recent work on the metabolism of Aß has identified several cellular proteins and proteases that collectively promote or prevent the generation of Aß.

In addition, accumulating in vitro and in vivo evidence suggests a role for cholesterol in modulating the cellular processing of Aß with the potential to affect AD.

Supplementary key words Alzheimer's disease • amyloid precursor protein • amyloid-ß peptide • 24S-cholesterol hydroxylase • 24-hydroxycholesterol • apolipoprotein E

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