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Originally published In Press as doi:10.1194/jlr.M300214-JLR200 on October 16, 2003

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Journal of Lipid Research, Vol. 45, 124-131, January 2004
Copyright © 2004 by American Society for Biochemistry and Molecular Biology

Fasting acylation-stimulating protein is predictive of postprandial triglyceride clearance

Katherine Cianflone1,*, Robert Zakarian*, Charles Couillard{dagger}, Bernadette Delplanque§, Jean-Pierre Despres{dagger} and Allan Sniderman*

* Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue, West Montreal, Quebec H3A 1A1, Canada
{dagger} Lipid Research Centre, Centre Hospitalier Universitaire de Québec Research Centre and Department of Food Sciences and Nutrition, Laval University, Sainte-Foy, Canada
§ Laboratoire de Physiologie et de la Nutrition, Universite Paris Sud, Orsay, France

1 To whom correspondence should be addressed. e-mail: katherine.cianflone{at}mcgill.ca

Postprandial plasma triglyceride (ppTG) and NEFA clearance were stratified by plasma acylation-stimulating protein (ASP) and gender to determine the contribution of fasting ASP in a normal population (70 men; 71 women). In the highest ASP tertile only, ASP decreased over 8 h (90 ± 9.7 nM to 70 ± 5.9 nM, P < 0.05 males; 61.9 ± 4.0 nM to 45.6 ± 6.2 nM, P < 0.01 females). Fasting ASP correlated positively with ppTG response. ppTG (P < 0.0001, 2-way ANOVA, both genders) and NEFA levels progressively increased from lowest to highest ASP tertile, with the greatest differences in males. By stepwise multiple regression, the best prediction of ppTG was: (fasting ASP + apolipoprotein B + insulin + TG; r = 0.806) for men and (fasting ASP + total cholesterol; r = 0.574) for women. Leptin, body mass index, and other fasting variables did not improve the prediction. Thus, in men and women, ASP significantly predicted ppTG and NEFA clearance and, based on lower ASP, women may be more ASP sensitive than men.

Plasma ASP may be useful as a fasting variable that will provide additional information regarding ppTG and NEFA clearance.

Abbreviations: ASP, acylation-stimulating protein; BMI, body mass index; HOMA, homeostatic model of insulin resistance; iAUC, incremental area under the curve; RM-ANOVA, repeated measures analyses of variance; TG, triglyceride

Supplementary key words C3adesArg • fatty acid • insulin • leptin


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