J. Lipid Res.  Neurobiology of Lipids (ISSN1683-5506)
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


Originally published In Press as doi:10.1194/jlr.R400008-JLR200 on September 17, 2004 Originally published In Press as doi:10.1194/jlr.R400008-JLR200 on September 16, 2004

Papers In Press, published online ahead of print December 1, 2004
J. Lipid Res., doi:10.1194/jlr.R400008-JLR200
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
R400008-JLR200v1
R400008-JLR200v2
45/12/2174    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bossé, Y.
Right arrow Articles by Vohl, M.-C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bossé, Y.
Right arrow Articles by Vohl, M.-C.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Journal of Lipid Research, Vol. 45, 2174-2184, December 2004
Copyright © 2004 by American Society for Biochemistry and Molecular Biology


Review

Compendium of genome-wide scans of lipid-related phenotypes

: adding a new genome-wide search of apolipoprotein levels

Yohan Bossé*,{dagger}, Yvon C. Chagnon§, Jean-Pierre Després*,{dagger},**, Treva Rice{dagger}{dagger}, D. C. Rao{dagger}{dagger}, Claude Bouchard§§, Louis Pérusse*** and Marie-Claude Vohl1,*,{dagger}

* Lipid Research Center, Laval University Medical Research Center, Québec, Canada
{dagger} Department of Food Sciences and Nutrition, Laval University
§ Laval University Robert-Giffard Research Center, Beauport
** The Québec Heart Institute, Québec, Canada
{dagger}{dagger} Division of Biostatistics, Washington University School of Medicine, St. Louis, MO
§§ Pennington Biomedical Research Center, Baton Rouge, LA
*** Division of Kinesiology, Department of Social and Preventive Medicine, Laval University, Québec, Canada

1 To whom correspondence should be addressed. e-mail: marie-claude.vohl{at}crchul.ulaval.ca

The genetic dissection of complex inherited diseases is a major challenge. Despite limited success in finding genes, substantial data based on genome-wide scan strategies is now available for a variety of diseases and related phenotypes. This can perhaps best be appreciated in the field of lipid and lipoprotein levels, where the amount of information generated is becoming overwhelming. We have created a database containing the results from whole-genome scans of lipid-related phenotypes undertaken to date. The usefulness of this database is demonstrated by performing a new autosomal genomic scan on apolipoprotein B (apoB), LDL-apoB, and apoA-I levels, measured in 679 subjects of 243 nuclear families. Linkage was tested using both allele-sharing and variance-component methods. Only two loci provided support for linkage with both methods: a LDL-apoB locus on 18q21.32 and an apoA-I locus on 3p25.2.

Adding those findings to the database highlighted the fact that the former is reported as a lipid-related locus for the first time, whereas the latter has been observed before. However, concerns arise when displaying all data on the same map, because a large portion of the genome is now covered with loci supported by at least suggestive evidence of linkage.

Abbreviations: apoB, apolipoprotein B; CHD, coronary heart disease; cM, centimorgan; IBD, identical by descent; LOD, logarithm of the odds; QFS, Québec Family Study; QTL, quantitative trait locus

Supplementary key words lipoproteins • quantitative trait locus • cardiovascular risk factors • linkage • dyslipidemia


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
J. Lipid Res.Home page
B. Kaess, M. Fischer, A. Baessler, K. Stark, F. Huber, W. Kremer, H. R. Kalbitzer, H. Schunkert, G. Riegger, and C. Hengstenberg
The lipoprotein subfraction profile: heritability and identification of quantitative trait loci
J. Lipid Res., April 1, 2008; 49(4): 715 - 723.
[Abstract] [Full Text] [PDF]


Home page
J. Lipid Res.Home page
R. Sherva, P. Yue, G. Schonfeld, and R. J. Neuman
Evidence for a quantitative trait locus affecting low levels of apolipoprotein B and low density lipoprotein on chromosome 10 in Caucasian families
J. Lipid Res., December 1, 2007; 48(12): 2632 - 2639.
[Abstract] [Full Text] [PDF]


Home page
J. Lipid Res.Home page
K. E. North, H. H. H. Goring, S. A. Cole, V. P. Diego, L. Almasy, S. Laston, T. Cantu, B. V. Howard, E. T. Lee, L. G. Best, et al.
Linkage analysis of LDL cholesterol in American Indian populations: the Strong Heart Family Study
J. Lipid Res., January 1, 2006; 47(1): 59 - 66.
[Abstract] [Full Text] [PDF]


Home page
Hum Mol GenetHome page
A. Malhotra, H. Coon, M. F. Feitosa, W.-D. Li, K. E. North, R. A. Price, C. Bouchard, S. C. Hunt, J. K. Wolford, and The American Diabetes Association GENNID Study Gro
Meta-analysis of genome-wide linkage studies for quantitative lipid traits in African Americans
Hum. Mol. Genet., December 15, 2005; 14(24): 3955 - 3962.
[Abstract] [Full Text] [PDF]


Home page
Hum Mol GenetHome page
M. Falchi, T. Andrew, H. Snieder, R. Swaminathan, G. L. Surdulescu, and T. D. Spector
Identification of QTLs for serum lipid levels in a female sib-pair cohort: a novel application to improve the power of two-locus linkage analysis
Hum. Mol. Genet., October 15, 2005; 14(20): 2971 - 2979.
[Abstract] [Full Text] [PDF]


Home page
DiabetesHome page
A. Malhotra, J. K. Wolford, and the American Diabetes Association GENNID Study Gro
Analysis of Quantitative Lipid Traits in the Genetics of NIDDM (GENNID) Study
Diabetes, October 1, 2005; 54(10): 3007 - 3014.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Journal of Biological Chemistry 
 Molecular and Cellular Proteomics   ASBMB Today 
Copyright © 2004 by the American Society for Biochemistry and Molecular Biology.