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Papers In Press, published online ahead of print December 1, 2004
J. Lipid Res., doi:10.1194/jlr.R400008-JLR200

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Journal of Lipid Research, Vol. 45, 2174-2184, December 2004
Copyright © 2004 by American Society for Biochemistry and Molecular Biology

Review

Compendium of genome-wide scans of lipid-related phenotypes

: adding a new genome-wide search of apolipoprotein levels

Yohan Bossé^*,, Yvon C. Chagnon, Jean-Pierre Després^*,,**, Treva Rice, D. C. Rao, Claude Bouchard, Louis Pérusse^*** and Marie-Claude Vohl^1,*,

^* Lipid Research Center, Laval University Medical Research Center, Québec, Canada
Department of Food Sciences and Nutrition, Laval University
Laval University Robert-Giffard Research Center, Beauport
^** The Québec Heart Institute, Québec, Canada
Division of Biostatistics, Washington University School of Medicine, St. Louis, MO
Pennington Biomedical Research Center, Baton Rouge, LA
^*** Division of Kinesiology, Department of Social and Preventive Medicine, Laval University, Québec, Canada

¹ To whom correspondence should be addressed. e-mail: marie-claude.vohl{at}crchul.ulaval.ca

The genetic dissection of complex inherited diseases is a major challenge. Despite limited success in finding genes, substantial data based on genome-wide scan strategies is now available for a variety of diseases and related phenotypes. This can perhaps best be appreciated in the field of lipid and lipoprotein levels, where the amount of information generated is becoming overwhelming. We have created a database containing the results from whole-genome scans of lipid-related phenotypes undertaken to date. The usefulness of this database is demonstrated by performing a new autosomal genomic scan on apolipoprotein B (apoB), LDL-apoB, and apoA-I levels, measured in 679 subjects of 243 nuclear families. Linkage was tested using both allele-sharing and variance-component methods. Only two loci provided support for linkage with both methods: a LDL-apoB locus on 18q21.32 and an apoA-I locus on 3p25.2.

Adding those findings to the database highlighted the fact that the former is reported as a lipid-related locus for the first time, whereas the latter has been observed before. However, concerns arise when displaying all data on the same map, because a large portion of the genome is now covered with loci supported by at least suggestive evidence of linkage.

Abbreviations: apoB, apolipoprotein B; CHD, coronary heart disease; cM, centimorgan; IBD, identical by descent; LOD, logarithm of the odds; QFS, Québec Family Study; QTL, quantitative trait locus

Supplementary key words lipoproteins • quantitative trait locus • cardiovascular risk factors • linkage • dyslipidemia

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